AutismKB 2.0

Annotation Detail for CYBA


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Basic Information Top
Gene Symbol:CYBA ( p22-PHOX )
Gene Full Name: cytochrome b-245, alpha polypeptide
Band: 16q24.2
Quick LinksEntrez ID:1535; OMIM: 608508; Uniprot ID:CY24A_HUMAN; ENSEMBL ID: ENSG00000051523; HGNC ID: 2577
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst2 / 6231932
fetus31 / 56401254
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult134 / 193912169
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor9 / 9417895
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor17 / 114246148
esophageal tumor4 / 17290231
gastrointestinal tumor5 / 11936941
germ cell tumor10 / 26384537
glioma5 / 10688346
head and neck tumor4 / 13630229
kidney tumor4 / 6895958
leukemia33 / 95842344
liver tumor5 / 9635951
lung tumor7 / 10312767
lymphoma2 / 7175527
non-neoplasia6 / 9725061
normal252 / 336030774
ovarian tumor0 / 766820 
pancreatic tumor33 / 104616315
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor12 / 12494996
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites4 / 4001599
bladder0 / 297570 
blood29 / 123478234
bone3 / 7165541
bone marrow6 / 48801122
brain26 / 110098923
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus4 / 20209197
eye14 / 21105466
heart7 / 8962678
intestine44 / 234472187
kidney25 / 211777118
larynx0 / 241450 
liver8 / 20774338
lung23 / 33697468
lymph1 / 4427022
lymph node30 / 91610327
mammary gland11 / 15327171
mouth3 / 6705244
muscle0 / 1077150 
nerve0 / 157680 
ovary2 / 10205119
pancreas36 / 214812167
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate16 / 18934584
salivary gland1 / 2015549
skin19 / 21057490
spleen14 / 53952259
stomach8 / 9661982
testis4 / 33044212
thymus10 / 81131123
thyroid1 / 4747321
tonsil9 / 16999529
trachea1 / 5241319
umbilical cord0 / 136800 
uterus11 / 23287847
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203028_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts247.15
Adipocyte23.15
AdrenalCortex6.85
Adrenalgland20.8
Amygdala10.5
Appendix7.75
AtrioventricularNode3.65
BDCA4+_DentriticCells2851.55
Bonemarrow585.4
BronchialEpithelialCells53.8
CD105+_Endothelial154.45
CD14+_Monocytes1469.35
CD19+_BCells(neg._sel.)1333.6
CD33+_Myeloid2311.05
CD34+797.1
CD4+_Tcells478.2
CD56+_NKCells2081.4
CD71+_EarlyErythroid5.3
CD8+_Tcells544.55
CardiacMyocytes122.35
Caudatenucleus8.6
Cerebellum3.8
CerebellumPeduncles8.55
CiliaryGanglion4.7
CingulateCortex7.75
Colorectaladenocarcinoma314.75
DorsalRootGanglion3.65
FetalThyroid138.3
Fetalbrain9.5
Fetalliver37.9
Fetallung248.05
GlobusPallidus3.5
Heart777.45
Hypothalamus15.45
Kidney117.3
Leukemia_chronicMyelogenousK-562258.35
Leukemia_promyelocytic-HL-60194.5
Leukemialymphoblastic(MOLT-4)57.65
Liver231.3
Lung1415
Lymphnode505.8
Lymphoma_burkitts(Daudi)139.05
Lymphoma_burkitts(Raji)508.4
MedullaOblongata8.25
OccipitalLobe5.9
OlfactoryBulb8.15
Ovary4.3
Pancreas206.9
PancreaticIslet32.7
ParietalLobe5.05
Pituitary15.5
Placenta88.8
Pons7.6
PrefrontalCortex6.1
Prostate179.65
Salivarygland4.4
SkeletalMuscle9.8
Skin3.6
SmoothMuscle376.6
Spinalcord23.8
SubthalamicNucleus4.25
SuperiorCervicalGanglion7.1
TemporalLobe6.35
Testis7.45
TestisGermCell4.15
TestisIntersitial4.4
TestisLeydigCell4.7
TestisSeminiferousTubule3.7
Thalamus7.1
Thymus258.8
Thyroid626.5
Tongue4.85
Tonsil317.8
Trachea77.6
TrigeminalGanglion6.6
Uterus58.55
UterusCorpus7.4
WholeBlood1423
Wholebrain17.6
colon346.9
pineal_day6.62
pineal_night5.76
retina43.8
small_intestine253.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_176_PI417507815
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.33 ± 0.46
Basal Forebrain6.32 ± 0.53
Basal Part of Pons5.73 ± 0.49
Cerebellar Cortex4.96 ± 0.34
Cerebellar Nuclei6.4 ± 0.55
Claustrum4.72 ± 0.53
Epithalamus6.53 ± 0.94
Frontal Lobe5.41 ± 0.64
Globus Pallidus6.87 ± 0.19
Hypothalamus5.99 ± 1.2
Insula5.41 ± 0.46
Limbic Lobe5.12 ± 0.57
Mesencephalon5.7 ± 0.63
Myelencephalon5.59 ± 0.77
Occipital Lobe5.18 ± 0.68
Parietal Lobe5.31 ± 0.78
Pontine Tegmentum5.31 ± 0.76
Striatum6.95 ± 0.57
Subthalamus5.75 ± 1.2
Temporal Lobe5.32 ± 0.6
Thalamus5.33 ± 0.57
White Matter5.77 ± 0.64
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
CybaCBCerebellum2.11
2.09
CybaCTXCerebral cortex5.17
1.85
CybaHIPHippocampal region1.59
1.49
CybaHPFHippocampal formation2.43
1.73
CybaHYHypothalamus0.3
0.22
CybaLSXLateral septal complex0.51
0.34
CybaMBMidbrain0.82
0.77
CybaMYMedulla1.74
1.54
CybaOLFOlfactory bulb5.63
3.51
CybaPPons0.95
0.68
CybaPALPallidum0.48
0.23
CybaRHPRetrohippocampal region3.72
2.01
CybasAMYStriatum-like amygdalar nuclei0.85
0.8
CybaSTRStriatum0.66
0.29
CybaSTRdStriatum dorsal region0.62
0.24
CybaSTRvStriatum ventral region0.75
0.26
CybaTHThalamus1.04
0.92
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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