AutismKB 2.0

Annotation Detail for RASGEF1B


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Basic Information Top
Gene Symbol:RASGEF1B ( FLJ31695,GPIG4,MGC46251 )
Gene Full Name: RasGEF domain family, member 1B
Band: 4q21.21
Quick LinksEntrez ID:153020; OMIM: NA; Uniprot ID:RGF1B_HUMAN; ENSEMBL ID: ENSG00000138670; HGNC ID: 24881
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult19 / 19391219
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor4 / 26384515
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal27 / 33603078
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood2 / 12347816
bone0 / 716550 
bone marrow0 / 488010 
brain12 / 110098910
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus1 / 2020949
eye1 / 2110544
heart0 / 896260 
intestine3 / 23447212
kidney1 / 2117774
larynx0 / 241450 
liver1 / 2077434
lung6 / 33697417
lymph0 / 442700 
lymph node1 / 9161010
mammary gland0 / 1532710 
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate1 / 1893455
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11153_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.11 ± 1.06
Basal Forebrain2.68 ± 0.41
Basal Part of Pons4.35 ± 0.45
Cerebellar Cortex2.33 ± 0.33
Cerebellar Nuclei3.46 ± 0.6
Claustrum3.28 ± 0.75
Epithalamus2.7 ± 1.01
Frontal Lobe2.65 ± 0.74
Globus Pallidus3.01 ± 0.51
Hypothalamus2.88 ± 0.86
Insula2.7 ± 0.52
Limbic Lobe2.84 ± 0.96
Mesencephalon3.07 ± 0.79
Myelencephalon3 ± 0.93
Occipital Lobe3.62 ± 0.85
Parietal Lobe2.96 ± 0.81
Pontine Tegmentum2.88 ± 0.77
Striatum4.89 ± 0.51
Subthalamus3.7 ± 0.54
Temporal Lobe3.04 ± 0.92
Thalamus3.5 ± 0.88
White Matter3.44 ± 0.67
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rasgef1bCBCerebellum21.67
26.56
Rasgef1bCTXCerebral cortex100
100
Rasgef1bHIPHippocampal region17.61
21.16
Rasgef1bHPFHippocampal formation38.62
46.63
Rasgef1bHYHypothalamus23.38
22.76
Rasgef1bLSXLateral septal complex36.34
31.17
Rasgef1bMBMidbrain43.22
47.1
Rasgef1bMYMedulla43.28
65.97
Rasgef1bOLFOlfactory bulb87.57
93.5
Rasgef1bPPons42.61
60.16
Rasgef1bPALPallidum37.88
40.41
Rasgef1bRHPRetrohippocampal region70.96
78.63
Rasgef1bsAMYStriatum-like amygdalar nuclei21.99
19.32
Rasgef1bSTRStriatum100
100
Rasgef1bSTRdStriatum dorsal region100
100
Rasgef1bSTRvStriatum ventral region96.87
90.41
Rasgef1bTHThalamus97.28
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018