AutismKB 2.0

Annotation Detail for CSNK1E


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Basic Information Top
Gene Symbol:CSNK1E ( HCKIE,MGC10398 )
Gene Full Name: casein kinase 1, epsilon
Band: 22q13.1
Quick LinksEntrez ID:1454; OMIM: 600863; Uniprot ID:KC1E_HUMAN; ENSEMBL ID: ENSG00000213923; HGNC ID: 2453
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst7 / 62319112
fetus66 / 564012117
neonate0 / 310970 
infant1 / 2362042
juvenile3 / 5555653
adult233 / 1939121120
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor8 / 9417884
cervical tumor6 / 34366174
chondrosarcoma8 / 8282396
colorectal tumor7 / 11424661
esophageal tumor1 / 1729057
gastrointestinal tumor13 / 119369108
germ cell tumor13 / 26384549
glioma27 / 106883252
head and neck tumor23 / 136302168
kidney tumor7 / 68959101
leukemia10 / 95842104
liver tumor6 / 9635962
lung tumor13 / 103127126
lymphoma4 / 7175555
non-neoplasia1 / 9725010
normal288 / 336030785
ovarian tumor6 / 7668278
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS46 / 125680366
prostate cancer5 / 10268048
retinoblastoma5 / 46356107
skin tumor36 / 124949288
soft tissue/muscle tissue tumor19 / 125191151
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites3 / 4001574
bladder2 / 2975767
blood9 / 12347872
bone5 / 7165569
bone marrow1 / 4880120
brain104 / 110098994
cervix19 / 48171394
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue21 / 21572297
esophagus1 / 2020949
eye21 / 21105499
heart6 / 8962666
intestine17 / 23447272
kidney12 / 21177756
larynx2 / 2414582
liver8 / 20774338
lung49 / 336974145
lymph3 / 4427067
lymph node7 / 9161076
mammary gland14 / 15327191
mouth15 / 67052223
muscle3 / 10771527
nerve6 / 15768380
ovary8 / 10205178
pancreas28 / 214812130
parathyroid5 / 20539243
pharynx4 / 4132896
pituitary gland5 / 16585301
placenta37 / 280825131
prostate14 / 18934573
salivary gland0 / 201550 
skin52 / 210574246
spleen3 / 5395255
stomach7 / 9661972
testis3 / 3304429
thymus0 / 811310 
thyroid4 / 4747384
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus29 / 232878124
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202332_at
Cell line Expression level Expression bar
721_B_lymphoblasts32.55
Adipocyte13.55
AdrenalCortex28.25
Adrenalgland15.9
Amygdala27.95
Appendix19.9
AtrioventricularNode13.75
BDCA4+_DentriticCells97.95
Bonemarrow11.15
BronchialEpithelialCells28.7
CD105+_Endothelial26.1
CD14+_Monocytes26.6
CD19+_BCells(neg._sel.)42.1
CD33+_Myeloid29.15
CD34+61.8
CD4+_Tcells29.7
CD56+_NKCells33.7
CD71+_EarlyErythroid18.7
CD8+_Tcells26.6
CardiacMyocytes41.45
Caudatenucleus22.3
Cerebellum18.7
CerebellumPeduncles53.75
CiliaryGanglion17.4
CingulateCortex42.95
Colorectaladenocarcinoma25.4
DorsalRootGanglion18.95
FetalThyroid24.65
Fetalbrain55.35
Fetalliver15.15
Fetallung21.7
GlobusPallidus28.9
Heart31.75
Hypothalamus29.55
Kidney12.1
Leukemia_chronicMyelogenousK-56217.75
Leukemia_promyelocytic-HL-6032
Leukemialymphoblastic(MOLT-4)20.05
Liver15.6
Lung44.75
Lymphnode15.85
Lymphoma_burkitts(Daudi)30.3
Lymphoma_burkitts(Raji)66.45
MedullaOblongata33.9
OccipitalLobe33.95
OlfactoryBulb20.4
Ovary19.35
Pancreas13.3
PancreaticIslet27.05
ParietalLobe28.7
Pituitary17.45
Placenta28.4
Pons33.2
PrefrontalCortex105.9
Prostate31.85
Salivarygland13.2
SkeletalMuscle24.25
Skin18.95
SmoothMuscle44.75
Spinalcord25.15
SubthalamicNucleus28.8
SuperiorCervicalGanglion25.25
TemporalLobe33.65
Testis17.35
TestisGermCell21.9
TestisIntersitial14.55
TestisLeydigCell23.5
TestisSeminiferousTubule21.9
Thalamus27.35
Thymus19.7
Thyroid28
Tongue22.95
Tonsil20.2
Trachea15.45
TrigeminalGanglion24.6
Uterus27.65
UterusCorpus22.5
WholeBlood11.25
Wholebrain36.85
colon29.45
pineal_day156.96
pineal_night184
retina72.15
small_intestine29.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P29263
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.92 ± 0.21
Basal Forebrain5.92 ± 0.35
Basal Part of Pons6.25 ± 0.42
Cerebellar Cortex6.31 ± 0.42
Cerebellar Nuclei5.51 ± 0.62
Claustrum5.95 ± 0.52
Epithalamus6.27 ± 0.38
Frontal Lobe6.09 ± 0.53
Globus Pallidus5.68 ± 0.31
Hypothalamus6.07 ± 0.5
Insula6.19 ± 0.49
Limbic Lobe5.99 ± 0.39
Mesencephalon5.76 ± 0.54
Myelencephalon6 ± 0.53
Occipital Lobe5.91 ± 0.33
Parietal Lobe5.99 ± 0.37
Pontine Tegmentum5.93 ± 0.42
Striatum5.49 ± 0.37
Subthalamus6.12 ± 0.38
Temporal Lobe6.13 ± 0.42
Thalamus6.12 ± 0.42
White Matter6.24 ± 0.39
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Csnk1eCBCerebellum12.2
15.19
Csnk1eCTXCerebral cortex100
100
Csnk1eHIPHippocampal region59.4
84.86
Csnk1eHPFHippocampal formation73.37
90.22
Csnk1eHYHypothalamus98.53
88.18
Csnk1eLSXLateral septal complex77.29
67.27
Csnk1eMBMidbrain67.95
71.29
Csnk1eMYMedulla34.6
50.62
Csnk1eOLFOlfactory bulb84.23
87.47
Csnk1ePPons56.58
75.38
Csnk1ePALPallidum65.1
68.85
Csnk1eRHPRetrohippocampal region100
100
Csnk1esAMYStriatum-like amygdalar nuclei76.12
64.47
Csnk1eSTRStriatum47.59
40.97
Csnk1eSTRdStriatum dorsal region36.99
32.4
Csnk1eSTRvStriatum ventral region51.97
42.17
Csnk1eTHThalamus95.48
96.87
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00065545 13 128 140 DVKPDNFLMGLGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018