AutismKB 2.0

Annotation Detail for PLEKHA7


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Basic Information Top
Gene Symbol:PLEKHA7 ( DKFZp686M22243 )
Gene Full Name: pleckstrin homology domain containing, family A member 7
Band: 11p15
Quick LinksEntrez ID:144100; OMIM: 612686; Uniprot ID:PKHA7_HUMAN; ENSEMBL ID: ENSG00000166689; HGNC ID: 27049
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst1 / 6231916
fetus12 / 56401221
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult57 / 193912129
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor2 / 2638457
glioma4 / 10688337
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal87 / 336030725
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone1 / 7165513
bone marrow0 / 488010 
brain23 / 110098920
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye6 / 21105428
heart2 / 8962622
intestine8 / 23447234
kidney9 / 21177742
larynx1 / 2414541
liver0 / 2077430 
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland4 / 15327126
mouth0 / 670520 
muscle1 / 1077159
nerve1 / 1576863
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate6 / 18934531
salivary gland0 / 201550 
skin5 / 21057423
spleen0 / 539520 
stomach1 / 9661910
testis7 / 33044221
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus8 / 23287834
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P109487
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.56 ± 0.99
Basal Forebrain2.5 ± 0.62
Basal Part of Pons1.75 ± 0.46
Cerebellar Cortex2.11 ± 0.62
Cerebellar Nuclei2.43 ± 0.76
Claustrum2.88 ± 0.89
Epithalamus3.5 ± 0.72
Frontal Lobe2.23 ± 0.69
Globus Pallidus3.27 ± 0.74
Hypothalamus2.11 ± 0.71
Insula2.23 ± 0.69
Limbic Lobe2.23 ± 0.72
Mesencephalon2.6 ± 0.7
Myelencephalon2.51 ± 0.84
Occipital Lobe2.65 ± 0.97
Parietal Lobe2.37 ± 0.76
Pontine Tegmentum2.53 ± 0.84
Striatum3.55 ± 0.77
Subthalamus2.11 ± 0.61
Temporal Lobe2.24 ± 0.78
Thalamus2.87 ± 0.69
White Matter2.89 ± 0.58
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Plekha7CBCerebellum18.52
33.67
Plekha7CTXCerebral cortex56.78
54.58
Plekha7HIPHippocampal region26.56
34.18
Plekha7HPFHippocampal formation42.8
45.95
Plekha7HYHypothalamus47.49
42.68
Plekha7LSXLateral septal complex73.75
64.87
Plekha7MBMidbrain41.94
39.78
Plekha7MYMedulla33.23
35.51
Plekha7OLFOlfactory bulb55.84
52.52
Plekha7PPons35.39
36.84
Plekha7PALPallidum40.96
40.35
Plekha7RHPRetrohippocampal region66.19
61.59
Plekha7sAMYStriatum-like amygdalar nuclei48.97
38.49
Plekha7STRStriatum31.55
25.14
Plekha7STRdStriatum dorsal region20.45
16.08
Plekha7STRvStriatum ventral region35.85
27.13
Plekha7THThalamus79.35
77.78
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00499927 20 534 553 HGSPTAPICLGSPEFTDQGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018