AutismKB 2.0

Annotation Detail for ADRBK1


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Basic Information Top
Gene Symbol:ADRBK1 ( BARK1,BETA-ARK1,FLJ16718,GRK2 )
Gene Full Name: adrenergic, beta, receptor kinase 1
Band: 11q13.1
Quick LinksEntrez ID:156; OMIM: 109635; Uniprot ID:ARBK1_HUMAN; ENSEMBL ID: ENSG00000173020; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus17 / 56401230
neonate0 / 310970 
infant1 / 2362042
juvenile8 / 55556143
adult178 / 193912191
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor5 / 34366145
chondrosarcoma8 / 8282396
colorectal tumor17 / 114246148
esophageal tumor0 / 172900 
gastrointestinal tumor14 / 119369117
germ cell tumor22 / 26384583
glioma8 / 10688374
head and neck tumor40 / 136302293
kidney tumor5 / 6895972
leukemia28 / 95842292
liver tumor2 / 9635920
lung tumor13 / 103127126
lymphoma40 / 71755557
non-neoplasia4 / 9725041
normal157 / 336030746
ovarian tumor4 / 7668252
pancreatic tumor16 / 104616152
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer12 / 102680116
retinoblastoma7 / 46356151
skin tumor7 / 12494956
soft tissue/muscle tissue tumor15 / 125191119
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood29 / 123478234
bone5 / 7165569
bone marrow5 / 48801102
brain35 / 110098931
cervix6 / 48171124
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye17 / 21105480
heart0 / 896260 
intestine34 / 234472145
kidney8 / 21177737
larynx0 / 241450 
liver4 / 20774319
lung33 / 33697497
lymph30 / 44270677
lymph node18 / 91610196
mammary gland7 / 15327145
mouth4 / 6705259
muscle13 / 107715120
nerve4 / 15768253
ovary5 / 10205148
pancreas17 / 21481279
parathyroid0 / 205390 
pharynx32 / 41328774
pituitary gland1 / 1658560
placenta10 / 28082535
prostate19 / 189345100
salivary gland3 / 20155148
skin7 / 21057433
spleen3 / 5395255
stomach9 / 9661993
testis5 / 33044215
thymus8 / 8113198
thyroid2 / 4747342
tonsil10 / 16999588
trachea0 / 524130 
umbilical cord0 / 136800 
uterus18 / 23287877
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201401_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts210.9
Adipocyte13.2
AdrenalCortex16.35
Adrenalgland11.65
Amygdala29.35
Appendix13.2
AtrioventricularNode10
BDCA4+_DentriticCells315.75
Bonemarrow85.4
BronchialEpithelialCells12
CD105+_Endothelial30.65
CD14+_Monocytes233.45
CD19+_BCells(neg._sel.)149.5
CD33+_Myeloid468.2
CD34+194.75
CD4+_Tcells260.25
CD56+_NKCells223
CD71+_EarlyErythroid34.35
CD8+_Tcells221.95
CardiacMyocytes15.7
Caudatenucleus11.9
Cerebellum13
CerebellumPeduncles15.35
CiliaryGanglion8.9
CingulateCortex15.3
Colorectaladenocarcinoma43
DorsalRootGanglion8.5
FetalThyroid7.75
Fetalbrain14.85
Fetalliver12
Fetallung11.3
GlobusPallidus11.05
Heart25.35
Hypothalamus14.05
Kidney10.8
Leukemia_chronicMyelogenousK-56213.5
Leukemia_promyelocytic-HL-6018.25
Leukemialymphoblastic(MOLT-4)31.4
Liver17.35
Lung32.55
Lymphnode30.45
Lymphoma_burkitts(Daudi)15.95
Lymphoma_burkitts(Raji)68.35
MedullaOblongata16.15
OccipitalLobe11.1
OlfactoryBulb10.45
Ovary9.15
Pancreas11.35
PancreaticIslet12.9
ParietalLobe21.55
Pituitary17.6
Placenta14.55
Pons17.5
PrefrontalCortex38.15
Prostate36.55
Salivarygland10.65
SkeletalMuscle26.25
Skin9.45
SmoothMuscle11.1
Spinalcord15.85
SubthalamicNucleus13.2
SuperiorCervicalGanglion13.4
TemporalLobe13.85
Testis11.1
TestisGermCell9.7
TestisIntersitial9.6
TestisLeydigCell14.25
TestisSeminiferousTubule10.5
Thalamus12.2
Thymus23.85
Thyroid15.7
Tongue13.85
Tonsil45.35
Trachea11.55
TrigeminalGanglion11.8
Uterus10.25
UterusCorpus13.7
WholeBlood200.45
Wholebrain29.1
colon13.95
pineal_day15.84
pineal_night19.6
retina19.175
small_intestine13.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_68_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.49 ± 1.06
Basal Forebrain1.91 ± 0.28
Basal Part of Pons2.12 ± 0.83
Cerebellar Cortex2.51 ± 0.76
Cerebellar Nuclei2.55 ± 1.16
Claustrum2.56 ± 0.62
Epithalamus1.7 ± 0.83
Frontal Lobe2.26 ± 0.8
Globus Pallidus1.7 ± 0.58
Hypothalamus2.11 ± 0.61
Insula2.05 ± 0.69
Limbic Lobe2.03 ± 0.69
Mesencephalon2.28 ± 0.83
Myelencephalon2.06 ± 0.68
Occipital Lobe1.7 ± 0.77
Parietal Lobe2.14 ± 0.67
Pontine Tegmentum2.06 ± 0.72
Striatum1.35 ± 0.77
Subthalamus2.28 ± 0.87
Temporal Lobe2.18 ± 0.79
Thalamus2.07 ± 0.81
White Matter2.07 ± 0.27
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Adrbk1CBCerebellum7.57
8.92
Adrbk1CTXCerebral cortex5.87
4.86
Adrbk1HIPHippocampal region10.32
10.31
Adrbk1HPFHippocampal formation10.48
9.54
Adrbk1HYHypothalamus2.64
1.99
Adrbk1LSXLateral septal complex0.04
0
Adrbk1MBMidbrain4.67
4.35
Adrbk1MYMedulla12.44
12.6
Adrbk1OLFOlfactory bulb5.05
3.24
Adrbk1PPons7.54
8.1
Adrbk1PALPallidum2.89
2.71
Adrbk1RHPRetrohippocampal region10.88
8.67
Adrbk1sAMYStriatum-like amygdalar nuclei5.55
4.2
Adrbk1STRStriatum1.26
1.04
Adrbk1STRdStriatum dorsal region0.81
0.75
Adrbk1STRvStriatum ventral region0.92
0.69
Adrbk1THThalamus3.44
2.93
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ARBK1_HUMAN_2 26 2 27 ADLEAVLADVSYLMAMEKSKATPAAR PRIDE
ARBK1_HUMAN_344 20 344 363 KKPHASVGTHGYMAPEVLQK PRIDE
PAp00024612 21 70 90 DFCLNHLEEARPLVEFYEEIK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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