AutismKB 2.0

Annotation Detail for WDR66


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Basic Information Top
Gene Symbol:WDR66 ( FLJ39783,MGC33630 )
Gene Full Name: WD repeat domain 66
Band: 12q24.31
Quick LinksEntrez ID:144406; OMIM: NA; Uniprot ID:WDR66_HUMAN; ENSEMBL ID: ENSG00000158023; HGNC ID: 28506
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus4 / 5640127
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult23 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal51 / 336030715
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone2 / 7165527
bone marrow0 / 488010 
brain3 / 11009892
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye4 / 21105418
heart0 / 896260 
intestine5 / 23447221
kidney3 / 21177714
larynx0 / 241450 
liver0 / 2077430 
lung15 / 33697444
lymph0 / 442700 
lymph node1 / 9161010
mammary gland0 / 1532710 
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland1 / 1658560
placenta3 / 28082510
prostate0 / 1893450 
salivary gland0 / 201550 
skin3 / 21057414
spleen4 / 5395274
stomach0 / 966190 
testis15 / 33044245
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209334_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts3.8
Adipocyte2.95
AdrenalCortex3
Adrenalgland2.45
Amygdala3.15
Appendix2.95
AtrioventricularNode2.25
BDCA4+_DentriticCells4.4
Bonemarrow2.9
BronchialEpithelialCells2.95
CD105+_Endothelial3.65
CD14+_Monocytes3.2
CD19+_BCells(neg._sel.)3.25
CD33+_Myeloid3.85
CD34+3.9
CD4+_Tcells3.3
CD56+_NKCells3.55
CD71+_EarlyErythroid19.75
CD8+_Tcells2.9
CardiacMyocytes3.7
Caudatenucleus2.65
Cerebellum2.4
CerebellumPeduncles3.35
CiliaryGanglion2.1
CingulateCortex3
Colorectaladenocarcinoma3
DorsalRootGanglion2.35
FetalThyroid2.85
Fetalbrain3
Fetalliver2.55
Fetallung2.45
GlobusPallidus2.15
Heart3.75
Hypothalamus3.25
Kidney2.35
Leukemia_chronicMyelogenousK-5622.65
Leukemia_promyelocytic-HL-602.6
Leukemialymphoblastic(MOLT-4)2.35
Liver3.85
Lung3.3
Lymphnode2.6
Lymphoma_burkitts(Daudi)3.75
Lymphoma_burkitts(Raji)4.1
MedullaOblongata2.7
OccipitalLobe2.65
OlfactoryBulb2.35
Ovary1.95
Pancreas2.45
PancreaticIslet3.15
ParietalLobe3.1
Pituitary3.45
Placenta3.1
Pons2.8
PrefrontalCortex3.75
Prostate3.5
Salivarygland2.3
SkeletalMuscle3.3
Skin2.25
SmoothMuscle3.5
Spinalcord3.15
SubthalamicNucleus2.7
SuperiorCervicalGanglion3.3
TemporalLobe2.7
Testis2.6
TestisGermCell2.5
TestisIntersitial2.5
TestisLeydigCell2.9
TestisSeminiferousTubule2.55
Thalamus3
Thymus2.35
Thyroid3.75
Tongue3.2
Tonsil2.85
Trachea2.5
TrigeminalGanglion3.3
Uterus2.45
UterusCorpus2.65
WholeBlood3.3
Wholebrain2.6
colon3
pineal_day3.74
pineal_night3.64
retina3.625
small_intestine3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P179504
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.58 ± 0.78
Basal Forebrain3.46 ± 0.63
Basal Part of Pons2.88 ± 0.5
Cerebellar Cortex2.8 ± 0.5
Cerebellar Nuclei2.99 ± 0.54
Claustrum3.75 ± 0.94
Epithalamus5.63 ± 1.05
Frontal Lobe3.78 ± 0.74
Globus Pallidus2.55 ± 1.11
Hypothalamus3.88 ± 0.62
Insula4.11 ± 0.54
Limbic Lobe3.85 ± 0.69
Mesencephalon3.46 ± 0.8
Myelencephalon3.54 ± 0.86
Occipital Lobe2.87 ± 0.63
Parietal Lobe3.26 ± 0.79
Pontine Tegmentum3.58 ± 0.75
Striatum4.27 ± 0.89
Subthalamus3.27 ± 0.76
Temporal Lobe3.6 ± 0.69
Thalamus3.1 ± 0.67
White Matter1.65 ± 0.98
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Wdr66CBCerebellum1.23
2.22
Wdr66CTXCerebral cortex1.26
1.72
Wdr66HIPHippocampal region0.47
0.62
Wdr66HPFHippocampal formation0.52
0.58
Wdr66HYHypothalamus0.16
0.7
Wdr66LSXLateral septal complex0.03
0
Wdr66MBMidbrain0.37
0.51
Wdr66MYMedulla0.66
0.67
Wdr66OLFOlfactory bulb0.6
0.54
Wdr66PPons0.17
0.19
Wdr66PALPallidum0.07
0.05
Wdr66RHPRetrohippocampal region0.61
0.52
Wdr66sAMYStriatum-like amygdalar nuclei0
0
Wdr66STRStriatum0.14
0.2
Wdr66STRdStriatum dorsal region0.14
0.23
Wdr66STRvStriatum ventral region0.14
0.17
Wdr66THThalamus0.32
0.5
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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