AutismKB 2.0

Annotation Detail for PRUNE2


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Basic Information Top
Gene Symbol:PRUNE2 ( A214N16.3,BMCC1,BNIPXL,C9orf65,DKFZp762K117,FLJ50060,FLJ54876,FLJ59118,KIAA0367,RP11-58J3.2,bA214N16.3 )
Gene Full Name: prune homolog 2 (Drosophila)
Band: 9q21.2
Quick LinksEntrez ID:158471; OMIM: 610691; Uniprot ID:PRUN2_HUMAN; ENSEMBL ID: ENSG00000106772; HGNC ID: 25209
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus34 / 56401260
neonate0 / 310970 
infant1 / 2362042
juvenile7 / 55556125
adult123 / 193912163
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor8 / 26384530
glioma6 / 10688356
head and neck tumor2 / 13630214
kidney tumor5 / 6895972
leukemia3 / 9584231
liver tumor1 / 9635910
lung tumor6 / 10312758
lymphoma0 / 717550 
non-neoplasia7 / 9725071
normal430 / 3360307127
ovarian tumor8 / 76682104
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites3 / 4001574
bladder0 / 297570 
blood3 / 12347824
bone1 / 7165513
bone marrow0 / 488010 
brain320 / 1100989290
cervix0 / 481710 
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye25 / 211054118
heart0 / 896260 
intestine6 / 23447225
kidney14 / 21177766
larynx0 / 241450 
liver1 / 2077434
lung13 / 33697438
lymph0 / 442700 
lymph node0 / 916100 
mammary gland4 / 15327126
mouth0 / 670520 
muscle3 / 10771527
nerve6 / 15768380
ovary9 / 10205188
pancreas14 / 21481265
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland8 / 16585482
placenta13 / 28082546
prostate13 / 18934568
salivary gland0 / 201550 
skin7 / 21057433
spleen2 / 5395237
stomach1 / 9661910
testis9 / 33044227
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea13 / 52413248
umbilical cord1 / 1368073
uterus20 / 23287885
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212805_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.45
Adipocyte264.5
AdrenalCortex9.9
Adrenalgland7.75
Amygdala329.75
Appendix72.1
AtrioventricularNode7.35
BDCA4+_DentriticCells8.2
Bonemarrow8.95
BronchialEpithelialCells6.65
CD105+_Endothelial6.85
CD14+_Monocytes7.15
CD19+_BCells(neg._sel.)7
CD33+_Myeloid11.7
CD34+8.1
CD4+_Tcells6.95
CD56+_NKCells7.6
CD71+_EarlyErythroid6.7
CD8+_Tcells6.05
CardiacMyocytes9.6
Caudatenucleus271.7
Cerebellum182.4
CerebellumPeduncles313.3
CiliaryGanglion199.05
CingulateCortex245.75
Colorectaladenocarcinoma6.85
DorsalRootGanglion478.05
FetalThyroid7.7
Fetalbrain33.35
Fetalliver8.15
Fetallung6.4
GlobusPallidus99.6
Heart11.35
Hypothalamus513.2
Kidney7.7
Leukemia_chronicMyelogenousK-5628.1
Leukemia_promyelocytic-HL-607.15
Leukemialymphoblastic(MOLT-4)8.05
Liver10.65
Lung7.5
Lymphnode8.75
Lymphoma_burkitts(Daudi)10.55
Lymphoma_burkitts(Raji)7.75
MedullaOblongata293.45
OccipitalLobe266.75
OlfactoryBulb91.35
Ovary6.15
Pancreas7.55
PancreaticIslet88.5
ParietalLobe260.85
Pituitary426.7
Placenta9.1
Pons131.45
PrefrontalCortex609.7
Prostate64.6
Salivarygland33.85
SkeletalMuscle10.45
Skin6.9
SmoothMuscle7.95
Spinalcord270.9
SubthalamicNucleus186
SuperiorCervicalGanglion14.3
TemporalLobe106.3
Testis6.5
TestisGermCell38.2
TestisIntersitial7.7
TestisLeydigCell14.45
TestisSeminiferousTubule7.4
Thalamus346.45
Thymus5.45
Thyroid8.2
Tongue13.45
Tonsil9.35
Trachea14.85
TrigeminalGanglion70.6
Uterus251.05
UterusCorpus68.2
WholeBlood7.45
Wholebrain126.9
colon60.45
pineal_day191.84
pineal_night229.28
retina206.9
small_intestine24.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P43746
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.56 ± 0.86
Basal Forebrain6.85 ± 0.43
Basal Part of Pons6.91 ± 0.37
Cerebellar Cortex6.53 ± 0.39
Cerebellar Nuclei7.93 ± 0.45
Claustrum5.68 ± 0.95
Epithalamus6.88 ± 0.62
Frontal Lobe6.77 ± 0.79
Globus Pallidus8.1 ± 0.38
Hypothalamus6.48 ± 0.73
Insula5.99 ± 0.55
Limbic Lobe6.04 ± 0.88
Mesencephalon6.74 ± 0.93
Myelencephalon6.61 ± 0.54
Occipital Lobe6.1 ± 0.93
Parietal Lobe6.71 ± 0.64
Pontine Tegmentum6.76 ± 0.77
Striatum6.29 ± 0.82
Subthalamus6.85 ± 0.57
Temporal Lobe6.22 ± 0.67
Thalamus7.17 ± 0.43
White Matter9.29 ± 0.69
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
A230083H22RikCBCerebellum84.99
100
A230083H22RikCTXCerebral cortex49.05
44.41
A230083H22RikHIPHippocampal region30.82
45.07
A230083H22RikHPFHippocampal formation40.38
50.34
A230083H22RikHYHypothalamus40.11
40.52
A230083H22RikLSXLateral septal complex34.15
29.86
A230083H22RikMBMidbrain51.53
62.92
A230083H22RikMYMedulla56.63
85.41
A230083H22RikOLFOlfactory bulb76.05
83.03
A230083H22RikPPons51.88
78.87
A230083H22RikPALPallidum43.83
58.25
A230083H22RikRHPRetrohippocampal region55
56.61
A230083H22RiksAMYStriatum-like amygdalar nuclei37.85
40.8
A230083H22RikSTRStriatum20.16
20.79
A230083H22RikSTRdStriatum dorsal region14.66
16.22
A230083H22RikSTRvStriatum ventral region24.76
22.3
A230083H22RikTHThalamus71.96
78.38
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00040174 24 2583 2606 ETGLQGTQLASFPDTCQPASLNER Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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