AutismKB 2.0

Annotation Detail for DAPK1


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Basic Information Top
Gene Symbol:DAPK1 ( DAPK,DKFZp781I035 )
Gene Full Name: death-associated protein kinase 1
Band: 9q21.33
Quick LinksEntrez ID:1612; OMIM: 600831; Uniprot ID:DAPK1_HUMAN; ENSEMBL ID: ENSG00000196730; HGNC ID: 2674
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst13 / 62319208
fetus35 / 56401262
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult101 / 193912152
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor12 / 26384545
glioma3 / 10688328
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor7 / 9635972
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal157 / 336030746
ovarian tumor2 / 7668226
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor2 / 12494916
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone1 / 7165513
bone marrow0 / 488010 
brain29 / 110098926
cervix0 / 481710 
connective tissue10 / 14925566
ear0 / 162120 
embryonic tissue17 / 21572278
esophagus0 / 202090 
eye9 / 21105442
heart4 / 8962644
intestine1 / 2344724
kidney3 / 21177714
larynx0 / 241450 
liver10 / 20774348
lung16 / 33697447
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth1 / 6705214
muscle9 / 10771583
nerve0 / 157680 
ovary3 / 10205129
pancreas10 / 21481246
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta51 / 280825181
prostate0 / 1893450 
salivary gland0 / 201550 
skin5 / 21057423
spleen0 / 539520 
stomach3 / 9661931
testis5 / 33044215
thymus7 / 8113186
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus7 / 23287830
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211214_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.9
Adipocyte7.95
AdrenalCortex10.45
Adrenalgland7.5
Amygdala7.85
Appendix10.15
AtrioventricularNode9.15
BDCA4+_DentriticCells8.3
Bonemarrow9.1
BronchialEpithelialCells7.7
CD105+_Endothelial7.6
CD14+_Monocytes8.45
CD19+_BCells(neg._sel.)7.85
CD33+_Myeloid10.1
CD34+9
CD4+_Tcells7.6
CD56+_NKCells8.9
CD71+_EarlyErythroid7.5
CD8+_Tcells6.7
CardiacMyocytes11.7
Caudatenucleus7.05
Cerebellum6.6
CerebellumPeduncles9.6
CiliaryGanglion7
CingulateCortex8.2
Colorectaladenocarcinoma7.9
DorsalRootGanglion6.85
FetalThyroid8.6
Fetalbrain7.7
Fetalliver7.3
Fetallung6.1
GlobusPallidus7.05
Heart13.35
Hypothalamus7.85
Kidney7
Leukemia_chronicMyelogenousK-5627.2
Leukemia_promyelocytic-HL-607
Leukemialymphoblastic(MOLT-4)6.7
Liver11.9
Lung14.25
Lymphnode7.35
Lymphoma_burkitts(Daudi)10.6
Lymphoma_burkitts(Raji)11.4
MedullaOblongata7.15
OccipitalLobe6.95
OlfactoryBulb6.15
Ovary6.15
Pancreas6.75
PancreaticIslet8.9
ParietalLobe9.3
Pituitary9.5
Placenta34.05
Pons7.95
PrefrontalCortex9.2
Prostate8.7
Salivarygland6.6
SkeletalMuscle11.15
Skin7.4
SmoothMuscle8.85
Spinalcord8.25
SubthalamicNucleus7.7
SuperiorCervicalGanglion12.5
TemporalLobe7.95
Testis7.55
TestisGermCell6
TestisIntersitial6.8
TestisLeydigCell8.45
TestisSeminiferousTubule6.8
Thalamus8.1
Thymus6.35
Thyroid9.65
Tongue12.25
Tonsil7.75
Trachea6.5
TrigeminalGanglion9.55
Uterus6
UterusCorpus7.35
WholeBlood8.65
Wholebrain6.75
colon7.75
pineal_day9.14
pineal_night9.02
retina9.2
small_intestine7.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P393449
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.75 ± 0.48
Basal Forebrain7.89 ± 0.35
Basal Part of Pons6.57 ± 0.49
Cerebellar Cortex6.81 ± 0.32
Cerebellar Nuclei5.83 ± 0.59
Claustrum6.45 ± 0.68
Epithalamus8.17 ± 0.87
Frontal Lobe7.67 ± 0.57
Globus Pallidus6.8 ± 0.85
Hypothalamus7.69 ± 0.43
Insula7.83 ± 0.43
Limbic Lobe7.93 ± 0.7
Mesencephalon7.23 ± 0.67
Myelencephalon7.55 ± 0.77
Occipital Lobe7.13 ± 0.66
Parietal Lobe7.79 ± 0.65
Pontine Tegmentum7.76 ± 0.77
Striatum8.24 ± 0.72
Subthalamus7.03 ± 0.31
Temporal Lobe7.69 ± 0.55
Thalamus7.2 ± 0.47
White Matter5.39 ± 0.47
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dapk1CBCerebellum3.58
4.43
Dapk1CTXCerebral cortex63.07
49.79
Dapk1HIPHippocampal region85.69
100
Dapk1HPFHippocampal formation81.62
100
Dapk1HYHypothalamus11.84
10.41
Dapk1LSXLateral septal complex73.38
68.7
Dapk1MBMidbrain12.98
11.84
Dapk1MYMedulla12.46
14.27
Dapk1OLFOlfactory bulb69.89
62.27
Dapk1PPons10.1
10.71
Dapk1PALPallidum20.03
18.77
Dapk1RHPRetrohippocampal region73.79
69.56
Dapk1sAMYStriatum-like amygdalar nuclei32.13
24.98
Dapk1STRStriatum47.37
35.96
Dapk1STRdStriatum dorsal region44.47
33.2
Dapk1STRvStriatum ventral region54.2
39.21
Dapk1THThalamus52.61
50.25
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00029542 19 477 495 EEETPLHCAAWHGYYSVAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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