AutismKB 2.0

Annotation Detail for CTRL


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Basic Information Top
Gene Symbol:CTRL ( CTRL1,MGC70821 )
Gene Full Name: chymotrypsin-like
Band: 16q22.1
Quick LinksEntrez ID:1506; OMIM: 118888; Uniprot ID:CTRL_HUMAN; ENSEMBL ID: ENSG00000141086; HGNC ID: 2524
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult43 / 193912122
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor0 / 2638450 
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal69 / 336030720
ovarian tumor0 / 766820 
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder9 / 29757302
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain3 / 11009892
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung2 / 3369745
lymph0 / 442700 
lymph node7 / 9161076
mammary gland0 / 1532710 
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas36 / 214812167
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214377_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.85
Adipocyte4
AdrenalCortex4.25
Adrenalgland3.35
Amygdala4.2
Appendix4
AtrioventricularNode3.05
BDCA4+_DentriticCells4.45
Bonemarrow3.95
BronchialEpithelialCells3.75
CD105+_Endothelial4.05
CD14+_Monocytes4.3
CD19+_BCells(neg._sel.)4.35
CD33+_Myeloid5.15
CD34+4.6
CD4+_Tcells5.65
CD56+_NKCells4.8
CD71+_EarlyErythroid3.75
CD8+_Tcells5.2
CardiacMyocytes5.1
Caudatenucleus3.6
Cerebellum3.2
CerebellumPeduncles6.75
CiliaryGanglion2.8
CingulateCortex5.05
Colorectaladenocarcinoma4
DorsalRootGanglion3.05
FetalThyroid3.85
Fetalbrain3.95
Fetalliver3.55
Fetallung3.3
GlobusPallidus2.95
Heart5.05
Hypothalamus4.4
Kidney3.3
Leukemia_chronicMyelogenousK-5623.6
Leukemia_promyelocytic-HL-604.35
Leukemialymphoblastic(MOLT-4)3.1
Liver5.25
Lung4.45
Lymphnode5
Lymphoma_burkitts(Daudi)5.1
Lymphoma_burkitts(Raji)6.1
MedullaOblongata3.7
OccipitalLobe3.6
OlfactoryBulb3.15
Ovary2.6
Pancreas1938.1
PancreaticIslet496.65
ParietalLobe4.2
Pituitary4.65
Placenta4.1
Pons5
PrefrontalCortex5
Prostate4.7
Salivarygland3.2
SkeletalMuscle4.75
Skin3.1
SmoothMuscle4.5
Spinalcord4.25
SubthalamicNucleus3.65
SuperiorCervicalGanglion4.5
TemporalLobe3.65
Testis3.4
TestisGermCell4.1
TestisIntersitial3.35
TestisLeydigCell3.95
TestisSeminiferousTubule3.45
Thalamus4.95
Thymus3.15
Thyroid4.95
Tongue3.9
Tonsil3.95
Trachea3.25
TrigeminalGanglion3.95
Uterus3.15
UterusCorpus3.55
WholeBlood4.45
Wholebrain3.4
colon4.2
pineal_day4.9
pineal_night4.76
retina4.775
small_intestine3.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P90900
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.18 ± 0.95
Basal Forebrain2.52 ± 0.36
Basal Part of Pons2.58 ± 0.34
Cerebellar Cortex3.36 ± 0.51
Cerebellar Nuclei3.08 ± 0.71
Claustrum3.31 ± 0.63
Epithalamus2.97 ± 0.65
Frontal Lobe2.8 ± 0.71
Globus Pallidus2.67 ± 0.64
Hypothalamus2.77 ± 0.67
Insula2.58 ± 0.67
Limbic Lobe2.77 ± 0.62
Mesencephalon3.02 ± 0.68
Myelencephalon2.89 ± 0.64
Occipital Lobe2.96 ± 0.7
Parietal Lobe2.74 ± 0.62
Pontine Tegmentum2.92 ± 0.7
Striatum3.16 ± 0.81
Subthalamus3.11 ± 0.52
Temporal Lobe2.76 ± 0.67
Thalamus2.81 ± 0.64
White Matter3.38 ± 0.75
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
CtrlCBCerebellum1.03
1.31
CtrlCTXCerebral cortex1.07
1.07
CtrlHIPHippocampal region0.64
0.75
CtrlHPFHippocampal formation0.59
0.67
CtrlHYHypothalamus0.25
0.18
CtrlLSXLateral septal complex0.24
0.16
CtrlMBMidbrain0.53
0.55
CtrlMYMedulla1.37
1.03
CtrlOLFOlfactory bulb0.86
0.74
CtrlPPons0.7
0.76
CtrlPALPallidum0.26
0.3
CtrlRHPRetrohippocampal region0.47
0.6
CtrlsAMYStriatum-like amygdalar nuclei1.27
1.22
CtrlSTRStriatum1.05
0.98
CtrlSTRdStriatum dorsal region1.25
1.19
CtrlSTRvStriatum ventral region0.5
0.53
CtrlTHThalamus0.59
0.6
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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