AutismKB 2.0

Annotation Detail for ADRB2


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Basic Information Top
Gene Symbol:ADRB2 ( ADRB2R,ADRBR,B2AR,BAR,BETA2AR )
Gene Full Name: adrenergic, beta-2-, receptor, surface
Band: 5q32
Quick LinksEntrez ID:154; OMIM: 109690; Uniprot ID:ADRB2_HUMAN; ENSEMBL ID: ENSG00000169252; HGNC ID: 286
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus8 / 56401214
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult29 / 193912114
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal53 / 336030715
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood5 / 12347840
bone2 / 7165527
bone marrow0 / 488010 
brain12 / 110098910
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye3 / 21105414
heart2 / 8962622
intestine4 / 23447217
kidney4 / 21177718
larynx1 / 2414541
liver2 / 2077439
lung4 / 33697411
lymph0 / 442700 
lymph node1 / 9161010
mammary gland4 / 15327126
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta7 / 28082524
prostate5 / 18934526
salivary gland0 / 201550 
skin0 / 2105740 
spleen4 / 5395274
stomach3 / 9661931
testis0 / 3304420 
thymus1 / 8113112
thyroid2 / 4747342
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206170_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.9
Adipocyte4.7
AdrenalCortex5.15
Adrenalgland4.15
Amygdala4.95
Appendix31.3
AtrioventricularNode3.8
BDCA4+_DentriticCells15.3
Bonemarrow32.35
BronchialEpithelialCells40.6
CD105+_Endothelial4.8
CD14+_Monocytes25.7
CD19+_BCells(neg._sel.)5.05
CD33+_Myeloid101.45
CD34+6.1
CD4+_Tcells11.95
CD56+_NKCells259.75
CD71+_EarlyErythroid4.45
CD8+_Tcells53.45
CardiacMyocytes6
Caudatenucleus4.25
Cerebellum3.8
CerebellumPeduncles5.35
CiliaryGanglion3.85
CingulateCortex4.8
Colorectaladenocarcinoma4.7
DorsalRootGanglion3.95
FetalThyroid4.6
Fetalbrain4.65
Fetalliver4.1
Fetallung3.95
GlobusPallidus3.55
Heart6.05
Hypothalamus5
Kidney3.9
Leukemia_chronicMyelogenousK-5624.3
Leukemia_promyelocytic-HL-604.15
Leukemialymphoblastic(MOLT-4)3.8
Liver6.3
Lung91.85
Lymphnode4.1
Lymphoma_burkitts(Daudi)6.05
Lymphoma_burkitts(Raji)6.6
MedullaOblongata4.5
OccipitalLobe4.25
OlfactoryBulb4.15
Ovary3.1
Pancreas3.85
PancreaticIslet5.05
ParietalLobe5.1
Pituitary5.5
Placenta9.15
Pons4.6
PrefrontalCortex5.9
Prostate5.65
Salivarygland3.85
SkeletalMuscle6
Skin8.55
SmoothMuscle5.25
Spinalcord5.1
SubthalamicNucleus4.3
SuperiorCervicalGanglion12.1
TemporalLobe4.3
Testis4.05
TestisGermCell3.95
TestisIntersitial3.9
TestisLeydigCell4.7
TestisSeminiferousTubule4.05
Thalamus4.8
Thymus3.85
Thyroid5.9
Tongue4.8
Tonsil4.65
Trachea3.95
TrigeminalGanglion23.15
Uterus3.85
UterusCorpus4.4
WholeBlood126.25
Wholebrain4
colon4.7
pineal_day6
pineal_night5.64
retina5.75
small_intestine4.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P145024
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.12 ± 0.55
Basal Forebrain5.32 ± 0.42
Basal Part of Pons5.17 ± 0.35
Cerebellar Cortex4.77 ± 0.32
Cerebellar Nuclei5.89 ± 0.28
Claustrum4.75 ± 0.78
Epithalamus5.42 ± 0.57
Frontal Lobe5.22 ± 0.46
Globus Pallidus6.59 ± 0.29
Hypothalamus4.66 ± 0.86
Insula5.33 ± 0.34
Limbic Lobe5.37 ± 0.55
Mesencephalon5.39 ± 0.64
Myelencephalon5.29 ± 0.49
Occipital Lobe5.28 ± 0.5
Parietal Lobe5.18 ± 0.51
Pontine Tegmentum5.32 ± 0.57
Striatum5.61 ± 0.48
Subthalamus5.38 ± 0.32
Temporal Lobe5.28 ± 0.47
Thalamus5.36 ± 0.44
White Matter5.77 ± 0.43
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Adrb2CBCerebellum7.16
7.19
Adrb2CTXCerebral cortex7.61
5.03
Adrb2HIPHippocampal region4.53
3.89
Adrb2HPFHippocampal formation5.84
4.75
Adrb2HYHypothalamus5.37
4.63
Adrb2LSXLateral septal complex1.92
2.45
Adrb2MBMidbrain5.17
5
Adrb2MYMedulla10.18
10.17
Adrb2OLFOlfactory bulb24.13
17.31
Adrb2PPons11.2
12.7
Adrb2PALPallidum4.71
3.59
Adrb2RHPRetrohippocampal region8.36
6.12
Adrb2sAMYStriatum-like amygdalar nuclei5.86
4.08
Adrb2STRStriatum4.2
3.12
Adrb2STRdStriatum dorsal region3.61
2.83
Adrb2STRvStriatum ventral region6.17
3.68
Adrb2THThalamus3.89
3.26
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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