AutismKB 2.0

Annotation Detail for MAP3K8


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Basic Information Top
Gene Symbol:MAP3K8 ( COT,EST,ESTF,FLJ10486,MEKK8,TPL2,Tpl-2,c-COT )
Gene Full Name: mitogen-activated protein kinase kinase kinase 8
Band: 10p11.23
Quick LinksEntrez ID:1326; OMIM: 191195; Uniprot ID:M3K8_HUMAN; ENSEMBL ID: ENSG00000107968; HGNC ID: 6860
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus16 / 56401228
neonate10 / 31097321
infant0 / 236200 
juvenile0 / 555560 
adult50 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor0 / 2638450 
glioma4 / 10688337
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal150 / 336030744
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood15 / 123478121
bone1 / 7165513
bone marrow0 / 488010 
brain24 / 110098921
cervix1 / 4817120
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus1 / 2020949
eye0 / 2110540 
heart4 / 8962644
intestine4 / 23447217
kidney5 / 21177723
larynx0 / 241450 
liver10 / 20774348
lung11 / 33697432
lymph0 / 442700 
lymph node3 / 9161032
mammary gland8 / 15327152
mouth2 / 6705229
muscle0 / 1077150 
nerve1 / 1576863
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta18 / 28082564
prostate3 / 18934515
salivary gland0 / 201550 
skin43 / 210574204
spleen2 / 5395237
stomach3 / 9661931
testis2 / 3304426
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord4 / 13680292
uterus8 / 23287834
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205027_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts18.05
Adipocyte12.9
AdrenalCortex26.3
Adrenalgland13.3
Amygdala10.6
Appendix25.35
AtrioventricularNode25.6
BDCA4+_DentriticCells21.55
Bonemarrow19
BronchialEpithelialCells12.2
CD105+_Endothelial12.75
CD14+_Monocytes16.2
CD19+_BCells(neg._sel.)51.9
CD33+_Myeloid23.9
CD34+15.3
CD4+_Tcells12.5
CD56+_NKCells99.55
CD71+_EarlyErythroid13.4
CD8+_Tcells12.7
CardiacMyocytes37.3
Caudatenucleus11.3
Cerebellum10.45
CerebellumPeduncles19.75
CiliaryGanglion21.25
CingulateCortex15.25
Colorectaladenocarcinoma12.5
DorsalRootGanglion13.4
FetalThyroid16.65
Fetalbrain12.45
Fetalliver11.45
Fetallung9.5
GlobusPallidus13.35
Heart23.95
Hypothalamus12.45
Kidney14.15
Leukemia_chronicMyelogenousK-56211
Leukemia_promyelocytic-HL-6013.75
Leukemialymphoblastic(MOLT-4)9.05
Liver27.7
Lung13.85
Lymphnode11
Lymphoma_burkitts(Daudi)18.6
Lymphoma_burkitts(Raji)47.85
MedullaOblongata10.6
OccipitalLobe11.5
OlfactoryBulb9.85
Ovary14.2
Pancreas13.1
PancreaticIslet15.5
ParietalLobe17.15
Pituitary15.9
Placenta19.3
Pons14.6
PrefrontalCortex13.35
Prostate13.45
Salivarygland12.4
SkeletalMuscle34.55
Skin20.35
SmoothMuscle15.55
Spinalcord13.3
SubthalamicNucleus13.4
SuperiorCervicalGanglion36.25
TemporalLobe13.65
Testis10.5
TestisGermCell9.75
TestisIntersitial13.9
TestisLeydigCell16.6
TestisSeminiferousTubule11.55
Thalamus14.35
Thymus9.35
Thyroid14.5
Tongue23.65
Tonsil14.2
Trachea10.85
TrigeminalGanglion31.1
Uterus10.7
UterusCorpus19.8
WholeBlood23.7
Wholebrain8.65
colon13.25
pineal_day25.76
pineal_night15.72
retina16.5
small_intestine12.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12305_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.9 ± 0.97
Basal Forebrain2.54 ± 0.5
Basal Part of Pons2.5 ± 0.59
Cerebellar Cortex2.12 ± 0.59
Cerebellar Nuclei3.08 ± 0.54
Claustrum3.19 ± 1.01
Epithalamus3.36 ± 0.48
Frontal Lobe2.43 ± 0.85
Globus Pallidus3.55 ± 0.77
Hypothalamus3.02 ± 1.57
Insula2.31 ± 0.45
Limbic Lobe2.49 ± 0.81
Mesencephalon2.6 ± 0.68
Myelencephalon2.58 ± 0.75
Occipital Lobe2.84 ± 0.92
Parietal Lobe2.74 ± 0.72
Pontine Tegmentum2.59 ± 0.83
Striatum2.92 ± 0.86
Subthalamus2.65 ± 0.55
Temporal Lobe2.44 ± 0.75
Thalamus2.46 ± 0.72
White Matter2.54 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Map3k8CBCerebellum11.32
11.8
Map3k8CTXCerebral cortex15.08
11.12
Map3k8HIPHippocampal region11.3
11.33
Map3k8HPFHippocampal formation8.11
7.46
Map3k8HYHypothalamus8.52
7.79
Map3k8LSXLateral septal complex5.75
4.13
Map3k8MBMidbrain6.25
6.34
Map3k8MYMedulla12.18
12.6
Map3k8OLFOlfactory bulb6.77
4.74
Map3k8PPons8.12
9.3
Map3k8PALPallidum10.33
9.99
Map3k8RHPRetrohippocampal region2.59
1.92
Map3k8sAMYStriatum-like amygdalar nuclei2.57
3.24
Map3k8STRStriatum12.85
9.82
Map3k8STRdStriatum dorsal region13.35
10.13
Map3k8STRvStriatum ventral region21.05
15.25
Map3k8THThalamus14.9
13.45
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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