AutismKB 2.0

Annotation Detail for CS


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Basic Information Top
Gene Symbol:CS ( - )
Gene Full Name: citrate synthase
Band: 12q13.3
Quick LinksEntrez ID:1431; OMIM: 118950; Uniprot ID:CISY_HUMAN; ENSEMBL ID: ENSG00000062485; HGNC ID: 2422
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst10 / 62319160
fetus215 / 564012381
neonate11 / 31097353
infant7 / 23620296
juvenile17 / 55556305
adult361 / 1939121186
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor13 / 94178138
cervical tumor5 / 34366145
chondrosarcoma20 / 82823241
colorectal tumor20 / 114246175
esophageal tumor4 / 17290231
gastrointestinal tumor20 / 119369167
germ cell tumor126 / 263845477
glioma16 / 106883149
head and neck tumor84 / 136302616
kidney tumor11 / 68959159
leukemia32 / 95842333
liver tumor22 / 96359228
lung tumor29 / 103127281
lymphoma32 / 71755445
non-neoplasia15 / 97250154
normal741 / 3360307220
ovarian tumor24 / 76682312
pancreatic tumor31 / 104616296
primitive neuroectodermal tumor of the CNS61 / 125680485
prostate cancer28 / 102680272
retinoblastoma23 / 46356496
skin tumor15 / 124949120
soft tissue/muscle tissue tumor16 / 125191127
uterine tumor12 / 90257132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland3 / 3319790
ascites8 / 40015199
bladder2 / 2975767
blood31 / 123478251
bone14 / 71655195
bone marrow13 / 48801266
brain422 / 1100989383
cervix9 / 48171186
connective tissue27 / 149255180
ear0 / 162120 
embryonic tissue29 / 215722134
esophagus4 / 20209197
eye44 / 211054208
heart28 / 89626312
intestine49 / 234472208
kidney39 / 211777184
larynx1 / 2414541
liver37 / 207743178
lung61 / 336974181
lymph26 / 44270587
lymph node25 / 91610272
mammary gland30 / 153271195
mouth74 / 670521103
muscle21 / 107715194
nerve1 / 1576863
ovary28 / 102051274
pancreas36 / 214812167
parathyroid2 / 2053997
pharynx7 / 41328169
pituitary gland4 / 16585241
placenta32 / 280825113
prostate31 / 189345163
salivary gland11 / 20155545
skin47 / 210574223
spleen17 / 53952315
stomach11 / 96619113
testis105 / 330442317
thymus111 / 811311368
thyroid7 / 47473147
tonsil3 / 16999176
trachea15 / 52413286
umbilical cord2 / 13680146
uterus41 / 232878176
vascular25 / 51780482
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208660_at
Cell line Expression level Expression bar
721_B_lymphoblasts2091.85
Adipocyte1199.95
AdrenalCortex291.85
Adrenalgland523.1
Amygdala358.2
Appendix145.75
AtrioventricularNode103.6
BDCA4+_DentriticCells620.6
Bonemarrow448.2
BronchialEpithelialCells598.95
CD105+_Endothelial532.05
CD14+_Monocytes632.35
CD19+_BCells(neg._sel.)664.25
CD33+_Myeloid766.4
CD34+813.55
CD4+_Tcells450.1
CD56+_NKCells497.1
CD71+_EarlyErythroid284.7
CD8+_Tcells362.5
CardiacMyocytes473.8
Caudatenucleus299.15
Cerebellum599.85
CerebellumPeduncles584.05
CiliaryGanglion159.45
CingulateCortex426.45
Colorectaladenocarcinoma542.85
DorsalRootGanglion216.5
FetalThyroid402.95
Fetalbrain530.85
Fetalliver241.75
Fetallung329.95
GlobusPallidus358.6
Heart1147.85
Hypothalamus461.2
Kidney330.9
Leukemia_chronicMyelogenousK-562736.35
Leukemia_promyelocytic-HL-601012.8
Leukemialymphoblastic(MOLT-4)537
Liver189.95
Lung377.3
Lymphnode327.05
Lymphoma_burkitts(Daudi)1367.75
Lymphoma_burkitts(Raji)1154.05
