AutismKB 2.0

Annotation Detail for CYP1B1


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Basic Information Top
Gene Symbol:CYP1B1 ( CP1B,GLC3A,P4501B1 )
Gene Full Name: cytochrome P450, family 1, subfamily B, polypeptide 1
Band: 2p22.2
Quick LinksEntrez ID:1545; OMIM: 601771; Uniprot ID:CP1B1_HUMAN; ENSEMBL ID: ENSG00000138061; HGNC ID: 2597
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst3 / 6231948
fetus52 / 56401292
neonate10 / 31097321
infant0 / 236200 
juvenile2 / 5555635
adult131 / 193912167
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor12 / 94178127
cervical tumor0 / 343660 
chondrosarcoma15 / 82823181
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor3 / 11936925
germ cell tumor16 / 26384560
glioma15 / 106883140
head and neck tumor3 / 13630222
kidney tumor6 / 6895987
leukemia3 / 9584231
liver tumor7 / 9635972
lung tumor13 / 103127126
lymphoma0 / 717550 
non-neoplasia27 / 97250277
normal366 / 3360307108
ovarian tumor0 / 766820 
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer10 / 10268097
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood6 / 12347848
bone8 / 71655111
bone marrow8 / 48801163
brain61 / 110098955
cervix2 / 4817141
connective tissue111 / 149255743
ear12 / 16212740
embryonic tissue14 / 21572264
esophagus1 / 2020949
eye20 / 21105494
heart5 / 8962655
intestine6 / 23447225
kidney22 / 211777103
larynx0 / 241450 
liver10 / 20774348
lung45 / 336974133
lymph0 / 442700 
lymph node0 / 916100 
mammary gland23 / 153271150
mouth3 / 6705244
muscle0 / 1077150 
nerve3 / 15768190
ovary0 / 1020510 
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta3 / 28082510
prostate20 / 189345105
salivary gland0 / 201550 
skin36 / 210574170
spleen13 / 53952240
stomach4 / 9661941
testis18 / 33044254
thymus15 / 81131184
thyroid1 / 4747321
tonsil0 / 169990 
trachea19 / 52413362
umbilical cord0 / 136800 
uterus15 / 23287864
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202436_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts13.95
Adipocyte75.9
AdrenalCortex25.95
Adrenalgland16.6
Amygdala18.4
Appendix88.65
AtrioventricularNode94.3
BDCA4+_DentriticCells18.5
Bonemarrow15.6
BronchialEpithelialCells12.3
CD105+_Endothelial174.55
CD14+_Monocytes1140.15
CD19+_BCells(neg._sel.)5.95
CD33+_Myeloid1415.6
CD34+5.55
CD4+_Tcells4.9
CD56+_NKCells8.75
CD71+_EarlyErythroid10
CD8+_Tcells4.2
CardiacMyocytes100.5
Caudatenucleus15.05
Cerebellum11.55
CerebellumPeduncles17.35
CiliaryGanglion285
CingulateCortex16.65
Colorectaladenocarcinoma10.85
DorsalRootGanglion116.95
FetalThyroid19.45
Fetalbrain13.8
Fetalliver11.6
Fetallung13.8
GlobusPallidus7
Heart21.7
Hypothalamus19.1
Kidney17.55
Leukemia_chronicMyelogenousK-56216.55
Leukemia_promyelocytic-HL-6012.1
Leukemialymphoblastic(MOLT-4)9.7
Liver18.6
Lung128.5
Lymphnode86.55
Lymphoma_burkitts(Daudi)16.25
Lymphoma_burkitts(Raji)15.3
MedullaOblongata16
OccipitalLobe15
OlfactoryBulb556.35
Ovary27.25
Pancreas16.3
PancreaticIslet19.9
ParietalLobe18.6
Pituitary24.65
Placenta12.2
Pons16.75
PrefrontalCortex33.25
Prostate731.3
Salivarygland21.7
SkeletalMuscle31.75
Skin13.5
SmoothMuscle230.6
Spinalcord56.8
SubthalamicNucleus12.3
SuperiorCervicalGanglion94.75
TemporalLobe16.35
Testis11.05
TestisGermCell40.9
TestisIntersitial17.35
TestisLeydigCell23.5
TestisSeminiferousTubule28
Thalamus10.3
Thymus39.45
Thyroid50.05
Tongue17.5
Tonsil6.55
Trachea274.75
TrigeminalGanglion163.5
Uterus340.15
UterusCorpus51.1
WholeBlood97.45
Wholebrain13.35
colon11.45
pineal_day143.18
pineal_night122.14
retina380.625
small_intestine18
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15785_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.65 ± 1.08
Basal Forebrain2.45 ± 0.69
Basal Part of Pons2 ± 0.39
Cerebellar Cortex1.9 ± 0.57
Cerebellar Nuclei2.56 ± 0.68
Claustrum2.84 ± 0.7
Epithalamus2.17 ± 0.92
Frontal Lobe2.15 ± 0.75
Globus Pallidus2.68 ± 0.51
Hypothalamus2.31 ± 0.78
Insula2.42 ± 0.56
Limbic Lobe2.11 ± 0.65
Mesencephalon2.31 ± 0.67
Myelencephalon2.28 ± 0.69
Occipital Lobe2.28 ± 0.69
Parietal Lobe2.25 ± 0.71
Pontine Tegmentum2.36 ± 0.87
Striatum2.66 ± 0.6
Subthalamus2.34 ± 0.81
Temporal Lobe2.27 ± 0.8
Thalamus2.21 ± 0.66
White Matter2.36 ± 0.11
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cyp1b1CBCerebellum5.67
7.27
Cyp1b1CTXCerebral cortex3.67
3.48
Cyp1b1HIPHippocampal region4.82
4.86
Cyp1b1HPFHippocampal formation4.25
4.32
Cyp1b1HYHypothalamus7.03
6.63
Cyp1b1LSXLateral septal complex3.09
4.75
Cyp1b1MBMidbrain5.45
6.9
Cyp1b1MYMedulla11.19
14.82
Cyp1b1OLFOlfactory bulb14.02
14.15
Cyp1b1PPons14.98
23.89
Cyp1b1PALPallidum2.49
2.18
Cyp1b1RHPRetrohippocampal region2.68
3.1
Cyp1b1sAMYStriatum-like amygdalar nuclei1.24
1.17
Cyp1b1STRStriatum3.66
3.87
Cyp1b1STRdStriatum dorsal region1.84
1.95
Cyp1b1STRvStriatum ventral region11.28
10.49
Cyp1b1THThalamus3.48
3.39
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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