AutismKB 2.0

Annotation Detail for PARP1


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Basic Information Top
Gene Symbol:PARP1 ( ADPRT,ADPRT 1,ADPRT1,PARP,PARP-1,PPOL,pADPRT-1 )
Gene Full Name: poly (ADP-ribose) polymerase 1
Band: 1q42.12
Quick LinksEntrez ID:142; OMIM: 173870; Uniprot ID:PARP1_HUMAN; ENSEMBL ID: ENSG00000143799; HGNC ID: 270
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body22 / 70761310
blastocyst37 / 62319593
fetus82 / 564012145
neonate2 / 3109764
infant5 / 23620211
juvenile10 / 55556179
adult268 / 1939121138
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma2 / 17475114
breast (mammary gland) tumor19 / 94178201
cervical tumor8 / 34366232
chondrosarcoma10 / 82823120
colorectal tumor34 / 114246297
esophageal tumor3 / 17290173
gastrointestinal tumor12 / 119369100
germ cell tumor94 / 263845356
glioma4 / 10688337
head and neck tumor18 / 136302132
kidney tumor10 / 68959145
leukemia12 / 95842125
liver tumor10 / 96359103
lung tumor15 / 103127145
lymphoma51 / 71755710
non-neoplasia16 / 97250164
normal596 / 3360307177
ovarian tumor11 / 76682143
pancreatic tumor9 / 10461686
primitive neuroectodermal tumor of the CNS26 / 125680206
prostate cancer29 / 102680282
retinoblastoma19 / 46356409
skin tumor42 / 124949336
soft tissue/muscle tissue tumor27 / 125191215
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland6 / 33197180
ascites3 / 4001574
bladder6 / 29757201
blood13 / 123478105
bone6 / 7165583
bone marrow2 / 4880140
brain216 / 1100989196
cervix8 / 48171166
connective tissue12 / 14925580
ear1 / 1621261
embryonic tissue80 / 215722370
esophagus3 / 20209148
eye43 / 211054203
heart8 / 8962689
intestine47 / 234472200
kidney24 / 211777113
larynx4 / 24145165
liver28 / 207743134
lung48 / 336974142
lymph38 / 44270858
lymph node41 / 91610447
mammary gland20 / 153271130
mouth12 / 67052178
muscle18 / 107715167
nerve3 / 15768190
ovary16 / 102051156
pancreas42 / 214812195
parathyroid5 / 20539243
pharynx4 / 4132896
pituitary gland3 / 16585180
placenta40 / 280825142
prostate36 / 189345190
salivary gland0 / 201550 
skin47 / 210574223
spleen4 / 5395274
stomach2 / 9661920
testis110 / 330442332
thymus9 / 81131110
thyroid2 / 4747342
tonsil6 / 16999352
trachea19 / 52413362
umbilical cord0 / 136800 
uterus36 / 232878154
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208644_at
Cell line Expression level Expression bar
721_B_lymphoblasts1213.8
Adipocyte75.85
AdrenalCortex31.5
Adrenalgland65.25
Amygdala149.75
Appendix87.9
AtrioventricularNode34
BDCA4+_DentriticCells280.35
Bonemarrow117.6
BronchialEpithelialCells130.1
CD105+_Endothelial310.15
CD14+_Monocytes94.75
CD19+_BCells(neg._sel.)763.45
CD33+_Myeloid115.2
CD34+873.35
CD4+_Tcells316.05
CD56+_NKCells358.9
CD71+_EarlyErythroid129.9
CD8+_Tcells229.35
CardiacMyocytes52.65
Caudatenucleus127.2
Cerebellum117.25
CerebellumPeduncles151.7
CiliaryGanglion38.65
CingulateCortex152.4
Colorectaladenocarcinoma154.65
DorsalRootGanglion90.4
FetalThyroid114.8
Fetalbrain153.35
Fetalliver146.2
Fetallung107.5
GlobusPallidus91.4
Heart67.95
Hypothalamus239.9
Kidney53.55
Leukemia_chronicMyelogenousK-562295.5
Leukemia_promyelocytic-HL-60519.45
Leukemialymphoblastic(MOLT-4)188.5
Liver80.25
Lung87.95
Lymphnode175.95
Lymphoma_burkitts(Daudi)833.25
Lymphoma_burkitts(Raji)469.15
MedullaOblongata119.1
OccipitalLobe170.5
OlfactoryBulb167.5
Ovary19.15
Pancreas87.3
PancreaticIslet152.15
ParietalLobe153.7
Pituitary217.75
Placenta143
Pons91.25
PrefrontalCortex181.2
Prostate133.65
Salivarygland69.9
SkeletalMuscle91.55
Skin66.25
SmoothMuscle88.6
Spinalcord316.4
SubthalamicNucleus118.9
SuperiorCervicalGanglion51.45
TemporalLobe108.05
Testis168.85
TestisGermCell150.6
TestisIntersitial118.7
TestisLeydigCell100.95
TestisSeminiferousTubule133
Thalamus201.85
Thymus182.05
Thyroid63.6
Tongue50.4
Tonsil373.25
Trachea70.35
TrigeminalGanglion24
Uterus52.35
UterusCorpus32.4
WholeBlood105.45
Wholebrain196.1
colon70.05
pineal_day602.52
pineal_night440.62
retina204.5
small_intestine130.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P114783
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10 ± 0.23
Basal Forebrain9.94 ± 0.19
Basal Part of Pons10.05 ± 0.17
Cerebellar Cortex9.79 ± 0.1
Cerebellar Nuclei10.22 ± 0.14
Claustrum9.98 ± 0.21
Epithalamus9.92 ± 0.22
Frontal Lobe10.09 ± 0.25
Globus Pallidus10.53 ± 0.18
Hypothalamus9.85 ± 0.18
Insula10.13 ± 0.24
Limbic Lobe9.99 ± 0.27
Mesencephalon10.06 ± 0.29
Myelencephalon10.03 ± 0.23
Occipital Lobe9.89 ± 0.17
Parietal Lobe9.99 ± 0.21
Pontine Tegmentum10.05 ± 0.25
Striatum10.24 ± 0.21
Subthalamus10.09 ± 0.28
Temporal Lobe10.01 ± 0.17
Thalamus10.07 ± 0.21
White Matter10.99 ± 0.09
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Parp1CBCerebellum22.72
63.58
Parp1CTXCerebral cortex54.17
44.19
Parp1HIPHippocampal region65.54
100
Parp1HPFHippocampal formation56.67
84.54
Parp1HYHypothalamus4.88
3.8
Parp1LSXLateral septal complex25.71
20.77
Parp1MBMidbrain9.93
9.8
Parp1MYMedulla21.1
25.92
Parp1OLFOlfactory bulb60.92
55.97
Parp1PPons9.84
11.53
Parp1PALPallidum10.72
9.14
Parp1RHPRetrohippocampal region42.93
39.3
Parp1sAMYStriatum-like amygdalar nuclei13.96
9.95
Parp1STRStriatum21.19
15.49
Parp1STRdStriatum dorsal region22.13
16.32
Parp1STRvStriatum ventral region20.25
13.81
Parp1THThalamus54.65
51.08
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PARP1_HUMAN_1 9 1 9 AESSDKLYR PRIDE
PARP1_HUMAN_142 14 142 155 MVDPEKPQLGMIDR PRIDE
PARP1_HUMAN_2 9 2 10 AESSDKLYR PRIDE
PARP1_HUMAN_600 16 600 615 LEQMPSKEDAIEHFMK PRIDE
PAp00000595 11 685 695 AMVEYEIDLQK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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