MedullaOblongata400.65
OccipitalLobe402.3
OlfactoryBulb236.75
Ovary177
Pancreas192.95
PancreaticIslet345.85
ParietalLobe404.85
Pituitary371.95
Placenta295.95
Pons304.1
PrefrontalCortex776.7
Prostate303.45
Salivarygland396.45
SkeletalMuscle629.45
Skin228.3
SmoothMuscle412.2
Spinalcord313.85
SubthalamicNucleus353.8
SuperiorCervicalGanglion59.6
TemporalLobe290.25
Testis258.25
TestisGermCell138
TestisIntersitial70.25
TestisLeydigCell106.75
TestisSeminiferousTubule92.95
Thalamus562.8
Thymus424.05
Thyroid378.8
Tongue528.55
Tonsil399.4
Trachea229.9
TrigeminalGanglion198.35
Uterus219.35
UterusCorpus120.2
WholeBlood463.8
Wholebrain389.7
colon430.15
pineal_day745.38
pineal_night716.98
retina609.55
small_intestine399.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7966_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.51 ± 0.64
Basal Forebrain4.65 ± 0.48
Basal Part of Pons5.06 ± 0.41
Cerebellar Cortex4.82 ± 0.44
Cerebellar Nuclei5 ± 0.5
Claustrum4.36 ± 0.84
Epithalamus4.61 ± 0.21
Frontal Lobe4.66 ± 0.54
Globus Pallidus4.17 ± 0.63
Hypothalamus4.38 ± 0.46
Insula4.69 ± 0.4
Limbic Lobe4.46 ± 0.48
Mesencephalon4.72 ± 0.53
Myelencephalon4.58 ± 0.5
Occipital Lobe4.84 ± 0.54
Parietal Lobe4.81 ± 0.49
Pontine Tegmentum4.66 ± 0.48
Striatum4.39 ± 0.53
Subthalamus4.64 ± 0.51
Temporal Lobe4.67 ± 0.4
Thalamus4.95 ± 0.59
White Matter3.84 ± 0.43
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
CsCBCerebellum49.44
100
CsCTXCerebral cortex100
100
CsHIPHippocampal region100
100
CsHPFHippocampal formation100
100
CsHYHypothalamus96.89
100
CsLSXLateral septal complex100
100
CsMBMidbrain86.79
98.54
CsMYMedulla92.18
100
CsOLFOlfactory bulb100
100
CsPPons87.64
100
CsPALPallidum98.82
100
CsRHPRetrohippocampal region100
100
CssAMYStriatum-like amygdalar nuclei100
100
CsSTRStriatum97.12
94.72
CsSTRdStriatum dorsal region89.82
84.39
CsSTRvStriatum ventral region100
100
CsTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CISY_HUMAN_0 0 0 0 AALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESNFAR PRIDE
CISY_HUMAN_0 0 0 0 ALGVLAQLIWSR PRIDE
CISY_HUMAN_0 0 0 0 GLVYETSVLDPDEGIR PRIDE
CISY_HUMAN_144 39 144 182 AALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESNFAR PRIDE
CISY_HUMAN_166 18 166 183 SQLSAAVTALNSESNFAR PRIDE
CISY_HUMAN_222 34 222 255 EGSGIGAIDSNLDWSHNFTNMLGYTDHQFTELTR PRIDE
CISY_HUMAN_26 22 26 47 ASASSTNLKDILADLIPKEQAR PRIDE
CISY_HUMAN_329 11 329 339 DYIWNTLNSGR PRIDE
CISY_HUMAN_340 11 340 350 VVPGYGHAVLR PRIDE
CISY_HUMAN_341 11 341 351 VVPGYGHAVLR PRIDE
CISY_HUMAN_343 9 343 351 PGYGHAVLR PRIDE
CISY_HUMAN_367 9 367 375 HLPNDPMFK PRIDE
CISY_HUMAN_382 11 382 392 IVPNVLLEQGK PRIDE
CISY_HUMAN_383 11 383 393 IVPNVLLEQGK PRIDE
CISY_HUMAN_428 12 428 439 ALGVLAQLIWSR PRIDE
CISY_HUMAN_441 10 441 450 ALGFPLERPK PRIDE
CISY_HUMAN_443 8 443 450 GFPLERPK PRIDE
CISY_HUMAN_57 35 57 91 TVVGQITVDMMYGGMRGMKGLVYETSVLDPDEGIR PRIDE
CISY_HUMAN_58 16 58 73 TVVGQITVDMMYGGMR PRIDE
CISY_HUMAN_76 16 76 91 GLVYETSVLDPDEGIR PRIDE
CISY_HUMAN_77 16 77 92 GLVYETSVLDPDEGIR PRIDE
CISY_HUMAN_94 9 94 102 GFSIPECQK PRIDE
CISY_HUMAN_95 9 95 103 GFSIPECQK PRIDE
PAp00002041 34 223 256 EGSGIGAIDSNLDWSHNFTNMLGYTDHQFTELTR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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