AutismKB 2.0

Annotation Detail for ADORA2A


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Basic Information Top
Gene Symbol:ADORA2A ( ADORA2,RDC8,hA2aR )
Gene Full Name: adenosine A2a receptor
Band: 22q11.23
Quick LinksEntrez ID:135; OMIM: 102776; Uniprot ID:AA2AR_HUMAN; ENSEMBL ID: ENSG00000100014,ENSG00000128271; HGNC ID: 263
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus13 / 56401223
neonate1 / 3109732
infant0 / 236200 
juvenile4 / 5555671
adult19 / 19391219
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor5 / 26384518
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia6 / 9584262
liver tumor2 / 9635920
lung tumor2 / 10312719
lymphoma3 / 7175541
non-neoplasia3 / 9725030
normal91 / 336030727
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood9 / 12347872
bone0 / 716550 
bone marrow0 / 488010 
brain34 / 110098930
cervix1 / 4817120
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye1 / 2110544
heart2 / 8962622
intestine5 / 23447221
kidney2 / 2117779
larynx0 / 241450 
liver4 / 20774319
lung12 / 33697435
lymph3 / 4427067
lymph node6 / 9161065
mammary gland1 / 1532716
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary2 / 10205119
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen9 / 53952166
stomach2 / 9661920
testis1 / 3304423
thymus26 / 81131320
thyroid0 / 474730 
tonsil3 / 16999176
trachea2 / 5241338
umbilical cord0 / 136800 
uterus1 / 2328784
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205013_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts19.8
Adipocyte3.55
AdrenalCortex3.9
Adrenalgland3
Amygdala3.8
Appendix3.5
AtrioventricularNode2.8
BDCA4+_DentriticCells5.45
Bonemarrow3.6
BronchialEpithelialCells3.55
CD105+_Endothelial3.65
CD14+_Monocytes3.95
CD19+_BCells(neg._sel.)47.85
CD33+_Myeloid8.55
CD34+4.65
CD4+_Tcells20.25
CD56+_NKCells5.35
CD71+_EarlyErythroid3.3
CD8+_Tcells32.5
CardiacMyocytes4.6
Caudatenucleus127.95
Cerebellum2.9
CerebellumPeduncles4.1
CiliaryGanglion2.6
CingulateCortex3.65
Colorectaladenocarcinoma3.6
DorsalRootGanglion2.7
FetalThyroid3.55
Fetalbrain3.6
Fetalliver3.05
Fetallung7.75
GlobusPallidus2.6
Heart4.6
Hypothalamus3.9
Kidney2.9
Leukemia_chronicMyelogenousK-5623.25
Leukemia_promyelocytic-HL-6020.5
Leukemialymphoblastic(MOLT-4)2.9
Liver4.7
Lung14.35
Lymphnode3.85
Lymphoma_burkitts(Daudi)20.2
Lymphoma_burkitts(Raji)49.55
MedullaOblongata11.55
OccipitalLobe3.2
OlfactoryBulb2.85
Ovary2.4
Pancreas2.9
PancreaticIslet3.8
ParietalLobe3.75
Pituitary4.2
Placenta3.5
Pons9.85
PrefrontalCortex4.55
Prostate6.4
Salivarygland2.9
SkeletalMuscle4.25
Skin2.75
SmoothMuscle4.15
Spinalcord3.8
SubthalamicNucleus3.2
SuperiorCervicalGanglion3.95
TemporalLobe3.3
Testis3.1
TestisGermCell3
TestisIntersitial3
TestisLeydigCell3.55
TestisSeminiferousTubule3.1
Thalamus3.65
Thymus140.5
Thyroid4.55
Tongue3.5
Tonsil3.65
Trachea3
TrigeminalGanglion3.6
Uterus2.95
UterusCorpus3.2
WholeBlood13.15
Wholebrain3.05
colon3.6
pineal_day4.46
pineal_night4.34
retina4.4
small_intestine3.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P109436
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.86 ± 0.74
Basal Forebrain5.92 ± 1.28
Basal Part of Pons4.84 ± 0.49
Cerebellar Cortex4.67 ± 0.19
Cerebellar Nuclei5.25 ± 0.86
Claustrum4.59 ± 0.7
Epithalamus4.29 ± 0.65
Frontal Lobe5.06 ± 0.62
Globus Pallidus5.54 ± 0.68
Hypothalamus4.32 ± 1.11
Insula5.01 ± 0.39
Limbic Lobe5.27 ± 0.72
Mesencephalon5.12 ± 0.85
Myelencephalon5.27 ± 1.04
Occipital Lobe5.64 ± 0.9
Parietal Lobe5.11 ± 0.68
Pontine Tegmentum5.28 ± 0.83
Striatum8.4 ± 1.09
Subthalamus5.25 ± 0.52
Temporal Lobe4.87 ± 0.42
Thalamus5.34 ± 0.59
White Matter4.37 ± 0.54
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Adora2aCBCerebellum0.56
0.63
Adora2aCTXCerebral cortex2.42
1.98
Adora2aHIPHippocampal region0.54
0.67
Adora2aHPFHippocampal formation0.53
0.62
Adora2aHYHypothalamus0.08
0.03
Adora2aLSXLateral septal complex3.4
2.96
Adora2aMBMidbrain0.28
0.35
Adora2aMYMedulla0.39
0.43
Adora2aOLFOlfactory bulb1.12
1.6
Adora2aPPons0.42
0.42
Adora2aPALPallidum4.1
3.39
Adora2aRHPRetrohippocampal region0.45
0.53
Adora2asAMYStriatum-like amygdalar nuclei4.11
2.4
Adora2aSTRStriatum79.18
60.21
Adora2aSTRdStriatum dorsal region99.58
77.28
Adora2aSTRvStriatum ventral region68.99
49.15
Adora2aTHThalamus0.34
0.58
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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