AutismKB 2.0

Annotation Detail for DGKB


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Basic Information Top
Gene Symbol:DGKB ( DAGK2,DGK,DGK-BETA,KIAA0718 )
Gene Full Name: diacylglycerol kinase, beta 90kDa
Band: 7p21.2
Quick LinksEntrez ID:1607; OMIM: 604070; Uniprot ID:DGKB_HUMAN; ENSEMBL ID: ENSG00000136267; HGNC ID: 2850
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult9 / 19391214
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma2 / 10688318
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal56 / 336030716
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain54 / 110098949
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine0 / 2344720 
kidney2 / 2117779
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 216307_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.9
Adipocyte7.85
AdrenalCortex11.7
Adrenalgland7.75
Amygdala35.9
Appendix16.1
AtrioventricularNode12.65
BDCA4+_DentriticCells7.85
Bonemarrow9.15
BronchialEpithelialCells8.45
CD105+_Endothelial9.2
CD14+_Monocytes9
CD19+_BCells(neg._sel.)8.8
CD33+_Myeloid10.15
CD34+10.55
CD4+_Tcells8.9
CD56+_NKCells9.1
CD71+_EarlyErythroid8.4
CD8+_Tcells7.3
CardiacMyocytes19.25
Caudatenucleus80
Cerebellum7.05
CerebellumPeduncles10.9
CiliaryGanglion20.85
CingulateCortex10.1
Colorectaladenocarcinoma8.85
DorsalRootGanglion13.3
FetalThyroid9.3
Fetalbrain8.25
Fetalliver7.85
Fetallung6.05
GlobusPallidus10
Heart28.15
Hypothalamus9.05
Kidney7.95
Leukemia_chronicMyelogenousK-5627.7
Leukemia_promyelocytic-HL-607.35
Leukemialymphoblastic(MOLT-4)6.55
Liver14.6
Lung9.45
Lymphnode6.75
Lymphoma_burkitts(Daudi)11.4
Lymphoma_burkitts(Raji)14
MedullaOblongata27.05
OccipitalLobe15.6
OlfactoryBulb6.8
Ovary7.75
Pancreas8.2
PancreaticIslet9.4
ParietalLobe12.4
Pituitary10.05
Placenta8.15
Pons38.4
PrefrontalCortex28.95
Prostate9.15
Salivarygland7.55
SkeletalMuscle15.85
Skin9.75
SmoothMuscle9.75
Spinalcord9.5
SubthalamicNucleus12
SuperiorCervicalGanglion21.05
TemporalLobe10.1
Testis7.2
TestisGermCell6.9
TestisIntersitial7.65
TestisLeydigCell10.3
TestisSeminiferousTubule7.45
Thalamus11.75
Thymus5.95
Thyroid9.85
Tongue12.45
Tonsil8.7
Trachea7.15
TrigeminalGanglion16.35
Uterus7.1
UterusCorpus9.8
WholeBlood9.5
Wholebrain8
colon8.9
pineal_day19.3
pineal_night10.56
retina16.9
small_intestine8.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P61919
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.04 ± 0.58
Basal Forebrain7.41 ± 0.64
Basal Part of Pons7.9 ± 0.32
Cerebellar Cortex6.5 ± 0.24
Cerebellar Nuclei5.77 ± 0.54
Claustrum6.59 ± 1.24
Epithalamus7.34 ± 0.59
Frontal Lobe7.59 ± 0.63
Globus Pallidus6.31 ± 1.09
Hypothalamus7.89 ± 0.41
Insula7.74 ± 0.32
Limbic Lobe7.67 ± 1.07
Mesencephalon7.03 ± 0.74
Myelencephalon7.39 ± 0.94
Occipital Lobe6.4 ± 1.29
Parietal Lobe7.41 ± 0.74
Pontine Tegmentum7.23 ± 0.94
Striatum9.22 ± 0.58
Subthalamus6.99 ± 0.42
Temporal Lobe7.78 ± 0.59
Thalamus6.64 ± 0.68
White Matter4.24 ± 0.97
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
DgkbCBCerebellum14.04
20.66
DgkbCTXCerebral cortex56.81
66.03
DgkbHIPHippocampal region61.85
66.74
DgkbHPFHippocampal formation53.42
66.73
DgkbHYHypothalamus35.32
35.05
DgkbLSXLateral septal complex66.69
66.68
DgkbMBMidbrain30.73
29.39
DgkbMYMedulla23.17
24.62
DgkbOLFOlfactory bulb66.56
66.77
DgkbPPons22.39
22.33
DgkbPALPallidum34.69
41.03
DgkbRHPRetrohippocampal region42.54
56.15
DgkbsAMYStriatum-like amygdalar nuclei56.83
58.06
DgkbSTRStriatum66.86
66.97
DgkbSTRdStriatum dorsal region66.74
66.81
DgkbSTRvStriatum ventral region66.69
66.7
DgkbTHThalamus12.87
13.17
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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