AutismKB 2.0

Annotation Detail for CYP17A1


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Basic Information Top
Gene Symbol:CYP17A1 ( CPT7,CYP17,P450C17,S17AH )
Gene Full Name: cytochrome P450, family 17, subfamily A, polypeptide 1
Band: 10q24.32
Quick LinksEntrez ID:1586; OMIM: 609300; Uniprot ID:CP17A_HUMAN; ENSEMBL ID: ENSG00000148795; HGNC ID: 2593
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus19 / 56401233
neonate0 / 310970 
infant10 / 23620423
juvenile0 / 555560 
adult124 / 193912163
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor31 / 127942423
bladder carcinoma1 / 1747557
breast (mammary gland) tumor8 / 9417884
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal768 / 3360307228
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland723 / 3319721779
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain17 / 110098915
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney20 / 21177794
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland8 / 15327152
mouth0 / 670520 
muscle3 / 10771527
nerve0 / 157680 
ovary7 / 10205168
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis26 / 33044278
thymus0 / 811310 
thyroid4 / 4747384
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205502_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.55
Adipocyte4.55
AdrenalCortex7888.75
Adrenalgland11557.35
Amygdala4.8
Appendix4.8
AtrioventricularNode3.55
BDCA4+_DentriticCells4.8
Bonemarrow4.8
BronchialEpithelialCells4.5
CD105+_Endothelial4.55
CD14+_Monocytes4.85
CD19+_BCells(neg._sel.)4.8
CD33+_Myeloid5.75
CD34+5.8
CD4+_Tcells4.85
CD56+_NKCells5.35
CD71+_EarlyErythroid4.25
CD8+_Tcells4.4
CardiacMyocytes5.85
Caudatenucleus4.1
Cerebellum3.75
CerebellumPeduncles5.25
CiliaryGanglion3.2
CingulateCortex4.7
Colorectaladenocarcinoma4.55
DorsalRootGanglion3.55
FetalThyroid4.45
Fetalbrain4.5
Fetalliver3.95
Fetallung3.75
GlobusPallidus3.5
Heart5.95
Hypothalamus4.95
Kidney111.4
Leukemia_chronicMyelogenousK-5624.1
Leukemia_promyelocytic-HL-604.05
Leukemialymphoblastic(MOLT-4)3.7
Liver6.45
Lung5
Lymphnode16.8
Lymphoma_burkitts(Daudi)5.9
Lymphoma_burkitts(Raji)6.5
MedullaOblongata4.2
OccipitalLobe4.05
OlfactoryBulb3.6
Ovary3.05
Pancreas3.7
PancreaticIslet4.95
ParietalLobe4.9
Pituitary5.3
Placenta4.75
Pons4.35
PrefrontalCortex5.6
Prostate5.35
Salivarygland3.7
SkeletalMuscle5.55
Skin3.55
SmoothMuscle5.2
Spinalcord4.9
SubthalamicNucleus4.25
SuperiorCervicalGanglion5.4
TemporalLobe4.2
Testis42.6
TestisGermCell6.35
TestisIntersitial50.8
TestisLeydigCell72.8
TestisSeminiferousTubule3.9
Thalamus4.65
Thymus3.6
Thyroid5.85
Tongue4.55
Tonsil4.45
Trachea3.95
TrigeminalGanglion4.75
Uterus3.7
UterusCorpus4.25
WholeBlood5
Wholebrain3.75
colon4.6
pineal_day5.68
pineal_night5.54
retina5.55
small_intestine4.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15855_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.83 ± 1.01
Basal Forebrain2.29 ± 0.25
Basal Part of Pons2.03 ± 0.34
Cerebellar Cortex2.31 ± 0.77
Cerebellar Nuclei2.73 ± 0.73
Claustrum3.37 ± 0.91
Epithalamus2.16 ± 0.78
Frontal Lobe2.27 ± 0.71
Globus Pallidus2.9 ± 0.36
Hypothalamus2.48 ± 0.61
Insula2.36 ± 0.43
Limbic Lobe2.46 ± 0.64
Mesencephalon2.62 ± 0.81
Myelencephalon2.46 ± 0.73
Occipital Lobe2.44 ± 0.6
Parietal Lobe2.5 ± 0.7
Pontine Tegmentum2.47 ± 0.7
Striatum2.62 ± 0.75
Subthalamus2.62 ± 0.75
Temporal Lobe2.34 ± 0.79
Thalamus2.42 ± 0.66
White Matter2.71 ± 0.17
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cyp17a1CBCerebellum3.78
4.51
Cyp17a1CTXCerebral cortex4.58
3.48
Cyp17a1HIPHippocampal region2.64
2.54
Cyp17a1HPFHippocampal formation2.62
2.31
Cyp17a1HYHypothalamus1.17
0.86
Cyp17a1LSXLateral septal complex3.42
2
Cyp17a1MBMidbrain1.1
1.42
Cyp17a1MYMedulla1.09
1.27
Cyp17a1OLFOlfactory bulb6.91
4.68
Cyp17a1PPons3.06
4.08
Cyp17a1PALPallidum2.53
1.77
Cyp17a1RHPRetrohippocampal region2.59
1.92
Cyp17a1sAMYStriatum-like amygdalar nuclei0.67
0.5
Cyp17a1STRStriatum1.97
1.83
Cyp17a1STRdStriatum dorsal region2.11
2.45
Cyp17a1STRvStriatum ventral region1.06
0.66
Cyp17a1THThalamus1.75
2.41
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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