AutismKB 2.0

Annotation Detail for CLDN3


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Basic Information Top
Gene Symbol:CLDN3 ( C7orf1,CPE-R2,CPETR2,HRVP1,RVP1 )
Gene Full Name: claudin 3
Band: 7q11.23
Quick LinksEntrez ID:1365; OMIM: 602910; Uniprot ID:CLD3_HUMAN; ENSEMBL ID: ENSG00000165215; HGNC ID: 2045
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus19 / 56401233
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult182 / 193912193
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor9 / 11424678
esophageal tumor0 / 172900 
gastrointestinal tumor13 / 119369108
germ cell tumor3 / 26384511
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia7 / 9725071
normal173 / 336030751
ovarian tumor19 / 76682247
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer7 / 10268068
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix4 / 4817183
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye4 / 21105418
heart1 / 8962611
intestine186 / 234472793
kidney29 / 211777136
larynx0 / 241450 
liver2 / 2077439
lung13 / 33697438
lymph0 / 442700 
lymph node5 / 9161054
mammary gland10 / 15327165
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary20 / 102051195
pancreas83 / 214812386
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate17 / 18934589
salivary gland2 / 2015599
skin0 / 2105740 
spleen0 / 539520 
stomach6 / 9661962
testis0 / 3304420 
thymus1 / 8113112
thyroid11 / 47473231
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus10 / 23287842
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203954_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.8
Adipocyte9.5
AdrenalCortex13
Adrenalgland8.7
Amygdala8.35
Appendix9.25
AtrioventricularNode8.4
BDCA4+_DentriticCells8.05
Bonemarrow9.75
BronchialEpithelialCells8.45
CD105+_Endothelial8.5
CD14+_Monocytes8.9
CD19+_BCells(neg._sel.)7.5
CD33+_Myeloid10.2
CD34+9.8
CD4+_Tcells8.5
CD56+_NKCells9.25
CD71+_EarlyErythroid9
CD8+_Tcells7.5
CardiacMyocytes12.9
Caudatenucleus8.65
Cerebellum7.9
CerebellumPeduncles25.1
CiliaryGanglion9.6
CingulateCortex9.75
Colorectaladenocarcinoma59.5
DorsalRootGanglion7.15
FetalThyroid56.35
Fetalbrain10.35
Fetalliver8.4
Fetallung17.15
GlobusPallidus7.35
Heart11.7
Hypothalamus10.45
Kidney15
Leukemia_chronicMyelogenousK-5627.85
Leukemia_promyelocytic-HL-608.05
Leukemialymphoblastic(MOLT-4)7.7
Liver42.8
Lung25.6
Lymphnode9.35
Lymphoma_burkitts(Daudi)12.2
Lymphoma_burkitts(Raji)13
MedullaOblongata8.75
OccipitalLobe8.5
OlfactoryBulb7.25
Ovary5.9
Pancreas127.35
PancreaticIslet36.15
ParietalLobe11.4
Pituitary17.85
Placenta9.75
Pons10.5
PrefrontalCortex10.3
Prostate735.75
Salivarygland8.65
SkeletalMuscle16.3
Skin8.3
SmoothMuscle10.6
Spinalcord10.15
SubthalamicNucleus8.95
SuperiorCervicalGanglion13
TemporalLobe9.45
Testis9.25
TestisGermCell7.5
TestisIntersitial8.15
TestisLeydigCell11.1
TestisSeminiferousTubule8.7
Thalamus9.9
Thymus8.25
Thyroid1076.1
Tongue10.35
Tonsil10.55
Trachea11.1
TrigeminalGanglion10.05
Uterus8.5
UterusCorpus11.95
WholeBlood9.25
Wholebrain7.55
colon492.2
pineal_day10.6
pineal_night11.2
retina11.475
small_intestine148.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P35109
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.08 ± 0.69
Basal Forebrain5.84 ± 0.22
Basal Part of Pons5.7 ± 0.44
Cerebellar Cortex5.63 ± 0.46
Cerebellar Nuclei6.13 ± 0.44
Claustrum6.35 ± 0.74
Epithalamus5.25 ± 0.7
Frontal Lobe5.87 ± 0.59
Globus Pallidus6.18 ± 0.45
Hypothalamus5.89 ± 0.47
Insula5.74 ± 0.34
Limbic Lobe5.88 ± 0.58
Mesencephalon6.13 ± 0.54
Myelencephalon5.97 ± 0.57
Occipital Lobe5.99 ± 0.55
Parietal Lobe5.94 ± 0.56
Pontine Tegmentum5.78 ± 0.51
Striatum6.2 ± 0.58
Subthalamus6.19 ± 0.41
Temporal Lobe5.85 ± 0.6
Thalamus6.05 ± 0.49
White Matter5.85 ± 0.27
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00739514 16 65 80 VYDSLLALPQDLQAAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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