AutismKB 2.0

Annotation Detail for CREM


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Basic Information Top
Gene Symbol:CREM ( ICER,MGC111110,MGC17881,MGC41893,hCREM-2 )
Gene Full Name: cAMP responsive element modulator
Band: 10p11.21
Quick LinksEntrez ID:1390; OMIM: 123812; Uniprot ID:CREM_HUMAN; ENSEMBL ID: ENSG00000095794; HGNC ID: 2352
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst1 / 6231916
fetus21 / 56401237
neonate0 / 310970 
infant0 / 236200 
juvenile4 / 5555671
adult111 / 193912157
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor10 / 26384537
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor2 / 6895929
leukemia3 / 9584231
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal233 / 336030769
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland4 / 33197120
ascites0 / 400150 
bladder0 / 297570 
blood30 / 123478242
bone3 / 7165541
bone marrow4 / 4880181
brain42 / 110098938
cervix1 / 4817120
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus0 / 202090 
eye5 / 21105423
heart5 / 8962655
intestine4 / 23447217
kidney9 / 21177742
larynx3 / 24145124
liver6 / 20774328
lung12 / 33697435
lymph0 / 442700 
lymph node1 / 9161010
mammary gland11 / 15327171
mouth0 / 670520 
muscle0 / 1077150 
nerve2 / 15768126
ovary2 / 10205119
pancreas11 / 21481251
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta23 / 28082581
prostate10 / 18934552
salivary gland1 / 2015549
skin2 / 2105749
spleen0 / 539520 
stomach1 / 9661910
testis65 / 330442196
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209967_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts27.35
Adipocyte10.15
AdrenalCortex153.15
Adrenalgland77
Amygdala36.85
Appendix15.3
AtrioventricularNode12.8
BDCA4+_DentriticCells17.35
Bonemarrow12.05
BronchialEpithelialCells9.45
CD105+_Endothelial10.8
CD14+_Monocytes12
CD19+_BCells(neg._sel.)11.3
CD33+_Myeloid13.3
CD34+12
CD4+_Tcells11.75
CD56+_NKCells45.2
CD71+_EarlyErythroid10.7
CD8+_Tcells9.5
CardiacMyocytes17.25
Caudatenucleus10.6
Cerebellum9
CerebellumPeduncles13.35
CiliaryGanglion11.85
CingulateCortex12.8
Colorectaladenocarcinoma9.85
DorsalRootGanglion9.6
FetalThyroid12.55
Fetalbrain9.8
Fetalliver9.3
Fetallung12.65
GlobusPallidus9
Heart20.7
Hypothalamus23.25
Kidney9.95
Leukemia_chronicMyelogenousK-56210.5
Leukemia_promyelocytic-HL-6010.1
Leukemialymphoblastic(MOLT-4)7.4
Liver17.3
Lung11.85
Lymphnode8.25
Lymphoma_burkitts(Daudi)16.5
Lymphoma_burkitts(Raji)17.15
MedullaOblongata9.2
OccipitalLobe11.2
OlfactoryBulb14.3
Ovary12.1
Pancreas9.55
PancreaticIslet12.8
ParietalLobe12.4
Pituitary36.55
Placenta33.8
Pons11.65
PrefrontalCortex12.85
Prostate13.15
Salivarygland9.3
SkeletalMuscle15.35
Skin9.75
SmoothMuscle12.75
Spinalcord11.95
SubthalamicNucleus11.6
SuperiorCervicalGanglion17.6
TemporalLobe10.95
Testis29.85
TestisGermCell94.75
TestisIntersitial88.15
TestisLeydigCell37.7
TestisSeminiferousTubule16.6
Thalamus11.9
Thymus8.25
Thyroid22.9
Tongue12.65
Tonsil11.15
Trachea8.55
TrigeminalGanglion16.25
Uterus21.2
UterusCorpus14.55
WholeBlood12.7
Wholebrain19.8
colon10.05
pineal_day289.14
pineal_night505.8
retina14.55
small_intestine9.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14775_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.94 ± 0.15
Basal Forebrain6.85 ± 0.25
Basal Part of Pons6.31 ± 0.18
Cerebellar Cortex6.44 ± 0.25
Cerebellar Nuclei7.01 ± 0.3
Claustrum6.69 ± 0.47
Epithalamus7.23 ± 0.28
Frontal Lobe6.69 ± 0.33
Globus Pallidus7.24 ± 0.13
Hypothalamus6.92 ± 0.4
Insula6.73 ± 0.27
Limbic Lobe6.75 ± 0.36
Mesencephalon6.85 ± 0.29
Myelencephalon6.73 ± 0.41
Occipital Lobe6.52 ± 0.29
Parietal Lobe6.7 ± 0.4
Pontine Tegmentum6.88 ± 0.36
Striatum7.36 ± 0.45
Subthalamus6.92 ± 0.24
Temporal Lobe6.72 ± 0.33
Thalamus6.61 ± 0.33
White Matter7.55 ± 0.43
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
CremCBCerebellum0.83
0.99
CremCTXCerebral cortex5.96
3.9
CremHIPHippocampal region5.74
4.74
CremHPFHippocampal formation8.46
6.55
CremHYHypothalamus3.23
5.3
CremLSXLateral septal complex0
0
CremMBMidbrain1.02
1.16
CremMYMedulla0.98
1.34
CremOLFOlfactory bulb6.77
5.62
CremPPons3.02
4.19
CremPALPallidum3.09
2.7
CremRHPRetrohippocampal region15.07
10.55
CremsAMYStriatum-like amygdalar nuclei6.82
4.43
CremSTRStriatum3.7
2.62
CremSTRdStriatum dorsal region3.61
2.5
CremSTRvStriatum ventral region3.27
2.79
CremTHThalamus1.06
0.75
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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