AutismKB 2.0

Annotation Detail for SIK1


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Basic Information Top
Gene Symbol:SIK1 ( MSK,SIK,SNF1LK )
Gene Full Name: salt-inducible kinase 1
Band: 21q22.3
Quick LinksEntrez ID:150094; OMIM: 605705; Uniprot ID:SIK1_HUMAN; ENSEMBL ID: ENSG00000142178; HGNC ID: 11142
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus13 / 56401223
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult81 / 193912141
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor3 / 9417831
cervical tumor4 / 34366116
chondrosarcoma9 / 82823108
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor7 / 11936958
germ cell tumor6 / 26384522
glioma11 / 106883102
head and neck tumor5 / 13630236
kidney tumor2 / 6895929
leukemia7 / 9584273
liver tumor3 / 9635931
lung tumor10 / 10312796
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal103 / 336030730
ovarian tumor0 / 766820 
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer7 / 10268068
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland3 / 3319790
ascites1 / 4001524
bladder2 / 2975767
blood3 / 12347824
bone4 / 7165555
bone marrow0 / 488010 
brain17 / 110098915
cervix4 / 4817183
connective tissue7 / 14925546
ear1 / 1621261
embryonic tissue3 / 21572213
esophagus1 / 2020949
eye8 / 21105437
heart0 / 896260 
intestine5 / 23447221
kidney12 / 21177756
larynx4 / 24145165
liver7 / 20774333
lung24 / 33697471
lymph0 / 442700 
lymph node6 / 9161065
mammary gland10 / 15327165
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas10 / 21481246
parathyroid2 / 2053997
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta7 / 28082524
prostate10 / 18934552
salivary gland0 / 201550 
skin5 / 21057423
spleen0 / 539520 
stomach6 / 9661962
testis6 / 33044218
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus12 / 23287851
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208078_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.4
Adipocyte7.45
AdrenalCortex249.05
Adrenalgland81.55
Amygdala9.65
Appendix18.75
AtrioventricularNode9.5
BDCA4+_DentriticCells619.1
Bonemarrow10.35
BronchialEpithelialCells150.45
CD105+_Endothelial9.9
CD14+_Monocytes23.65
CD19+_BCells(neg._sel.)90.7
CD33+_Myeloid351.85
CD34+26.15
CD4+_Tcells10.9
CD56+_NKCells77.25
CD71+_EarlyErythroid7.8
CD8+_Tcells9.9
CardiacMyocytes11.4
Caudatenucleus7.35
Cerebellum7.05
CerebellumPeduncles9.55
CiliaryGanglion7.05
CingulateCortex9.55
Colorectaladenocarcinoma10.1
DorsalRootGanglion7.9
FetalThyroid8.3
Fetalbrain9.2
Fetalliver8.35
Fetallung187.35
GlobusPallidus6.35
Heart11.45
Hypothalamus10.3
Kidney13.5
Leukemia_chronicMyelogenousK-5627.45
Leukemia_promyelocytic-HL-607.3
Leukemialymphoblastic(MOLT-4)6.05
Liver12.75
Lung294.8
Lymphnode10.5
Lymphoma_burkitts(Daudi)11.4
Lymphoma_burkitts(Raji)12.5
MedullaOblongata7.95
OccipitalLobe7.15
OlfactoryBulb103.05
Ovary38.95
Pancreas11.8
PancreaticIslet36.55
ParietalLobe9.4
Pituitary11.2
Placenta26.85
Pons8.85
PrefrontalCortex12.55
Prostate111.9
Salivarygland91.85
SkeletalMuscle11.25
Skin157.9
SmoothMuscle8.6
Spinalcord14.4
SubthalamicNucleus7.65
SuperiorCervicalGanglion11.6
TemporalLobe8.6
Testis8.55
TestisGermCell12.75
TestisIntersitial8.2
TestisLeydigCell9.6
TestisSeminiferousTubule7.65
Thalamus7.95
Thymus7.3
Thyroid28.5
Tongue24.95
Tonsil9.35
Trachea88.5
TrigeminalGanglion12
Uterus15.45
UterusCorpus8.45
WholeBlood8.75
Wholebrain13.3
colon16.1
pineal_day450.98
pineal_night619.9
retina219.7
small_intestine66.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P237231
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala11.57 ± 0.59
Basal Forebrain11.3 ± 0.21
Basal Part of Pons11.55 ± 0.34
Cerebellar Cortex11.12 ± 0.28
Cerebellar Nuclei11.57 ± 0.31
Claustrum11.55 ± 0.36
Epithalamus11.14 ± 0.29
Frontal Lobe11.52 ± 0.44
Globus Pallidus11.82 ± 0.22
Hypothalamus11.31 ± 0.51
Insula11.45 ± 0.49
Limbic Lobe11.5 ± 0.41
Mesencephalon11.55 ± 0.4
Myelencephalon11.46 ± 0.41
Occipital Lobe11.4 ± 0.37
Parietal Lobe11.42 ± 0.36
Pontine Tegmentum11.35 ± 0.34
Striatum11.66 ± 0.45
Subthalamus11.36 ± 0.23
Temporal Lobe11.42 ± 0.45
Thalamus11.49 ± 0.39
White Matter11.81 ± 0.44
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Snf1lkCBCerebellum21.66
25.59
Snf1lkCTXCerebral cortex83.15
64.66
Snf1lkHIPHippocampal region41.39
53.86
Snf1lkHPFHippocampal formation50.2
54.29
Snf1lkHYHypothalamus32.89
28.13
Snf1lkLSXLateral septal complex74.2
58.69
Snf1lkMBMidbrain31.64
27.96
Snf1lkMYMedulla26.77
27.51
Snf1lkOLFOlfactory bulb67.43
59.79
Snf1lkPPons29.19
31.72
Snf1lkPALPallidum36.08
33.49
Snf1lkRHPRetrohippocampal region68.58
56.96
Snf1lksAMYStriatum-like amygdalar nuclei52.82
39.52
Snf1lkSTRStriatum56.44
42.07
Snf1lkSTRdStriatum dorsal region53.98
40.38
Snf1lkSTRvStriatum ventral region60.19
42.93
Snf1lkTHThalamus37.93
32.87
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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