AutismKB 2.0

Annotation Detail for NHEDC2


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Basic Information Top
Gene Symbol:NHEDC2 ( FLJ23984,NHA2,NHE10 )
Gene Full Name: Na+/H+ exchanger domain containing 2
Band: 4q24
Quick LinksEntrez ID:133308; OMIM: 611789; Uniprot ID:NHDC2_HUMAN; ENSEMBL ID: ENSG00000164038; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus31 / 56401254
neonate7 / 31097225
infant1 / 2362042
juvenile2 / 5555635
adult39 / 193912120
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor7 / 26384526
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor5 / 6895972
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal135 / 336030740
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood10 / 12347880
bone0 / 716550 
bone marrow0 / 488010 
brain75 / 110098968
cervix0 / 481710 
connective tissue10 / 14925566
ear1 / 1621261
embryonic tissue1 / 2157224
esophagus1 / 2020949
eye7 / 21105433
heart2 / 8962622
intestine1 / 2344724
kidney6 / 21177728
larynx0 / 241450 
liver4 / 20774319
lung5 / 33697414
lymph0 / 442700 
lymph node1 / 9161010
mammary gland2 / 15327113
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta6 / 28082521
prostate1 / 1893455
salivary gland0 / 201550 
skin2 / 2105749
spleen2 / 5395237
stomach1 / 9661910
testis8 / 33044224
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular4 / 5178077
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P81094
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.95 ± 0.4
Basal Forebrain4.93 ± 0.37
Basal Part of Pons5.55 ± 0.17
Cerebellar Cortex5.35 ± 0.31
Cerebellar Nuclei4.92 ± 0.38
Claustrum5.18 ± 0.75
Epithalamus5.3 ± 0.36
Frontal Lobe5.1 ± 0.4
Globus Pallidus4.01 ± 0.52
Hypothalamus5.17 ± 0.78
Insula5.19 ± 0.29
Limbic Lobe5.01 ± 0.51
Mesencephalon5.21 ± 0.57
Myelencephalon5.01 ± 0.58
Occipital Lobe5.06 ± 0.62
Parietal Lobe5.1 ± 0.52
Pontine Tegmentum4.97 ± 0.53
Striatum4.4 ± 0.51
Subthalamus4.71 ± 0.41
Temporal Lobe5.16 ± 0.42
Thalamus5.1 ± 0.52
White Matter4.25 ± 0.39
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
C80638CBCerebellum0.52
1.06
C80638CTXCerebral cortex0.12
0.13
C80638HIPHippocampal region0.05
0.05
C80638HPFHippocampal formation0.07
0.16
C80638HYHypothalamus0.06
0.15
C80638LSXLateral septal complex0.15
0.1
C80638MBMidbrain0.88
1.2
C80638MYMedulla0.5
0.46
C80638OLFOlfactory bulb0.08
0.08
C80638PPons0.18
0.28
C80638PALPallidum0.03
0.02
C80638RHPRetrohippocampal region0.1
0.34
C80638sAMYStriatum-like amygdalar nuclei0.02
0
C80638STRStriatum0.04
0.04
C80638STRdStriatum dorsal region0.03
0.02
C80638STRvStriatum ventral region0.04
0.06
C80638THThalamus0.06
0.07
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018