AutismKB 2.0

Annotation Detail for FGD5


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FGD5 ( ZFYVE23 )
Gene Full Name: FYVE, RhoGEF and PH domain containing 5
Band: 3p25.1
Quick LinksEntrez ID:152273; OMIM: NA; Uniprot ID:FGD5_HUMAN; ENSEMBL ID: ENSG00000154783; HGNC ID: 19117
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus28 / 56401249
neonate8 / 31097257
infant0 / 236200 
juvenile0 / 555560 
adult35 / 193912118
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor1 / 2638453
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal94 / 336030727
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain10 / 11009899
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye3 / 21105414
heart7 / 8962678
intestine4 / 23447217
kidney10 / 21177747
larynx0 / 241450 
liver3 / 20774314
lung9 / 33697426
lymph0 / 442700 
lymph node0 / 916100 
mammary gland5 / 15327132
mouth0 / 670520 
muscle1 / 1077159
nerve1 / 1576863
ovary2 / 10205119
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate0 / 1893450 
salivary gland0 / 201550 
skin2 / 2105749
spleen5 / 5395292
stomach0 / 966190 
testis5 / 33044215
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord14 / 136801023
uterus1 / 2328784
vascular4 / 5178077
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P258151
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.91 ± 0.31
Basal Forebrain4.64 ± 0.28
Basal Part of Pons4.34 ± 0.38
Cerebellar Cortex4.28 ± 0.45
Cerebellar Nuclei5.73 ± 0.6
Claustrum4.73 ± 0.51
Epithalamus3.94 ± 0.79
Frontal Lobe4.81 ± 0.53
Globus Pallidus5.21 ± 0.44
Hypothalamus4.78 ± 0.36
Insula4.79 ± 0.37
Limbic Lobe4.61 ± 0.6
Mesencephalon5.01 ± 0.66
Myelencephalon4.91 ± 0.56
Occipital Lobe5.34 ± 0.59
Parietal Lobe5.05 ± 0.46
Pontine Tegmentum4.85 ± 0.56
Striatum5.22 ± 0.42
Subthalamus4.71 ± 0.48
Temporal Lobe4.68 ± 0.53
Thalamus4.99 ± 0.5
White Matter4.47 ± 0.89
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Fgd5CBCerebellum1.6
2.21
Fgd5CTXCerebral cortex0.88
0.89
Fgd5HIPHippocampal region0.9
1.03
Fgd5HPFHippocampal formation1.38
1.34
Fgd5HYHypothalamus1.04
1.15
Fgd5LSXLateral septal complex9.77
6.91
Fgd5MBMidbrain0.78
1.05
Fgd5MYMedulla1.24
1.63
Fgd5OLFOlfactory bulb1.46
1.38
Fgd5PPons0.94
1.04
Fgd5PALPallidum0.69
0.74
Fgd5RHPRetrohippocampal region2.36
1.91
Fgd5sAMYStriatum-like amygdalar nuclei0.45
0.65
Fgd5STRStriatum1.13
0.92
Fgd5STRdStriatum dorsal region0.51
0.48
Fgd5STRvStriatum ventral region0.96
0.84
Fgd5THThalamus2.62
2.86
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018