AutismKB 2.0

Annotation Detail for CPA3


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Basic Information Top
Gene Symbol:CPA3 ( MC-CPA )
Gene Full Name: carboxypeptidase A3 (mast cell)
Band: 3q24
Quick LinksEntrez ID:1359; OMIM: 114851; Uniprot ID:CBPA3_HUMAN; ENSEMBL ID: ENSG00000163751; HGNC ID: 2298
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus6 / 56401210
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult9 / 19391214
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor2 / 6895929
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal29 / 33603078
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow5 / 48801102
brain1 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine5 / 23447221
kidney3 / 21177714
larynx0 / 241450 
liver0 / 2077430 
lung8 / 33697423
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate4 / 18934521
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach3 / 9661931
testis2 / 3304426
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205624_at
Cell line Expression level Expression bar
721_B_lymphoblasts3.85
Adipocyte3.05
AdrenalCortex3.15
Adrenalgland2.55
Amygdala3.25
Appendix4.35
AtrioventricularNode2.3
BDCA4+_DentriticCells3.4
Bonemarrow3
BronchialEpithelialCells3
CD105+_Endothelial3.1
CD14+_Monocytes3.25
CD19+_BCells(neg._sel.)3.3
CD33+_Myeloid4.1
CD34+360.35
CD4+_Tcells3.35
CD56+_NKCells3.7
CD71+_EarlyErythroid2.85
CD8+_Tcells3
CardiacMyocytes3.8
Caudatenucleus2.75
Cerebellum2.45
CerebellumPeduncles3.45
CiliaryGanglion2.15
CingulateCortex3.1
Colorectaladenocarcinoma3.05
DorsalRootGanglion2.35
FetalThyroid2.95
Fetalbrain3.05
Fetalliver2.65
Fetallung2.55
GlobusPallidus2.25
Heart3.85
Hypothalamus3.35
Kidney2.45
Leukemia_chronicMyelogenousK-5622.75
Leukemia_promyelocytic-HL-602.7
Leukemialymphoblastic(MOLT-4)2.45
Liver4.05
Lung3.45
Lymphnode3.5
Lymphoma_burkitts(Daudi)3.9
Lymphoma_burkitts(Raji)4.25
MedullaOblongata2.8
OccipitalLobe2.75
OlfactoryBulb2.4
Ovary2.05
Pancreas2.45
PancreaticIslet3.25
ParietalLobe3.25
Pituitary3.6
Placenta3.15
Pons2.9
PrefrontalCortex3.9
Prostate3.6
Salivarygland2.45
SkeletalMuscle3.5
Skin3.1
SmoothMuscle3.45
Spinalcord3.25
SubthalamicNucleus2.8
SuperiorCervicalGanglion4.25
TemporalLobe2.8
Testis2.65
TestisGermCell2.6
TestisIntersitial2.6
TestisLeydigCell3
TestisSeminiferousTubule2.6
Thalamus3.1
Thymus2.45
Thyroid3.9
Tongue2.95
Tonsil2.95
Trachea2.55
TrigeminalGanglion3.15
Uterus6.05
UterusCorpus3.4
WholeBlood3.4
Wholebrain2.65
colon3.05
pineal_day3.86
pineal_night3.78
retina3.725
small_intestine3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10547_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.33 ± 0.95
Basal Forebrain1.95 ± 0.21
Basal Part of Pons1.66 ± 0.48
Cerebellar Cortex1.78 ± 0.67
Cerebellar Nuclei2.24 ± 0.69
Claustrum2.82 ± 0.84
Epithalamus1.65 ± 0.77
Frontal Lobe1.77 ± 0.67
Globus Pallidus2.68 ± 0.44
Hypothalamus1.94 ± 0.6
Insula1.9 ± 0.61
Limbic Lobe1.96 ± 0.62
Mesencephalon2.18 ± 0.67
Myelencephalon1.95 ± 0.65
Occipital Lobe2 ± 0.58
Parietal Lobe1.97 ± 0.63
Pontine Tegmentum1.98 ± 0.71
Striatum2.13 ± 0.6
Subthalamus2.11 ± 0.69
Temporal Lobe1.85 ± 0.61
Thalamus1.95 ± 0.63
White Matter2.42 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cpa3CBCerebellum2.74
2.84
Cpa3CTXCerebral cortex2.89
2.06
Cpa3HIPHippocampal region6.08
6.44
Cpa3HPFHippocampal formation4.63
4.45
Cpa3HYHypothalamus0.93
0.72
Cpa3LSXLateral septal complex0.24
0.13
Cpa3MBMidbrain0.46
0.53
Cpa3MYMedulla0.65
0.61
Cpa3OLFOlfactory bulb4.32
2.73
Cpa3PPons0.53
0.51
Cpa3PALPallidum2.18
2.15
Cpa3RHPRetrohippocampal region1.56
1.16
Cpa3sAMYStriatum-like amygdalar nuclei11.18
11.12
Cpa3STRStriatum2.19
1.88
Cpa3STRdStriatum dorsal region1.49
1.16
Cpa3STRvStriatum ventral region1.31
0.89
Cpa3THThalamus2.15
1.84
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CBPA3_HUMAN_145 14 145 158 IGSTVEDNPLYVLK PRIDE
CBPA3_HUMAN_333 9 333 341 IGTDVLSTR PRIDE
CBPA3_HUMAN_373 8 373 380 HTFAFELR PRIDE
CBPA3_HUMAN_385 9 385 393 FGFLLPESR PRIDE
PAp00136042 14 145 158 IGSTVEDNPLYVLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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