AutismKB 2.0

Annotation Detail for COX5B


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Basic Information Top
Gene Symbol:COX5B ( COXVB )
Gene Full Name: cytochrome c oxidase subunit Vb
Band: 2q11.2
Quick LinksEntrez ID:1329; OMIM: 123866; Uniprot ID:COX5B_HUMAN; ENSEMBL ID: ENSG00000135940; HGNC ID: 2269
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus40 / 56401270
neonate3 / 3109796
infant0 / 236200 
juvenile1 / 5555617
adult165 / 193912185
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor1 / 3436629
chondrosarcoma5 / 8282360
colorectal tumor16 / 114246140
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor9 / 26384534
glioma7 / 10688365
head and neck tumor4 / 13630229
kidney tumor4 / 6895958
leukemia5 / 9584252
liver tumor9 / 9635993
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal196 / 336030758
ovarian tumor7 / 7668291
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer8 / 10268077
retinoblastoma0 / 463560 
skin tumor13 / 124949104
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland2 / 3319760
ascites2 / 4001549
bladder0 / 297570 
blood5 / 12347840
bone5 / 7165569
bone marrow2 / 4880140
brain46 / 110098941
cervix1 / 4817120
connective tissue4 / 14925526
ear2 / 16212123
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye15 / 21105471
heart14 / 89626156
intestine47 / 234472200
kidney14 / 21177766
larynx0 / 241450 
liver69 / 207743332
lung9 / 33697426
lymph0 / 442700 
lymph node2 / 9161021
mammary gland6 / 15327139
mouth0 / 670520 
muscle32 / 107715297
nerve0 / 157680 
ovary11 / 102051107
pancreas24 / 214812111
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland3 / 16585180
placenta9 / 28082532
prostate14 / 18934573
salivary gland1 / 2015549
skin13 / 21057461
spleen1 / 5395218
stomach4 / 9661941
testis4 / 33044212
thymus0 / 811310 
thyroid4 / 4747384
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord3 / 13680219
uterus4 / 23287817
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211025_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts1396.85
Adipocyte535.95
AdrenalCortex422.95
Adrenalgland607.2
Amygdala1233.8
Appendix185.95
AtrioventricularNode126.5
BDCA4+_DentriticCells913.9
Bonemarrow347.35
BronchialEpithelialCells991.55
CD105+_Endothelial1078.05
CD14+_Monocytes1134.2
CD19+_BCells(neg._sel.)891.15
CD33+_Myeloid1038.65
CD34+1349.1
CD4+_Tcells478.05
CD56+_NKCells954.55
CD71+_EarlyErythroid727.2
CD8+_Tcells441.55
CardiacMyocytes510.7
Caudatenucleus733.45
Cerebellum486.95
CerebellumPeduncles980.6
CiliaryGanglion137.2
CingulateCortex967.7
Colorectaladenocarcinoma756.6
DorsalRootGanglion164.65
FetalThyroid834
Fetalbrain320.35
Fetalliver318.4
Fetallung411.25
GlobusPallidus493.7
Heart8071.3
Hypothalamus1251.1
Kidney977.4
Leukemia_chronicMyelogenousK-562803.5
Leukemia_promyelocytic-HL-60767.75
Leukemialymphoblastic(MOLT-4)528.5
Liver2570.65
Lung1857.55
Lymphnode334.9
Lymphoma_burkitts(Daudi)722.1
Lymphoma_burkitts(Raji)1495.7
MedullaOblongata861.5
OccipitalLobe700.1
OlfactoryBulb404.1
Ovary255.8
Pancreas443.6
PancreaticIslet470.65
ParietalLobe808.3
Pituitary473.25
Placenta388.6
Pons582.75
PrefrontalCortex1441.7
Prostate2137.55
Salivarygland394.55
SkeletalMuscle1315.8
Skin227.75
SmoothMuscle666.35
Spinalcord700.15
SubthalamicNucleus808.4
SuperiorCervicalGanglion128.65
TemporalLobe1213.35
Testis503.1
TestisGermCell512.15
TestisIntersitial324.7
TestisLeydigCell272.6
TestisSeminiferousTubule301.45
Thalamus1380.35
Thymus547.2
Thyroid1793.45
Tongue789.8
Tonsil344.65
Trachea233.3
TrigeminalGanglion66.6
Uterus563.65
UterusCorpus211.35
WholeBlood774
Wholebrain3538.7
colon1370.7
pineal_day1113.56
pineal_night1082.14
retina933.45
small_intestine1027.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P51069
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala13.61 ± 0.19
Basal Forebrain13.5 ± 0.29
Basal Part of Pons13.85 ± 0.15
Cerebellar Cortex13.25 ± 0.21
Cerebellar Nuclei14.13 ± 0.15
Claustrum13.41 ± 0.4
Epithalamus13.44 ± 0.23
Frontal Lobe13.72 ± 0.36
Globus Pallidus13.9 ± 0.46
Hypothalamus13.72 ± 0.14
Insula13.59 ± 0.34
Limbic Lobe13.33 ± 0.51
Mesencephalon13.57 ± 0.45
Myelencephalon13.55 ± 0.38
Occipital Lobe13.23 ± 0.35
Parietal Lobe13.68 ± 0.39
Pontine Tegmentum13.65 ± 0.32
Striatum13.74 ± 0.35
Subthalamus14.23 ± 0.03
Temporal Lobe13.63 ± 0.37
Thalamus13.65 ± 0.26
White Matter13.04 ± 0.16
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
COX5B_HUMAN_0 0 0 0 KGLDPYNVLAPK PRIDE
COX5B_HUMAN_116 14 116 129 CGAHYKLVPQQLAH PRIDE
COX5B_HUMAN_122 8 122 129 LVPQQLAH PRIDE
COX5B_HUMAN_32 18 32 49 ASGGGVPTDEEQATGLER PRIDE
COX5B_HUMAN_50 7 50 56 EIMLAAK PRIDE
COX5B_HUMAN_56 12 56 67 KGLDPYNVLAPK PRIDE
COX5B_HUMAN_57 11 57 67 GLDPYNVLAPK PRIDE
COX5B_HUMAN_57 12 57 68 KGLDPYNVLAPK PRIDE
COX5B_HUMAN_58 11 58 68 GLDPYNVLAPK PRIDE
COX5B_HUMAN_58 17 58 74 GLDPYNVLAPKGASGTR PRIDE
COX5B_HUMAN_68 18 68 85 GASGTREDPNLVPSISNK PRIDE
COX5B_HUMAN_69 18 69 86 GASGTREDPNLVPSISNK PRIDE
COX5B_HUMAN_69 6 69 74 GASGTR PRIDE
COX5B_HUMAN_75 12 75 86 EDPNLVPSISNK PRIDE
COX5B_HUMAN_75 13 75 87 EDPNLVPSISNKR PRIDE
COX5B_HUMAN_77 11 77 87 PNLVPSISNKR PRIDE
PAp00004307 12 57 68 KGLDPYNVLAPK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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