AutismKB 2.0

Annotation Detail for KLHL23


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Basic Information Top
Gene Symbol:KLHL23 ( DITHP,FLJ37812,MGC22679,MGC2610 )
Gene Full Name: kelch-like 23 (Drosophila)
Band: 2q31.1
Quick LinksEntrez ID:151230; OMIM: NA; Uniprot ID:KLH23_HUMAN; ENSEMBL ID: ENSG00000213160; HGNC ID: 27506
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213610_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts15.7
Adipocyte16.8
AdrenalCortex36.05
Adrenalgland17.5
Amygdala23.65
Appendix42.85
AtrioventricularNode35.45
BDCA4+_DentriticCells13.05
Bonemarrow25
BronchialEpithelialCells14.5
CD105+_Endothelial19.65
CD14+_Monocytes20.8
CD19+_BCells(neg._sel.)18.25
CD33+_Myeloid18.75
CD34+24
CD4+_Tcells14.65
CD56+_NKCells15.55
CD71+_EarlyErythroid18.4
CD8+_Tcells12.75
CardiacMyocytes44.7
Caudatenucleus15.95
Cerebellum14.6
CerebellumPeduncles26.9
CiliaryGanglion34.55
CingulateCortex22.05
Colorectaladenocarcinoma19.7
DorsalRootGanglion26.75
FetalThyroid22.45
Fetalbrain44.9
Fetalliver16.75
Fetallung11.6
GlobusPallidus19.2
Heart38.45
Hypothalamus16.65
Kidney19.45
Leukemia_chronicMyelogenousK-56217.9
Leukemia_promyelocytic-HL-6016.5
Leukemialymphoblastic(MOLT-4)19.75
Liver32.85
Lung18.3
Lymphnode13.25
Lymphoma_burkitts(Daudi)25.4
Lymphoma_burkitts(Raji)34.5
MedullaOblongata19.65
OccipitalLobe16.35
OlfactoryBulb12.9
Ovary29.7
Pancreas18.4
PancreaticIslet19.8
ParietalLobe24.3
Pituitary20.45
Placenta15.2
Pons20.4
PrefrontalCortex22.25
Prostate21.4
Salivarygland17
SkeletalMuscle45.9
Skin27.4
SmoothMuscle18.25
Spinalcord18.75
SubthalamicNucleus20.65
SuperiorCervicalGanglion49.35
TemporalLobe19.25
Testis14.45
TestisGermCell15.75
TestisIntersitial18.15
TestisLeydigCell22.45
TestisSeminiferousTubule15.55
Thalamus19.55
Thymus11.6
Thyroid20.65
Tongue29.35
Tonsil19.45
Trachea13.8
TrigeminalGanglion41.45
Uterus35
UterusCorpus24.7
WholeBlood17.25
Wholebrain11.6
colon91.35
pineal_day22.16
pineal_night22.54
retina21.35
small_intestine56.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P165414
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.4 ± 0.2
Basal Forebrain6.17 ± 0.19
Basal Part of Pons5.88 ± 0.46
Cerebellar Cortex6.07 ± 0.32
Cerebellar Nuclei5.76 ± 0.43
Claustrum6.23 ± 0.36
Epithalamus5.74 ± 0.38
Frontal Lobe6.03 ± 0.34
Globus Pallidus6.06 ± 0.31
Hypothalamus6.02 ± 0.27
Insula6 ± 0.24
Limbic Lobe6.29 ± 0.3
Mesencephalon6.13 ± 0.34
Myelencephalon6 ± 0.41
Occipital Lobe6.25 ± 0.38
Parietal Lobe6.03 ± 0.36
Pontine Tegmentum6.18 ± 0.28
Striatum6.21 ± 0.27
Subthalamus6.06 ± 0.16
Temporal Lobe6.16 ± 0.3
Thalamus5.95 ± 0.36
White Matter4.7 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Klhl23CBCerebellum3.44
3.98
Klhl23CTXCerebral cortex17.89
14.7
Klhl23HIPHippocampal region18.54
19.32
Klhl23HPFHippocampal formation13.7
13.2
Klhl23HYHypothalamus0.1
0.09
Klhl23LSXLateral septal complex0.94
0.76
Klhl23MBMidbrain1.83
2
Klhl23MYMedulla1.06
1.09
Klhl23OLFOlfactory bulb15.03
13.67
Klhl23PPons1.03
0.99
Klhl23PALPallidum0.57
0.62
Klhl23RHPRetrohippocampal region6.98
5.73
Klhl23sAMYStriatum-like amygdalar nuclei1.54
1.08
Klhl23STRStriatum1.42
1.06
Klhl23STRdStriatum dorsal region0.9
0.69
Klhl23STRvStriatum ventral region3.57
2.41
Klhl23THThalamus1.59
1.79
Peptide Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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