AutismKB 2.0

Annotation Detail for CTSZ


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Basic Information Top
Gene Symbol:CTSZ ( CTSX,FLJ17088 )
Gene Full Name: cathepsin Z
Band: 20q13.32
Quick LinksEntrez ID:1522; OMIM: 603169; Uniprot ID:CATZ_HUMAN; ENSEMBL ID: ENSG00000101160; HGNC ID: 2547
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus21 / 56401237
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult196 / 1939121101
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor10 / 94178106
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor30 / 114246262
esophageal tumor0 / 172900 
gastrointestinal tumor40 / 119369335
germ cell tumor3 / 26384511
glioma5 / 10688346
head and neck tumor6 / 13630244
kidney tumor0 / 689590 
leukemia8 / 9584283
liver tumor3 / 9635931
lung tumor12 / 103127116
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal110 / 336030732
ovarian tumor12 / 76682156
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor15 / 90257166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder1 / 2975733
blood3 / 12347824
bone2 / 7165527
bone marrow0 / 488010 
brain11 / 11009899
cervix5 / 48171103
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye5 / 21105423
heart4 / 8962644
intestine42 / 234472179
kidney9 / 21177742
larynx2 / 2414582
liver3 / 20774314
lung33 / 33697497
lymph0 / 442700 
lymph node10 / 91610109
mammary gland23 / 153271150
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary12 / 102051117
pancreas11 / 21481251
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta14 / 28082549
prostate4 / 18934521
salivary gland0 / 201550 
skin9 / 21057442
spleen2 / 5395237
stomach39 / 96619403
testis2 / 3304426
thymus1 / 8113112
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus16 / 23287868
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210042_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.6
Adipocyte7.5
AdrenalCortex8.35
Adrenalgland6.35
Amygdala7.3
Appendix7.8
AtrioventricularNode6.4
BDCA4+_DentriticCells197.75
Bonemarrow7.55
BronchialEpithelialCells18.05
CD105+_Endothelial14.25
CD14+_Monocytes228.95
CD19+_BCells(neg._sel.)38.7
CD33+_Myeloid206.95
CD34+9.45
CD4+_Tcells7.2
CD56+_NKCells13.15
CD71+_EarlyErythroid34
CD8+_Tcells6.15
CardiacMyocytes10.25
Caudatenucleus6.55
Cerebellum6.05
CerebellumPeduncles8.55
CiliaryGanglion5.5
CingulateCortex7.3
Colorectaladenocarcinoma15.95
DorsalRootGanglion7.05
FetalThyroid78.35
Fetalbrain7.2
Fetalliver6.55
Fetallung8.3
GlobusPallidus5.6
Heart10.3
Hypothalamus8.7
Kidney6.25
Leukemia_chronicMyelogenousK-5626.65
Leukemia_promyelocytic-HL-606.75
Leukemialymphoblastic(MOLT-4)5.3
Liver10.35
Lung153.95
Lymphnode25.1
Lymphoma_burkitts(Daudi)9.7
Lymphoma_burkitts(Raji)16.45
MedullaOblongata6.4
OccipitalLobe6.4
OlfactoryBulb6.1
Ovary5.1
Pancreas6.2
PancreaticIslet14.45
ParietalLobe8.05
Pituitary13.9
Placenta9.35
Pons7.2
PrefrontalCortex9.25
Prostate22.55
Salivarygland5.75
SkeletalMuscle9.95
Skin6.15
SmoothMuscle8.35
Spinalcord7.95
SubthalamicNucleus6.85
SuperiorCervicalGanglion8.85
TemporalLobe7.1
Testis5.75
TestisGermCell6.1
TestisIntersitial5.9
TestisLeydigCell7.45
TestisSeminiferousTubule5.85
Thalamus7.7
Thymus5.65
Thyroid12.85
Tongue7.65
Tonsil7.4
Trachea6.4
TrigeminalGanglion7.8
Uterus6.05
UterusCorpus7.1
WholeBlood90.35
Wholebrain5.95
colon7.65
pineal_day8.38
pineal_night8.52
retina18.175
small_intestine9.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8503_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.07 ± 0.64
Basal Forebrain4.5 ± 0.35
Basal Part of Pons5.21 ± 0.4
Cerebellar Cortex4.99 ± 0.37
Cerebellar Nuclei5.11 ± 0.64
Claustrum3.76 ± 0.92
Epithalamus5.19 ± 0.36
Frontal Lobe4.75 ± 0.72
Globus Pallidus5.03 ± 0.6
Hypothalamus5.01 ± 0.87
Insula4.42 ± 0.52
Limbic Lobe4.02 ± 0.72
Mesencephalon4.61 ± 0.52
Myelencephalon4.46 ± 0.63
Occipital Lobe4.52 ± 0.57
Parietal Lobe4.63 ± 0.7
Pontine Tegmentum4.4 ± 0.74
Striatum4.2 ± 0.59
Subthalamus4.24 ± 0.37
Temporal Lobe4.04 ± 0.52
Thalamus4.64 ± 0.6
White Matter4.55 ± 0.54
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
CtszCBCerebellum13.89
18.45
CtszCTXCerebral cortex16.36
12.66
CtszHIPHippocampal region11.54
13.82
CtszHPFHippocampal formation10.59
11.3
CtszHYHypothalamus6.46
8.6
CtszLSXLateral septal complex10.45
9.26
CtszMBMidbrain6.11
7.28
CtszMYMedulla13.6
21.44
CtszOLFOlfactory bulb13.35
12.96
CtszPPons6.47
9.4
CtszPALPallidum6.8
6.49
CtszRHPRetrohippocampal region9.17
7.87
CtszsAMYStriatum-like amygdalar nuclei8.29
7.14
CtszSTRStriatum14.51
11.42
CtszSTRdStriatum dorsal region16.66
13.06
CtszSTRvStriatum ventral region11.43
8.03
CtszTHThalamus3.37
4.4
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CATZ_HUMAN_0 0 0 0 NQHIPQYCGSCWAHASTSAMADR PRIDE
CATZ_HUMAN_0 0 0 0 NSWGEPWGER PRIDE
CATZ_HUMAN_0 0 0 0 NVDGVNYASITR PRIDE
CATZ_HUMAN_0 0 0 0 YNLAIEEHCTFGDPIV PRIDE
CATZ_HUMAN_189 10 189 198 VGDYGSLSGR PRIDE
CATZ_HUMAN_189 12 189 200 VGDYGSLSGREK PRIDE
CATZ_HUMAN_260 10 260 269 NSWGEPWGER PRIDE
CATZ_HUMAN_260 14 260 273 NSWGEPWGERGWLR PRIDE
CATZ_HUMAN_287 16 287 302 YNLAIEEHCTFGDPIV PRIDE
CATZ_HUMAN_69 12 69 80 NVDGVNYASITR PRIDE
PAp00009012 16 288 303 YNLAIEEHCTFGDPIV Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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