AutismKB 2.0

Annotation Detail for KLB


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Basic Information Top
Gene Symbol:KLB ( BKL,MGC142213 )
Gene Full Name: klotho beta
Band: 4p14
Quick LinksEntrez ID:152831; OMIM: 611135; Uniprot ID:KLOTB_HUMAN; ENSEMBL ID: ENSG00000134962; HGNC ID: 15527
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult10 / 19391215
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal26 / 33603077
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain1 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver7 / 20774333
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland7 / 15327145
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach0 / 966190 
testis9 / 33044227
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P69531
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.45 ± 1.07
Basal Forebrain2.15 ± 0.35
Basal Part of Pons1.69 ± 0.46
Cerebellar Cortex1.83 ± 0.55
Cerebellar Nuclei2.31 ± 0.67
Claustrum2.85 ± 0.8
Epithalamus1.71 ± 0.83
Frontal Lobe1.78 ± 0.57
Globus Pallidus2.19 ± 0.43
Hypothalamus2.1 ± 0.65
Insula1.96 ± 0.76
Limbic Lobe2 ± 0.62
Mesencephalon2.27 ± 0.74
Myelencephalon2.1 ± 0.72
Occipital Lobe2.09 ± 0.64
Parietal Lobe2.04 ± 0.73
Pontine Tegmentum1.97 ± 0.67
Striatum3.28 ± 0.92
Subthalamus2.25 ± 0.77
Temporal Lobe1.84 ± 0.53
Thalamus2 ± 0.66
White Matter2.25 ± 0.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
KlbCBCerebellum4.55
5.33
KlbCTXCerebral cortex4.45
4
KlbHIPHippocampal region4.04
4.03
KlbHPFHippocampal formation4.04
3.7
KlbHYHypothalamus0.41
0.3
KlbLSXLateral septal complex0.31
0.14
KlbMBMidbrain2.36
2.71
KlbMYMedulla4.66
5.91
KlbOLFOlfactory bulb4.88
3.31
KlbPPons2.6
3.17
KlbPALPallidum1.29
1.07
KlbRHPRetrohippocampal region4.25
3.4
KlbsAMYStriatum-like amygdalar nuclei2.28
1.78
KlbSTRStriatum2.28
1.9
KlbSTRdStriatum dorsal region1.98
1.71
KlbSTRvStriatum ventral region3.62
2.87
KlbTHThalamus2.67
2.15
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018