AutismKB 2.0

Annotation Detail for NCAN


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Basic Information Top
Gene Symbol:NCAN ( CSPG3,FLJ44681 )
Gene Full Name: neurocan
Band: 19p12
Quick LinksEntrez ID:1463; OMIM: 600826; Uniprot ID:NCAN_HUMAN; ENSEMBL ID: ENSG00000130287; HGNC ID: 2465
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus31 / 56401254
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult17 / 19391218
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor6 / 26384522
glioma29 / 106883271
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal78 / 336030723
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain103 / 110098993
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth2 / 6705229
muscle1 / 1077159
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205143_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.9
Adipocyte4
AdrenalCortex4.3
Adrenalgland3.4
Amygdala442.75
Appendix6.25
AtrioventricularNode3.1
BDCA4+_DentriticCells4.45
Bonemarrow4.05
BronchialEpithelialCells3.9
CD105+_Endothelial4.15
CD14+_Monocytes4.2
CD19+_BCells(neg._sel.)4.3
CD33+_Myeloid5.25
CD34+5.85
CD4+_Tcells4.45
CD56+_NKCells4.8
CD71+_EarlyErythroid4.1
CD8+_Tcells3.9
CardiacMyocytes5.05
Caudatenucleus71.85
Cerebellum18.55
CerebellumPeduncles9.35
CiliaryGanglion2.85
CingulateCortex49.4
Colorectaladenocarcinoma4.05
DorsalRootGanglion3.15
FetalThyroid3.9
Fetalbrain605.55
Fetalliver3.5
Fetallung3.25
GlobusPallidus28.5
Heart5.2
Hypothalamus74.05
Kidney3.3
Leukemia_chronicMyelogenousK-5623.7
Leukemia_promyelocytic-HL-603.55
Leukemialymphoblastic(MOLT-4)3.25
Liver5.35
Lung4.35
Lymphnode3.4
Lymphoma_burkitts(Daudi)5.15
Lymphoma_burkitts(Raji)5.95
MedullaOblongata51.1
OccipitalLobe55.65
OlfactoryBulb3.2
Ovary2.8
Pancreas3.25
PancreaticIslet4.3
ParietalLobe43.25
Pituitary4.7
Placenta4.05
Pons26.05
PrefrontalCortex235.7
Prostate4.7
Salivarygland3.3
SkeletalMuscle4.8
Skin3.25
SmoothMuscle4.55
Spinalcord16.95
SubthalamicNucleus17.25
SuperiorCervicalGanglion4.75
TemporalLobe64.8
Testis3.55
TestisGermCell3.35
TestisIntersitial3.4
TestisLeydigCell4
TestisSeminiferousTubule3.45
Thalamus38.85
Thymus3.05
Thyroid5.05
Tongue4
Tonsil3.9
Trachea3.4
TrigeminalGanglion4.75
Uterus3.35
UterusCorpus3.65
WholeBlood4.35
Wholebrain83.15
colon4.05
pineal_day26.32
pineal_night22.58
retina13.575
small_intestine3.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11245_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.18 ± 0.31
Basal Forebrain8.03 ± 0.19
Basal Part of Pons7.26 ± 0.33
Cerebellar Cortex7.23 ± 0.31
Cerebellar Nuclei6.55 ± 0.43
Claustrum8.22 ± 0.34
Epithalamus7 ± 0.73
Frontal Lobe7.82 ± 0.51
Globus Pallidus7.35 ± 0.58
Hypothalamus7.59 ± 0.49
Insula7.93 ± 0.44
Limbic Lobe8.09 ± 0.5
Mesencephalon7.79 ± 0.59
Myelencephalon7.84 ± 0.73
Occipital Lobe7.95 ± 0.61
Parietal Lobe7.65 ± 0.51
Pontine Tegmentum8.07 ± 0.39
Striatum8.52 ± 0.39
Subthalamus6.87 ± 0.72
Temporal Lobe7.94 ± 0.54
Thalamus8.25 ± 0.51
White Matter7.44 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cspg3CBCerebellum8.04
7.84
Cspg3CTXCerebral cortex100
100
Cspg3HIPHippocampal region60.09
100
Cspg3HPFHippocampal formation69.78
95.54
Cspg3HYHypothalamus4.65
3.64
Cspg3LSXLateral septal complex11.75
9.63
Cspg3MBMidbrain7.17
7.49
Cspg3MYMedulla4.19
4.68
Cspg3OLFOlfactory bulb79.47
84.8
Cspg3PPons3.53
4.43
Cspg3PALPallidum7.83
7.19
Cspg3RHPRetrohippocampal region86.8
87.45
Cspg3sAMYStriatum-like amygdalar nuclei19.62
15.78
Cspg3STRStriatum42.05
32.75
Cspg3STRdStriatum dorsal region50.28
39.4
Cspg3STRvStriatum ventral region40.03
29.54
Cspg3THThalamus34.99
34.71
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00081256 12 1264 1275 WDRPQIVCTKPR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018