AutismKB 2.0

Annotation Detail for ADRBK2


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Basic Information Top
Gene Symbol:ADRBK2 ( BARK2,GRK3 )
Gene Full Name: adrenergic, beta, receptor kinase 2
Band: 22q11|22q12.1
Quick LinksEntrez ID:157; OMIM: 109636; Uniprot ID:ARBK2_HUMAN; ENSEMBL ID: ENSG00000100077; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus27 / 56401247
neonate0 / 310970 
infant4 / 23620169
juvenile3 / 5555653
adult56 / 193912128
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor3 / 11424626
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor16 / 26384560
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia4 / 9584241
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal160 / 336030747
ovarian tumor2 / 7668226
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS12 / 12568095
prostate cancer6 / 10268058
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood7 / 12347856
bone3 / 7165541
bone marrow0 / 488010 
brain40 / 110098936
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus1 / 2020949
eye4 / 21105418
heart2 / 8962622
intestine5 / 23447221
kidney3 / 21177714
larynx0 / 241450 
liver6 / 20774328
lung16 / 33697447
lymph0 / 442700 
lymph node23 / 91610251
mammary gland3 / 15327119
mouth0 / 670520 
muscle5 / 10771546
nerve2 / 15768126
ovary3 / 10205129
pancreas17 / 21481279
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta6 / 28082521
prostate9 / 18934547
salivary gland0 / 201550 
skin9 / 21057442
spleen2 / 5395237
stomach1 / 9661910
testis23 / 33044269
thymus2 / 8113124
thyroid0 / 474730 
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204183_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.35
Adipocyte4.1
AdrenalCortex4.35
Adrenalgland3.55
Amygdala4.3
Appendix4.1
AtrioventricularNode3.15
BDCA4+_DentriticCells4.9
Bonemarrow4.1
BronchialEpithelialCells4
CD105+_Endothelial4.2
CD14+_Monocytes9.65
CD19+_BCells(neg._sel.)5
CD33+_Myeloid5.7
CD34+6.05
CD4+_Tcells4.4
CD56+_NKCells5.15
CD71+_EarlyErythroid3.85
CD8+_Tcells4.05
CardiacMyocytes5.35
Caudatenucleus3.65
Cerebellum3.3
CerebellumPeduncles4.65
CiliaryGanglion2.9
CingulateCortex4.3
Colorectaladenocarcinoma4.1
DorsalRootGanglion3.25
FetalThyroid4
Fetalbrain4
Fetalliver3.6
Fetallung3.35
GlobusPallidus3.05
Heart5.3
Hypothalamus4.4
Kidney3.45
Leukemia_chronicMyelogenousK-5623.7
Leukemia_promyelocytic-HL-603.65
Leukemialymphoblastic(MOLT-4)3.3
Liver5.5
Lung4.45
Lymphnode3.55
Lymphoma_burkitts(Daudi)5.25
Lymphoma_burkitts(Raji)5.85
MedullaOblongata3.7
OccipitalLobe3.75
OlfactoryBulb3.25
Ovary2.7
Pancreas3.3
PancreaticIslet4.35
ParietalLobe4.35
Pituitary4.8
Placenta4.2
Pons3.9
PrefrontalCortex5.05
Prostate4.75
Salivarygland3.3
SkeletalMuscle4.9
Skin3.2
SmoothMuscle4.6
Spinalcord4.4
SubthalamicNucleus3.75
SuperiorCervicalGanglion4.7
TemporalLobe3.75
Testis3.6
TestisGermCell3.45
TestisIntersitial3.55
TestisLeydigCell5.45
TestisSeminiferousTubule6.35
Thalamus4.2
Thymus3.3
Thyroid5.1
Tongue4.05
Tonsil4
Trachea3.4
TrigeminalGanglion4.2
Uterus3.3
UterusCorpus3.7
WholeBlood4.6
Wholebrain3.4
colon4.15
pineal_day5.12
pineal_night5.08
retina4.9
small_intestine3.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P251686
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.06 ± 0.62
Basal Forebrain8.26 ± 0.31
Basal Part of Pons8.97 ± 0.33
Cerebellar Cortex8.76 ± 0.48
Cerebellar Nuclei7.73 ± 0.5
Claustrum8.46 ± 0.51
Epithalamus7.79 ± 0.58
Frontal Lobe8.87 ± 0.5
Globus Pallidus8.19 ± 0.46
Hypothalamus7.84 ± 0.7
Insula8.86 ± 0.31
Limbic Lobe9.28 ± 0.58
Mesencephalon8.43 ± 0.63
Myelencephalon8.62 ± 0.64
Occipital Lobe8.67 ± 0.46
Parietal Lobe8.97 ± 0.43
Pontine Tegmentum8.5 ± 0.55
Striatum7.12 ± 0.87
Subthalamus8.32 ± 0.44
Temporal Lobe8.82 ± 0.38
Thalamus8.43 ± 0.47
White Matter5.98 ± 0.87
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Adrbk2CBCerebellum46.88
58.18
Adrbk2CTXCerebral cortex96.66
89.32
Adrbk2HIPHippocampal region59.57
83.85
Adrbk2HPFHippocampal formation81.07
94.68
Adrbk2HYHypothalamus38.04
29.04
Adrbk2LSXLateral septal complex74.83
57.61
Adrbk2MBMidbrain38.57
34.73
Adrbk2MYMedulla36.87
34.91
Adrbk2OLFOlfactory bulb95.58
87.53
Adrbk2PPons29.52
27.43
Adrbk2PALPallidum40.34
34.94
Adrbk2RHPRetrohippocampal region100
100
Adrbk2sAMYStriatum-like amygdalar nuclei67.39
54.4
Adrbk2STRStriatum33.43
28.99
Adrbk2STRdStriatum dorsal region24.25
22.79
Adrbk2STRvStriatum ventral region32.25
26.24
Adrbk2THThalamus95.43
92.34
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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