AutismKB 2.0

Annotation Detail for CTNND2


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Basic Information Top
Gene Symbol:CTNND2 ( GT24,NPRAP )
Gene Full Name: catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
Band: 5p15.2
Quick LinksEntrez ID:1501; OMIM: 604275; Uniprot ID:CTND2_HUMAN; ENSEMBL ID: ENSG00000169862; HGNC ID: 2516
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst2 / 6231932
fetus36 / 56401263
neonate0 / 310970 
infant2 / 2362084
juvenile1 / 5555617
adult191 / 193912198
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor8 / 26384530
glioma11 / 106883102
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal304 / 336030790
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer0 / 1026800 
retinoblastoma3 / 4635664
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor35 / 125191279
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain295 / 1100989267
cervix0 / 481710 
connective tissue35 / 149255234
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye10 / 21105447
heart0 / 896260 
intestine0 / 2344720 
kidney2 / 2117779
larynx1 / 2414541
liver0 / 2077430 
lung6 / 33697417
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach0 / 966190 
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209618_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.9
Adipocyte3.9
AdrenalCortex4.25
Adrenalgland3.4
Amygdala276.3
Appendix4.5
AtrioventricularNode3.1
BDCA4+_DentriticCells4.3
Bonemarrow3.95
BronchialEpithelialCells3.9
CD105+_Endothelial4
CD14+_Monocytes4.2
CD19+_BCells(neg._sel.)4.2
CD33+_Myeloid5.05
CD34+4.95
CD4+_Tcells4.25
CD56+_NKCells4.7
CD71+_EarlyErythroid3.7
CD8+_Tcells3.8
CardiacMyocytes5.2
Caudatenucleus39.65
Cerebellum55.05
CerebellumPeduncles14.15
CiliaryGanglion2.9
CingulateCortex38.35
Colorectaladenocarcinoma3.95
DorsalRootGanglion3.15
FetalThyroid3.85
Fetalbrain70.8
Fetalliver3.45
Fetallung3.25
GlobusPallidus46.1
Heart5.15
Hypothalamus81.65
Kidney3.3
Leukemia_chronicMyelogenousK-5623.55
Leukemia_promyelocytic-HL-603.5
Leukemialymphoblastic(MOLT-4)3.15
Liver5.35
Lung4.35
Lymphnode3.4
Lymphoma_burkitts(Daudi)5.15
Lymphoma_burkitts(Raji)5.65
MedullaOblongata46.6
OccipitalLobe77.4
OlfactoryBulb4
Ovary2.65
Pancreas3.25
PancreaticIslet4.3
ParietalLobe32.2
Pituitary4.75
Placenta4.05
Pons13.05
PrefrontalCortex94.85
Prostate4.6
Salivarygland3.2
SkeletalMuscle4.8
Skin3.1
SmoothMuscle4.45
Spinalcord95.25
SubthalamicNucleus27.75
SuperiorCervicalGanglion5.35
TemporalLobe20.15
Testis3.4
TestisGermCell3.25
TestisIntersitial3.3
TestisLeydigCell3.95
TestisSeminiferousTubule3.4
Thalamus38.45
Thymus3.1
Thyroid4.95
Tongue3.95
Tonsil3.85
Trachea3.3
TrigeminalGanglion4
Uterus3.2
UterusCorpus3.6
WholeBlood4.3
Wholebrain93.65
colon4
pineal_day27.42
pineal_night14.2
retina20.9
small_intestine3.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_215_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.18 ± 0.33
Basal Forebrain8.81 ± 0.3
Basal Part of Pons8.42 ± 0.16
Cerebellar Cortex8.44 ± 0.24
Cerebellar Nuclei8.36 ± 0.29
Claustrum9.19 ± 0.63
Epithalamus8.86 ± 0.43
Frontal Lobe8.75 ± 0.4
Globus Pallidus9.35 ± 0.2
Hypothalamus8.46 ± 0.25
Insula8.85 ± 0.37
Limbic Lobe9.08 ± 0.47
Mesencephalon8.88 ± 0.46
Myelencephalon8.96 ± 0.43
Occipital Lobe9.03 ± 0.38
Parietal Lobe8.85 ± 0.46
Pontine Tegmentum8.78 ± 0.26
Striatum8.87 ± 0.44
Subthalamus8.21 ± 0.26
Temporal Lobe8.92 ± 0.35
Thalamus9.02 ± 0.29
White Matter8.46 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ctnnd2CBCerebellum15.65
19.5
Ctnnd2CTXCerebral cortex77.82
69.38
Ctnnd2HIPHippocampal region27.75
38.15
Ctnnd2HPFHippocampal formation43.13
50.47
Ctnnd2HYHypothalamus10.72
9.37
Ctnnd2LSXLateral septal complex3.3
2.77
Ctnnd2MBMidbrain12.28
12.85
Ctnnd2MYMedulla14.95
17.29
Ctnnd2OLFOlfactory bulb51.66
44.73
Ctnnd2PPons7.8
8.83
Ctnnd2PALPallidum23.72
25.51
Ctnnd2RHPRetrohippocampal region69.43
68.53
Ctnnd2sAMYStriatum-like amygdalar nuclei24.06
20.02
Ctnnd2STRStriatum34.36
26.5
Ctnnd2STRdStriatum dorsal region44.09
34.44
Ctnnd2STRvStriatum ventral region20.4
14.19
Ctnnd2THThalamus35.09
30.67
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CTND2_HUMAN_1008 13 1008 1020 AASQVLNSMWQYR PRIDE
CTND2_HUMAN_265 15 265 279 GGSPLAAPQGGSPTK PRIDE
CTND2_HUMAN_283 14 283 296 GGSAPEGATYAAPR PRIDE
CTND2_HUMAN_297 10 297 306 GSSPKQSPSR PRIDE
CTND2_HUMAN_397 15 397 411 ASYSSQHGHLGPELR PRIDE
CTND2_HUMAN_472 17 472 488 TGSQHGPQNAAAATFQR PRIDE
CTND2_HUMAN_505 14 505 518 QLQYCPSVESPYSK PRIDE
CTND2_HUMAN_519 13 519 531 SGPALPPEGTLAR PRIDE
CTND2_HUMAN_941 13 941 953 LPGGNNSNNTASK PRIDE
PAp00065787 25 735 759 ECDGLTDALLYVIQSALGSSEIDSK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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