AutismKB 2.0

Annotation Detail for PRICKLE1


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Basic Information Top
Gene Symbol:PRICKLE1 ( EPM1B,FLJ31627,FLJ31937,MGC138902,MGC138903,RILP )
Gene Full Name: prickle homolog 1 (Drosophila)
Band: 12q12
Quick LinksEntrez ID:144165; OMIM: 608500; Uniprot ID:PRIC1_HUMAN; ENSEMBL ID: ENSG00000139174; HGNC ID: 17019
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus4 / 5640127
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult11 / 19391215
embryoid body4 / 7076156
blastocyst2 / 6231932
fetus25 / 56401244
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult57 / 193912129
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal19 / 33603075
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor25 / 26384594
glioma7 / 10688365
head and neck tumor2 / 13630214
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal114 / 336030733
ovarian tumor4 / 7668252
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain2 / 11009891
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye3 / 21105414
heart1 / 8962611
intestine0 / 2344720 
kidney1 / 2117774
larynx1 / 2414541
liver2 / 2077439
lung0 / 3369740 
lymph1 / 4427022
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate0 / 1893450 
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone2 / 7165527
bone marrow4 / 4880181
brain47 / 110098942
cervix0 / 481710 
connective tissue2 / 14925513
ear1 / 1621261
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye9 / 21105442
heart6 / 8962666
intestine1 / 2344724
kidney7 / 21177733
larynx0 / 241450 
liver0 / 2077430 
lung5 / 33697414
lymph1 / 4427022
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary4 / 10205139
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate3 / 18934515
salivary gland0 / 201550 
skin1 / 2105744
spleen3 / 5395255
stomach1 / 9661910
testis19 / 33044257
thymus1 / 8113112
thyroid2 / 4747342
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus12 / 23287851
vascular2 / 5178038
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P408285
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.22 ± 0.37
Basal Forebrain8.31 ± 0.21
Basal Part of Pons10.16 ± 0.14
Cerebellar Cortex9.07 ± 0.25
Cerebellar Nuclei9.09 ± 0.42
Claustrum9.95 ± 0.23
Epithalamus8.28 ± 0.99
Frontal Lobe9.57 ± 0.5
Globus Pallidus8.01 ± 0.76
Hypothalamus8.9 ± 0.42
Insula9.56 ± 0.28
Limbic Lobe9.59 ± 0.63
Mesencephalon9.07 ± 0.51
Myelencephalon9.3 ± 0.67
Occipital Lobe9.92 ± 0.39
Parietal Lobe9.75 ± 0.48
Pontine Tegmentum9.31 ± 0.47
Striatum8.4 ± 1.03
Subthalamus9.06 ± 0.29
Temporal Lobe9.63 ± 0.4
Thalamus9.99 ± 0.45
White Matter7.56 ± 0.72
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Prickle1CBCerebellum10.07
10.58
Prickle1CTXCerebral cortex100
100
Prickle1HIPHippocampal region49.54
80.98
Prickle1HPFHippocampal formation49.32
64.88
Prickle1HYHypothalamus13.03
10.28
Prickle1LSXLateral septal complex10.37
8.54
Prickle1MBMidbrain15.11
13.11
Prickle1MYMedulla20.92
21.22
Prickle1OLFOlfactory bulb58.22
50.24
Prickle1PPons15.6
14.61
Prickle1PALPallidum21.52
19.05
Prickle1RHPRetrohippocampal region48.11
43.64
Prickle1sAMYStriatum-like amygdalar nuclei33.5
26.99
Prickle1STRStriatum22.27
19.29
Prickle1STRdStriatum dorsal region23.56
21.41
Prickle1STRvStriatum ventral region19.54
14.9
Prickle1THThalamus72.24
73.22
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018