AutismKB 2.0

Annotation Detail for ADORA2B


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Basic Information Top
Gene Symbol:ADORA2B ( ADORA2 )
Gene Full Name: adenosine A2b receptor
Band: 17p12
Quick LinksEntrez ID:136; OMIM: 600446; Uniprot ID:AA2BR_HUMAN; ENSEMBL ID: ENSG00000170425; HGNC ID: 264
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult13 / 19391216
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal16 / 33603074
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain5 / 11009894
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye3 / 21105414
heart3 / 8962633
intestine1 / 2344724
kidney0 / 2117770 
larynx1 / 2414541
liver0 / 2077430 
lung2 / 3369745
lymph1 / 4427022
lymph node1 / 9161010
mammary gland0 / 1532710 
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach3 / 9661931
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205891_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.1
Adipocyte3.2
AdrenalCortex3.35
Adrenalgland2.7
Amygdala3.45
Appendix3.35
AtrioventricularNode2.6
BDCA4+_DentriticCells3.55
Bonemarrow3.15
BronchialEpithelialCells82.65
CD105+_Endothelial3.25
CD14+_Monocytes3.5
CD19+_BCells(neg._sel.)3.5
CD33+_Myeloid4.2
CD34+4.15
CD4+_Tcells3.5
CD56+_NKCells3.9
CD71+_EarlyErythroid3
CD8+_Tcells3.15
CardiacMyocytes121.4
Caudatenucleus2.9
Cerebellum2.65
CerebellumPeduncles3.65
CiliaryGanglion2.35
CingulateCortex3.4
Colorectaladenocarcinoma32.55
DorsalRootGanglion2.55
FetalThyroid3.15
Fetalbrain3.25
Fetalliver2.8
Fetallung2.7
GlobusPallidus2.4
Heart4.05
Hypothalamus3.55
Kidney2.65
Leukemia_chronicMyelogenousK-5622.95
Leukemia_promyelocytic-HL-602.85
Leukemialymphoblastic(MOLT-4)2.65
Liver4.2
Lung4.7
Lymphnode2.8
Lymphoma_burkitts(Daudi)4.1
Lymphoma_burkitts(Raji)4.5
MedullaOblongata3.1
OccipitalLobe2.95
OlfactoryBulb2.6
Ovary2.15
Pancreas2.6
PancreaticIslet3.45
ParietalLobe3.4
Pituitary3.8
Placenta3.4
Pons3.05
PrefrontalCortex4.2
Prostate3.8
Salivarygland2.6
SkeletalMuscle3.6
Skin2.7
SmoothMuscle202.45
Spinalcord3.45
SubthalamicNucleus3.1
SuperiorCervicalGanglion3.95
TemporalLobe2.95
Testis2.8
TestisGermCell2.75
TestisIntersitial2.7
TestisLeydigCell3.2
TestisSeminiferousTubule2.8
Thalamus3.25
Thymus2.6
Thyroid4.1
Tongue3.15
Tonsil3.15
Trachea2.7
TrigeminalGanglion3.4
Uterus2.65
UterusCorpus3
WholeBlood3.6
Wholebrain3.55
colon3.25
pineal_day4.06
pineal_night4
retina4.075
small_intestine3.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P55477
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.08 ± 0.38
Basal Forebrain7.26 ± 0.52
Basal Part of Pons5.64 ± 0.45
Cerebellar Cortex6.22 ± 0.3
Cerebellar Nuclei5.85 ± 0.6
Claustrum5.99 ± 0.87
Epithalamus6.24 ± 1.09
Frontal Lobe6.93 ± 0.54
Globus Pallidus5.87 ± 0.57
Hypothalamus6.5 ± 0.76
Insula6.99 ± 0.36
Limbic Lobe6.84 ± 0.75
Mesencephalon6.6 ± 0.65
Myelencephalon6.81 ± 0.87
Occipital Lobe6.89 ± 0.59
Parietal Lobe6.8 ± 0.69
Pontine Tegmentum6.94 ± 0.46
Striatum7.29 ± 0.45
Subthalamus5.62 ± 0.86
Temporal Lobe6.7 ± 0.59
Thalamus7.09 ± 0.63
White Matter4.03 ± 0.6
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Adora2bCBCerebellum11.61
15.99
Adora2bCTXCerebral cortex13.03
9.98
Adora2bHIPHippocampal region5.47
6.45
Adora2bHPFHippocampal formation4.72
5.15
Adora2bHYHypothalamus0.49
0.64
Adora2bLSXLateral septal complex1.45
1.02
Adora2bMBMidbrain1.46
1.86
Adora2bMYMedulla2.7
3.69
Adora2bOLFOlfactory bulb17.37
17.19
Adora2bPPons1.42
1.85
Adora2bPALPallidum1.26
1.22
Adora2bRHPRetrohippocampal region3.63
3.42
Adora2bsAMYStriatum-like amygdalar nuclei1.36
2.4
Adora2bSTRStriatum8.93
6.88
Adora2bSTRdStriatum dorsal region11.42
8.7
Adora2bSTRvStriatum ventral region5.75
4.45
Adora2bTHThalamus2.33
2.85
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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