AutismKB 2.0

Annotation Detail for DAB2


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Basic Information Top
Gene Symbol:DAB2 ( DOC-2,DOC2,FLJ26626 )
Gene Full Name: disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
Band: 5p13.1
Quick LinksEntrez ID:1601; OMIM: 601236; Uniprot ID:DAB2_HUMAN; ENSEMBL ID: ENSG00000153071; HGNC ID: 2662
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst0 / 623190 
fetus88 / 564012156
neonate14 / 31097450
infant0 / 236200 
juvenile4 / 5555671
adult402 / 1939121207
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma1 / 1747557
breast (mammary gland) tumor5 / 9417853
cervical tumor12 / 34366349
chondrosarcoma24 / 82823289
colorectal tumor4 / 11424635
esophageal tumor1 / 1729057
gastrointestinal tumor8 / 11936967
germ cell tumor12 / 26384545
glioma8 / 10688374
head and neck tumor14 / 136302102
kidney tumor4 / 6895958
leukemia4 / 9584241
liver tumor14 / 96359145
lung tumor2 / 10312719
lymphoma5 / 7175569
non-neoplasia22 / 97250226
normal675 / 3360307200
ovarian tumor4 / 7668252
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland9 / 33197271
ascites1 / 4001524
bladder0 / 297570 
blood5 / 12347840
bone21 / 71655293
bone marrow5 / 48801102
brain98 / 110098989
cervix12 / 48171249
connective tissue35 / 149255234
ear10 / 16212616
embryonic tissue15 / 21572269
esophagus1 / 2020949
eye18 / 21105485
heart20 / 89626223
intestine16 / 23447268
kidney66 / 211777311
larynx6 / 24145248
liver50 / 207743240
lung35 / 336974103
lymph0 / 442700 
lymph node1 / 9161010
mammary gland20 / 153271130
mouth6 / 6705289
muscle12 / 107715111
nerve2 / 15768126
ovary7 / 10205168
pancreas13 / 21481260
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta232 / 280825826
prostate4 / 18934521
salivary gland1 / 2015549
skin77 / 210574365
spleen12 / 53952222
stomach6 / 9661962
testis16 / 33044248
thymus6 / 8113173
thyroid2 / 4747342
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord3 / 13680219
uterus17 / 23287872
vascular20 / 51780386
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210757_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts3.95
Adipocyte111.35
AdrenalCortex81.25
Adrenalgland177.65
Amygdala3.3
Appendix3.1
AtrioventricularNode2.4
BDCA4+_DentriticCells171.35
Bonemarrow3.55
BronchialEpithelialCells3.05
CD105+_Endothelial3.55
CD14+_Monocytes3.65
CD19+_BCells(neg._sel.)3.35
CD33+_Myeloid4.1
CD34+4
CD4+_Tcells3.4
CD56+_NKCells19.45
CD71+_EarlyErythroid2.9
CD8+_Tcells3
CardiacMyocytes44.6
Caudatenucleus2.8
Cerebellum8
CerebellumPeduncles3.6
CiliaryGanglion4.8
CingulateCortex3.15
Colorectaladenocarcinoma3.15
DorsalRootGanglion3.95
FetalThyroid6.05
Fetalbrain3.15
Fetalliver20.55
Fetallung7.45
GlobusPallidus2.3
Heart7.75
Hypothalamus3.45
Kidney323.9
Leukemia_chronicMyelogenousK-5622.85
Leukemia_promyelocytic-HL-602.75
Leukemialymphoblastic(MOLT-4)2.55
Liver4.1
Lung65.85
Lymphnode64.75
Lymphoma_burkitts(Daudi)3.95
Lymphoma_burkitts(Raji)4.3
MedullaOblongata2.9
OccipitalLobe2.8
OlfactoryBulb4.65
Ovary2.55
Pancreas2.5
PancreaticIslet3.8
ParietalLobe3.25
Pituitary4.25
Placenta1707.55
Pons2.95
PrefrontalCortex3.95
Prostate3.7
Salivarygland4.2
SkeletalMuscle3.65
Skin2.35
SmoothMuscle392.1
Spinalcord3.3
SubthalamicNucleus2.85
SuperiorCervicalGanglion4.9
TemporalLobe3
Testis3.3
TestisGermCell4.75
TestisIntersitial2.65
TestisLeydigCell6.3
TestisSeminiferousTubule2.65
Thalamus3.15
Thymus13.05
Thyroid4.7
Tongue3.05
Tonsil3.05
Trachea12.6
TrigeminalGanglion3.15
Uterus12.5
UterusCorpus39.2
WholeBlood4.05
Wholebrain2.7
colon5.45
pineal_day3.96
pineal_night3.84
retina15.1
small_intestine14.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P166135
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.28 ± 1.21
Basal Forebrain1.75 ± 0.24
Basal Part of Pons1.52 ± 0.69
Cerebellar Cortex1.65 ± 0.96
Cerebellar Nuclei2.08 ± 0.69
Claustrum2.71 ± 0.99
Epithalamus1.39 ± 0.81
Frontal Lobe1.67 ± 0.9
Globus Pallidus2.48 ± 0.54
Hypothalamus1.85 ± 0.79
Insula1.45 ± 0.52
Limbic Lobe1.81 ± 0.87
Mesencephalon1.95 ± 0.8
Myelencephalon1.81 ± 0.8
Occipital Lobe1.79 ± 0.78
Parietal Lobe1.88 ± 0.85
Pontine Tegmentum1.86 ± 0.72
Striatum1.93 ± 0.6
Subthalamus2.13 ± 0.38
Temporal Lobe1.7 ± 0.91
Thalamus1.71 ± 0.64
White Matter2.13 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dab2CBCerebellum31.2
39.72
Dab2CTXCerebral cortex32.23
23.72
Dab2HIPHippocampal region24.56
29.47
Dab2HPFHippocampal formation27.9
29.76
Dab2HYHypothalamus6.82
6.9
Dab2LSXLateral septal complex9
7.23
Dab2MBMidbrain15.82
17.97
Dab2MYMedulla19.38
24.28
Dab2OLFOlfactory bulb39.06
32.7
Dab2PPons14.4
16.07
Dab2PALPallidum6.28
5.96
Dab2RHPRetrohippocampal region33.13
29.78
Dab2sAMYStriatum-like amygdalar nuclei7.54
8.05
Dab2STRStriatum10.64
9.09
Dab2STRdStriatum dorsal region10.26
9
Dab2STRvStriatum ventral region13.92
10.1
Dab2THThalamus19.86
17.53
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DAB2_HUMAN_208 25 208 232 SGVDQMDLFGDMSTPPDLNSPTESK PRIDE
DAB2_HUMAN_57 8 57 64 IDDVPDAR PRIDE
PAp00159716 11 54 64 LIGIDDVPDAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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