AutismKB 2.0

Annotation Detail for CRK


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Basic Information Top
Gene Symbol:CRK ( CRKII )
Gene Full Name: v-crk sarcoma virus CT10 oncogene homolog (avian)
Band: 17p13.3
Quick LinksEntrez ID:1398; OMIM: 164762; Uniprot ID:CRK_HUMAN; ENSEMBL ID: ENSG00000167193; HGNC ID: 2362
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst3 / 6231948
fetus25 / 56401244
neonate2 / 3109764
infant1 / 2362042
juvenile0 / 555560 
adult67 / 193912134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor10 / 94178106
cervical tumor4 / 34366116
chondrosarcoma0 / 828230 
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor15 / 26384556
glioma4 / 10688337
head and neck tumor5 / 13630236
kidney tumor3 / 6895943
leukemia4 / 9584241
liver tumor6 / 9635962
lung tumor5 / 10312748
lymphoma5 / 7175569
non-neoplasia2 / 9725020
normal127 / 336030737
ovarian tumor6 / 7668278
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites3 / 4001574
bladder0 / 297570 
blood5 / 12347840
bone4 / 7165555
bone marrow2 / 4880140
brain61 / 110098955
cervix4 / 4817183
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus0 / 202090 
eye8 / 21105437
heart1 / 8962611
intestine10 / 23447242
kidney4 / 21177718
larynx0 / 241450 
liver7 / 20774333
lung11 / 33697432
lymph4 / 4427090
lymph node3 / 9161032
mammary gland11 / 15327171
mouth4 / 6705259
muscle1 / 1077159
nerve0 / 157680 
ovary6 / 10205158
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta22 / 28082578
prostate0 / 1893450 
salivary gland0 / 201550 
skin7 / 21057433
spleen3 / 5395255
stomach2 / 9661920
testis9 / 33044227
thymus3 / 8113136
thyroid3 / 4747363
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus9 / 23287838
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202226_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts11
Adipocyte12.2
AdrenalCortex8.8
Adrenalgland7.9
Amygdala9.6
Appendix11.15
AtrioventricularNode6.5
BDCA4+_DentriticCells9.3
Bonemarrow8.45
BronchialEpithelialCells8.7
CD105+_Endothelial8.7
CD14+_Monocytes8.65
CD19+_BCells(neg._sel.)9.3
CD33+_Myeloid12
CD34+13.65
CD4+_Tcells9.4
CD56+_NKCells9.8
CD71+_EarlyErythroid7.9
CD8+_Tcells8.2
CardiacMyocytes15.05
Caudatenucleus7.75
Cerebellum7.1
CerebellumPeduncles11.85
CiliaryGanglion5.35
CingulateCortex8.75
Colorectaladenocarcinoma15.45
DorsalRootGanglion6.3
FetalThyroid8.25
Fetalbrain10.15
Fetalliver7.45
Fetallung8.1
GlobusPallidus6.4
Heart10.85
Hypothalamus9.75
Kidney6.95
Leukemia_chronicMyelogenousK-5627.85
Leukemia_promyelocytic-HL-607.6
Leukemialymphoblastic(MOLT-4)6.9
Liver11.45
Lung12.5
Lymphnode7.5
Lymphoma_burkitts(Daudi)10.85
Lymphoma_burkitts(Raji)11.65
MedullaOblongata8.15
OccipitalLobe9.15
OlfactoryBulb7.1
Ovary5.8
Pancreas7.2
PancreaticIslet11.8
ParietalLobe9.35
Pituitary10.25
Placenta10.2
Pons10.15
PrefrontalCortex9.55
Prostate19.6
Salivarygland6.95
SkeletalMuscle10.15
Skin6.4
SmoothMuscle15.3
Spinalcord9.05
SubthalamicNucleus7.7
SuperiorCervicalGanglion9.8
TemporalLobe7.95
Testis6.7
TestisGermCell7.7
TestisIntersitial6.45
TestisLeydigCell8.4
TestisSeminiferousTubule7
Thalamus8.8
Thymus6.9
Thyroid11
Tongue8.35
Tonsil10.4
Trachea7.3
TrigeminalGanglion8.45
Uterus7.2
UterusCorpus7.5
WholeBlood10.05
Wholebrain7.45
colon8.85
pineal_day10.7
pineal_night10.48
retina10.575
small_intestine8.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P83556
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.54 ± 0.75
Basal Forebrain3.09 ± 0.42
Basal Part of Pons3.61 ± 0.35
Cerebellar Cortex3.85 ± 0.41
Cerebellar Nuclei3.49 ± 0.55
Claustrum3.46 ± 0.61
Epithalamus3.5 ± 0.56
Frontal Lobe3.71 ± 0.54
Globus Pallidus2.97 ± 0.71
Hypothalamus3.15 ± 0.5
Insula3.54 ± 0.52
Limbic Lobe3.59 ± 0.51
Mesencephalon3.52 ± 0.54
Myelencephalon3.51 ± 0.59
Occipital Lobe3.16 ± 0.67
Parietal Lobe3.35 ± 0.5
Pontine Tegmentum3.59 ± 0.65
Striatum3.07 ± 0.67
Subthalamus3.85 ± 0.15
Temporal Lobe3.65 ± 0.52
Thalamus3.45 ± 0.59
White Matter3.64 ± 0.51
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CRK_HUMAN_17 14 17 30 LSRQEAVALLQGQR PRIDE
CRK_HUMAN_2 9 2 10 AGNFDSEER PRIDE
CRK_HUMAN_88 17 88 104 IGDQEFDSLPALLEFYK PRIDE
PAp00070268 17 89 105 IGDQEFDSLPALLEFYK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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