AutismKB 2.0

Annotation Detail for SPICE1


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Basic Information Top
Gene Symbol:SPICE1 ( CCDC52,FLJ26064,FLJ44949,SPICE )
Gene Full Name: spindle and centriole associated protein 1
Band: 3q13.2
Quick LinksEntrez ID:152185; OMIM: 613447; Uniprot ID:SPICE_HUMAN; ENSEMBL ID: ENSG00000163611; HGNC ID: 25083
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus13 / 56401223
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult27 / 193912113
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor5 / 11936941
germ cell tumor7 / 26384526
glioma2 / 10688318
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia4 / 9584241
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal51 / 336030715
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone1 / 7165513
bone marrow1 / 4880120
brain14 / 110098912
cervix0 / 481710 
connective tissue1 / 1492556
ear1 / 1621261
embryonic tissue6 / 21572227
esophagus1 / 2020949
eye5 / 21105423
heart1 / 8962611
intestine6 / 23447225
kidney8 / 21177737
larynx0 / 241450 
liver3 / 20774314
lung2 / 3369745
lymph1 / 4427022
lymph node5 / 9161054
mammary gland5 / 15327132
mouth3 / 6705244
muscle0 / 1077150 
nerve0 / 157680 
ovary3 / 10205129
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate3 / 18934515
salivary gland1 / 2015549
skin1 / 2105744
spleen1 / 5395218
stomach6 / 9661962
testis6 / 33044218
thymus8 / 8113198
thyroid0 / 474730 
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 215094_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.75
Adipocyte5
AdrenalCortex7.25
Adrenalgland4.75
Amygdala5.25
Appendix7.9
AtrioventricularNode6
BDCA4+_DentriticCells5.65
Bonemarrow6.05
BronchialEpithelialCells5.05
CD105+_Endothelial5.15
CD14+_Monocytes5.55
CD19+_BCells(neg._sel.)5.2
CD33+_Myeloid6.2
CD34+6.5
CD4+_Tcells5.25
CD56+_NKCells5.95
CD71+_EarlyErythroid5
CD8+_Tcells4.75
CardiacMyocytes7.65
Caudatenucleus4.6
Cerebellum4.25
CerebellumPeduncles6.45
CiliaryGanglion5.2
CingulateCortex5.6
Colorectaladenocarcinoma5.15
DorsalRootGanglion5.1
FetalThyroid5.2
Fetalbrain4.95
Fetalliver4.55
Fetallung4.15
GlobusPallidus4.4
Heart9.45
Hypothalamus5.5
Kidney4.55
Leukemia_chronicMyelogenousK-5624.6
Leukemia_promyelocytic-HL-604.6
Leukemialymphoblastic(MOLT-4)3.95
Liver8.1
Lung5.7
Lymphnode4.3
Lymphoma_burkitts(Daudi)7.05
Lymphoma_burkitts(Raji)8.65
MedullaOblongata4.7
OccipitalLobe4.55
OlfactoryBulb4.1
Ovary4.05
Pancreas4.5
PancreaticIslet5.6
ParietalLobe6.05
Pituitary5.95
Placenta4.95
Pons5.35
PrefrontalCortex6.2
Prostate5.85
Salivarygland4.5
SkeletalMuscle7.95
Skin4.9
SmoothMuscle5.8
Spinalcord5.45
SubthalamicNucleus5.2
SuperiorCervicalGanglion9.95
TemporalLobe4.95
Testis4.35
TestisGermCell4.1
TestisIntersitial4.4
TestisLeydigCell5.65
TestisSeminiferousTubule4.45
Thalamus5.5
Thymus3.75
Thyroid6.2
Tongue5.4
Tonsil5.2
Trachea4.25
TrigeminalGanglion7.75
Uterus4.05
UterusCorpus5.65
WholeBlood5.7
Wholebrain4.15
colon5.15
pineal_day6.24
pineal_night6.18
retina6.2
small_intestine4.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P119567
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.43 ± 0.69
Basal Forebrain3.06 ± 0.48
Basal Part of Pons2.83 ± 0.33
Cerebellar Cortex3.45 ± 0.53
Cerebellar Nuclei3.24 ± 0.64
Claustrum3.59 ± 0.62
Epithalamus4.17 ± 0.67
Frontal Lobe3.21 ± 0.63
Globus Pallidus2.9 ± 0.88
Hypothalamus3.46 ± 0.76
Insula3.28 ± 0.46
Limbic Lobe3.26 ± 0.58
Mesencephalon3.34 ± 0.75
Myelencephalon3.25 ± 0.66
Occipital Lobe3.1 ± 0.69
Parietal Lobe3.13 ± 0.66
Pontine Tegmentum3.25 ± 0.49
Striatum3.23 ± 0.56
Subthalamus2.98 ± 0.69
Temporal Lobe3.24 ± 0.63
Thalamus2.98 ± 0.56
White Matter3.35 ± 0.25
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ccdc52CBCerebellum2.13
2.85
Ccdc52CTXCerebral cortex1.32
1.2
Ccdc52HIPHippocampal region1.29
1.59
Ccdc52HPFHippocampal formation0.93
1.22
Ccdc52HYHypothalamus0.1
0.08
Ccdc52LSXLateral septal complex0.03
0
Ccdc52MBMidbrain0.62
0.86
Ccdc52MYMedulla2.91
3.22
Ccdc52OLFOlfactory bulb1.84
2.97
Ccdc52PPons0.92
1.47
Ccdc52PALPallidum0.26
0.19
Ccdc52RHPRetrohippocampal region0.26
0.31
Ccdc52sAMYStriatum-like amygdalar nuclei1.95
1.41
Ccdc52STRStriatum0.55
0.63
Ccdc52STRdStriatum dorsal region0.55
0.81
Ccdc52STRvStriatum ventral region0.41
0.27
Ccdc52THThalamus2.5
3.81
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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