AutismKB 2.0

Annotation Detail for LETM2


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Basic Information Top
Gene Symbol:LETM2 ( FLJ25409 )
Gene Full Name: leucine zipper-EF-hand containing transmembrane protein 2
Band: 8p11.23
Quick LinksEntrez ID:137994; OMIM: NA; Uniprot ID:LETM2_HUMAN; ENSEMBL ID: ENSG00000165046; HGNC ID: 14648
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult9 / 19391214
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal37 / 336030711
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow2 / 4880140
brain6 / 11009895
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye4 / 21105418
heart0 / 896260 
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver2 / 2077439
lung6 / 33697417
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis12 / 33044236
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_955_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.57 ± 0.79
Basal Forebrain4.31 ± 0.4
Basal Part of Pons3.89 ± 0.53
Cerebellar Cortex4.8 ± 0.28
Cerebellar Nuclei4.39 ± 0.57
Claustrum4.37 ± 0.72
Epithalamus4.28 ± 0.31
Frontal Lobe4.06 ± 0.6
Globus Pallidus3.9 ± 0.74
Hypothalamus4.27 ± 0.59
Insula3.87 ± 0.38
Limbic Lobe4.1 ± 0.57
Mesencephalon4.37 ± 0.64
Myelencephalon4.18 ± 0.57
Occipital Lobe4.43 ± 0.55
Parietal Lobe4.22 ± 0.6
Pontine Tegmentum4.29 ± 0.7
Striatum3.93 ± 0.62
Subthalamus4.43 ± 0.31
Temporal Lobe4.23 ± 0.62
Thalamus4.33 ± 0.61
White Matter3.48 ± 0.62
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
D030041N04RikCBCerebellum6.18
6.84
D030041N04RikCTXCerebral cortex7.35
5.13
D030041N04RikHIPHippocampal region4.59
4.34
D030041N04RikHPFHippocampal formation7.14
6.07
D030041N04RikHYHypothalamus2.53
1.71
D030041N04RikLSXLateral septal complex1.58
2.2
D030041N04RikMBMidbrain3.09
2.72
D030041N04RikMYMedulla9.18
9.09
D030041N04RikOLFOlfactory bulb12.81
10.1
D030041N04RikPPons6.01
5.51
D030041N04RikPALPallidum3.59
2.86
D030041N04RikRHPRetrohippocampal region11.52
8.58
D030041N04RiksAMYStriatum-like amygdalar nuclei0.51
0.38
D030041N04RikSTRStriatum2.49
2.16
D030041N04RikSTRdStriatum dorsal region2.47
1.8
D030041N04RikSTRvStriatum ventral region3.78
3.84
D030041N04RikTHThalamus3.44
2.43
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018