AutismKB 2.0

Annotation Detail for CRKL


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Basic Information Top
Gene Symbol:CRKL ( - )
Gene Full Name: v-crk sarcoma virus CT10 oncogene homolog (avian)-like
Band: 22q11.21
Quick LinksEntrez ID:1399; OMIM: 602007; Uniprot ID:CRKL_HUMAN; ENSEMBL ID: ENSG00000099942; HGNC ID: 2363
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst9 / 62319144
fetus42 / 56401274
neonate0 / 310970 
infant2 / 2362084
juvenile3 / 5555653
adult163 / 193912184
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor5 / 9417853
cervical tumor1 / 3436629
chondrosarcoma9 / 82823108
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor14 / 119369117
germ cell tumor18 / 26384568
glioma4 / 10688337
head and neck tumor11 / 13630280
kidney tumor7 / 68959101
leukemia6 / 9584262
liver tumor4 / 9635941
lung tumor1 / 1031279
lymphoma3 / 7175541
non-neoplasia4 / 9725041
normal289 / 336030786
ovarian tumor0 / 766820 
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer21 / 102680204
retinoblastoma1 / 4635621
skin tumor4 / 12494932
soft tissue/muscle tissue tumor11 / 12519187
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites3 / 4001574
bladder4 / 29757134
blood4 / 12347832
bone5 / 7165569
bone marrow7 / 48801143
brain89 / 110098980
cervix1 / 4817120
connective tissue12 / 14925580
ear2 / 16212123
embryonic tissue24 / 215722111
esophagus0 / 202090 
eye18 / 21105485
heart4 / 8962644
intestine15 / 23447263
kidney13 / 21177761
larynx0 / 241450 
liver6 / 20774328
lung20 / 33697459
lymph2 / 4427045
lymph node9 / 9161098
mammary gland11 / 15327171
mouth8 / 67052119
muscle6 / 10771555
nerve2 / 15768126
ovary1 / 1020519
pancreas14 / 21481265
parathyroid3 / 20539146
pharynx3 / 4132872
pituitary gland1 / 1658560
placenta13 / 28082546
prostate24 / 189345126
salivary gland2 / 2015599
skin14 / 21057466
spleen1 / 5395218
stomach28 / 96619289
testis24 / 33044272
thymus11 / 81131135
thyroid1 / 4747321
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus22 / 23287894
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212180_at
Cell line Expression level Expression bar
721_B_lymphoblasts347.1
Adipocyte41.5
AdrenalCortex19.3
Adrenalgland30.25
Amygdala75.2
Appendix21.75
AtrioventricularNode8.3
BDCA4+_DentriticCells226.25
Bonemarrow78.05
BronchialEpithelialCells147.65
CD105+_Endothelial173.45
CD14+_Monocytes176.45
CD19+_BCells(neg._sel.)243.85
CD33+_Myeloid219.45
CD34+269.35
CD4+_Tcells262.9
CD56+_NKCells357.55
CD71+_EarlyErythroid374.3
CD8+_Tcells209.2
CardiacMyocytes74.75
Caudatenucleus49.6
Cerebellum126
CerebellumPeduncles115
CiliaryGanglion8.65
CingulateCortex88.75
Colorectaladenocarcinoma47
DorsalRootGanglion14.35
FetalThyroid31
Fetalbrain50.85
Fetalliver78.7
Fetallung54.85
GlobusPallidus24.6
Heart36.1
Hypothalamus130.35
Kidney22.35
Leukemia_chronicMyelogenousK-562574
Leukemia_promyelocytic-HL-6054.3
Leukemialymphoblastic(MOLT-4)162.7
Liver41.15
Lung58.75
Lymphnode39.85
Lymphoma_burkitts(Daudi)86.6
Lymphoma_burkitts(Raji)87.05
MedullaOblongata59.9
OccipitalLobe91.7
OlfactoryBulb54.15
Ovary13.45
Pancreas35.5
PancreaticIslet66.1
ParietalLobe67.7
Pituitary59.95
Placenta182.65
Pons47.55
PrefrontalCortex234.9
Prostate38.55
Salivarygland43.65
SkeletalMuscle54.85
Skin13.75
SmoothMuscle115.1
Spinalcord63.8
SubthalamicNucleus48
SuperiorCervicalGanglion30.1
TemporalLobe49.85
Testis38.6
TestisGermCell38.35
TestisIntersitial30.05
TestisLeydigCell17.05
TestisSeminiferousTubule34.45
Thalamus62
Thymus130
Thyroid46.1
Tongue42.8
Tonsil63.15
Trachea35.55
TrigeminalGanglion28.35
Uterus50.3
UterusCorpus28.3
WholeBlood212.85
Wholebrain100.5
colon42.9
pineal_day181.84
pineal_night181.62
retina164.2
small_intestine70.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P40535
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.34 ± 0.38
Basal Forebrain8.19 ± 0.35
Basal Part of Pons7.99 ± 0.33
Cerebellar Cortex8.28 ± 0.3
Cerebellar Nuclei8.3 ± 0.34
Claustrum8.72 ± 0.55
Epithalamus8.02 ± 0.21
Frontal Lobe8.12 ± 0.4
Globus Pallidus8.36 ± 0.14
Hypothalamus8.15 ± 0.38
Insula8.04 ± 0.28
Limbic Lobe8.21 ± 0.45
Mesencephalon8.31 ± 0.41
Myelencephalon8.21 ± 0.35
Occipital Lobe8.33 ± 0.32
Parietal Lobe8.23 ± 0.38
Pontine Tegmentum8.17 ± 0.41
Striatum7.68 ± 0.36
Subthalamus8.31 ± 0.18
Temporal Lobe8.05 ± 0.33
Thalamus8.2 ± 0.31
White Matter8.71 ± 0.42
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
CrklCBCerebellum21.65
71.45
CrklCTXCerebral cortex75.66
61.02
CrklHIPHippocampal region48.28
90.62
CrklHPFHippocampal formation50.52
69.76
CrklHYHypothalamus12
9.66
CrklLSXLateral septal complex9.44
7.16
CrklMBMidbrain17.43
18.04
CrklMYMedulla24.77
30.76
CrklOLFOlfactory bulb64.93
57.48
CrklPPons22.95
26.36
CrklPALPallidum12.88
12.4
CrklRHPRetrohippocampal region54.64
47.03
CrklsAMYStriatum-like amygdalar nuclei8.42
6.29
CrklSTRStriatum7.6
6.4
CrklSTRdStriatum dorsal region7.56
6.79
CrklSTRvStriatum ventral region6.25
4.68
CrklTHThalamus22.9
20.15
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CRKL_HUMAN_11 10 11 20 SAWYMGPVSR PRIDE
CRKL_HUMAN_129 16 129 144 TLYDFPGNDAEDLPFK PRIDE
CRKL_HUMAN_265 17 265 281 VTRMNINGQWEGEVNGR PRIDE
CRKL_HUMAN_70 19 70 88 FKIGDQEFDHLPALLEFYK PRIDE
CRKL_HUMAN_72 17 72 88 IGDQEFDHLPALLEFYK PRIDE
CRKL_HUMAN_89 15 89 103 IHYLDTTTLIEPAPR PRIDE
PAp00001805 18 40 57 DSSTCPGDYVLSVSENSR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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