AutismKB 2.0

Annotation Detail for ATF2


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Basic Information Top
Gene Symbol:ATF2 ( CRE-BP1,CREB2,HB16,MGC111558,TREB7 )
Gene Full Name: activating transcription factor 2
Band: 2q31.1
Quick LinksEntrez ID:1386; OMIM: 123811; Uniprot ID:ATF2_HUMAN; ENSEMBL ID: ENSG00000115966; HGNC ID: 784
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst3 / 6231948
fetus23 / 56401240
neonate1 / 3109732
infant0 / 236200 
juvenile5 / 5555689
adult62 / 193912131
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor2 / 3436658
chondrosarcoma4 / 8282348
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor13 / 26384549
glioma1 / 1068839
head and neck tumor4 / 13630229
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor4 / 9635941
lung tumor3 / 10312729
lymphoma1 / 7175513
non-neoplasia5 / 9725051
normal141 / 336030741
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder1 / 2975733
blood3 / 12347824
bone2 / 7165527
bone marrow1 / 4880120
brain46 / 110098941
cervix2 / 4817141
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye7 / 21105433
heart1 / 8962611
intestine6 / 23447225
kidney5 / 21177723
larynx0 / 241450 
liver4 / 20774319
lung8 / 33697423
lymph0 / 442700 
lymph node4 / 9161043
mammary gland9 / 15327158
mouth2 / 6705229
muscle5 / 10771546
nerve3 / 15768190
ovary1 / 1020519
pancreas8 / 21481237
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta9 / 28082532
prostate3 / 18934515
salivary gland0 / 201550 
skin4 / 21057418
spleen3 / 5395255
stomach1 / 9661910
testis22 / 33044266
thymus1 / 8113112
thyroid2 / 4747342
tonsil0 / 169990 
trachea8 / 52413152
umbilical cord1 / 1368073
uterus13 / 23287855
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212984_at
Cell line Expression level Expression bar
721_B_lymphoblasts68.2
Adipocyte18.6
AdrenalCortex21.2
Adrenalgland17.2
Amygdala99.25
Appendix31.6
AtrioventricularNode21.9
BDCA4+_DentriticCells31
Bonemarrow17.45
BronchialEpithelialCells15
CD105+_Endothelial28.45
CD14+_Monocytes22.85
CD19+_BCells(neg._sel.)46.5
CD33+_Myeloid56.4
CD34+68.3
CD4+_Tcells31.85
CD56+_NKCells59.15
CD71+_EarlyErythroid13.7
CD8+_Tcells73.6
CardiacMyocytes27.05
Caudatenucleus23.3
Cerebellum13.85
CerebellumPeduncles21.1
CiliaryGanglion16.15
CingulateCortex24.75
Colorectaladenocarcinoma21.3
DorsalRootGanglion13.15
FetalThyroid23.35
Fetalbrain101.1
Fetalliver13.8
Fetallung15
GlobusPallidus17.5
Heart22.65
Hypothalamus48.6
Kidney13.75
Leukemia_chronicMyelogenousK-56217.45
Leukemia_promyelocytic-HL-6014.3
Leukemialymphoblastic(MOLT-4)25.7
Liver21.65
Lung15.55
Lymphnode20.4
Lymphoma_burkitts(Daudi)24.45
Lymphoma_burkitts(Raji)27.95
MedullaOblongata29.45
OccipitalLobe32.15
OlfactoryBulb14.5
Ovary13.75
Pancreas10.15
PancreaticIslet25.1
ParietalLobe19.45
Pituitary27.2
Placenta11.95
Pons16.6
PrefrontalCortex141.9
Prostate30.35
Salivarygland11.7
SkeletalMuscle23.9
Skin15.2
SmoothMuscle21.75
Spinalcord23.05
SubthalamicNucleus25.8
SuperiorCervicalGanglion23.4
TemporalLobe18
Testis10.2
TestisGermCell12.05
TestisIntersitial14.6
TestisLeydigCell16.3
TestisSeminiferousTubule13.6
Thalamus23.95
Thymus18.25
Thyroid127.5
Tongue16.25
Tonsil15.55
Trachea13.3
TrigeminalGanglion20.5
Uterus37.85
UterusCorpus18.2
WholeBlood38.35
Wholebrain27.9
colon41.65
pineal_day46.88
pineal_night50.36
retina23.5
small_intestine48.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P128145
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.66 ± 0.36
Basal Forebrain6.81 ± 0.13
Basal Part of Pons6.88 ± 0.36
Cerebellar Cortex6.91 ± 0.17
Cerebellar Nuclei6.45 ± 0.3
Claustrum6.73 ± 0.48
Epithalamus6.62 ± 0.4
Frontal Lobe6.62 ± 0.32
Globus Pallidus6.13 ± 0.4
Hypothalamus6.88 ± 0.3
Insula6.55 ± 0.41
Limbic Lobe6.72 ± 0.35
Mesencephalon6.58 ± 0.35
Myelencephalon6.64 ± 0.39
Occipital Lobe6.87 ± 0.27
Parietal Lobe6.76 ± 0.27
Pontine Tegmentum6.61 ± 0.41
Striatum6.41 ± 0.31
Subthalamus6.65 ± 0.53
Temporal Lobe6.75 ± 0.26
Thalamus6.63 ± 0.29
White Matter6.01 ± 0.1
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Atf2CBCerebellum40.07
51.4
Atf2CTXCerebral cortex100
100
Atf2HIPHippocampal region100
100
Atf2HPFHippocampal formation100
100
Atf2HYHypothalamus100
100
Atf2LSXLateral septal complex100
100
Atf2MBMidbrain95.51
98.92
Atf2MYMedulla62.36
77.72
Atf2OLFOlfactory bulb100
100
Atf2PPons67.96
82.65
Atf2PALPallidum100
100
Atf2RHPRetrohippocampal region100
100
Atf2sAMYStriatum-like amygdalar nuclei100
100
Atf2STRStriatum100
100
Atf2STRdStriatum dorsal region100
100
Atf2STRvStriatum ventral region100
100
Atf2THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00005700 21 78 98 NCEEVGLFNELASPFENEFKK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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