AutismKB 2.0

Annotation Detail for C14orf21


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:C14orf21 ( KIAA2021 )
Gene Full Name: chromosome 14 open reading frame 21
Band: 14q12
Quick LinksEntrez ID:161424; OMIM: NA; Uniprot ID:CN021_HUMAN; ENSEMBL ID: ENSG00000196943; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst6 / 6231996
fetus10 / 56401217
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult63 / 193912132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor2 / 3436658
chondrosarcoma1 / 8282312
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor4 / 26384515
glioma4 / 10688337
head and neck tumor9 / 13630266
kidney tumor8 / 68959116
leukemia3 / 9584231
liver tumor3 / 9635931
lung tumor10 / 10312796
lymphoma9 / 71755125
non-neoplasia1 / 9725010
normal86 / 336030725
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer6 / 10268058
retinoblastoma1 / 4635621
skin tumor12 / 12494996
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder1 / 2975733
blood2 / 12347816
bone2 / 7165527
bone marrow1 / 4880120
brain16 / 110098914
cervix10 / 48171207
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye10 / 21105447
heart0 / 896260 
intestine10 / 23447242
kidney9 / 21177742
larynx2 / 2414582
liver3 / 20774314
lung17 / 33697450
lymph4 / 4427090
lymph node7 / 9161076
mammary gland4 / 15327126
mouth6 / 6705289
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta7 / 28082524
prostate7 / 18934536
salivary gland0 / 201550 
skin14 / 21057466
spleen1 / 5395218
stomach4 / 9661941
testis9 / 33044227
thymus3 / 8113136
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220130_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.6
Adipocyte5.55
AdrenalCortex5.95
Adrenalgland4.75
Amygdala5.65
Appendix5.55
AtrioventricularNode4.3
BDCA4+_DentriticCells5.85
Bonemarrow7.15
BronchialEpithelialCells5.3
CD105+_Endothelial5.7
CD14+_Monocytes6
CD19+_BCells(neg._sel.)6
CD33+_Myeloid7.2
CD34+7.1
CD4+_Tcells6.1
CD56+_NKCells6.65
CD71+_EarlyErythroid5.3
CD8+_Tcells5.35
CardiacMyocytes6.95
Caudatenucleus6.2
Cerebellum4.55
CerebellumPeduncles6.4
CiliaryGanglion6.6
CingulateCortex6.15
Colorectaladenocarcinoma5.65
DorsalRootGanglion4.4
FetalThyroid5.45
Fetalbrain5.65
Fetalliver4.85
Fetallung4.4
GlobusPallidus4.15
Heart7.05
Hypothalamus6.1
Kidney6.3
Leukemia_chronicMyelogenousK-5625.1
Leukemia_promyelocytic-HL-604.95
Leukemialymphoblastic(MOLT-4)4.55
Liver7.4
Lung6.15
Lymphnode4.85
Lymphoma_burkitts(Daudi)7.15
Lymphoma_burkitts(Raji)7.8
MedullaOblongata5.9
OccipitalLobe6.35
OlfactoryBulb4.45
Ovary3.65
Pancreas4.5
PancreaticIslet6
ParietalLobe5.95
Pituitary6.6
Placenta5.85
Pons5.85
PrefrontalCortex7
Prostate6.3
Salivarygland4.5
SkeletalMuscle6.65
Skin4.45
SmoothMuscle6.4
Spinalcord6.05
SubthalamicNucleus6.5
SuperiorCervicalGanglion6.7
TemporalLobe10.65
Testis4.8
TestisGermCell4.4
TestisIntersitial4.65
TestisLeydigCell5.55
TestisSeminiferousTubule4.85
Thalamus9.5
Thymus4.15
Thyroid6.9
Tongue6.1
Tonsil6.6
Trachea6.85
TrigeminalGanglion5.65
Uterus4.35
UterusCorpus5.05
WholeBlood6.1
Wholebrain4.7
colon5.65
pineal_day6.74
pineal_night6.68
retina7.8
small_intestine5.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10202_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.46 ± 1.03
Basal Forebrain2.06 ± 0.24
Basal Part of Pons1.71 ± 0.29
Cerebellar Cortex1.94 ± 0.74
Cerebellar Nuclei2.37 ± 0.74
Claustrum2.87 ± 0.84
Epithalamus1.72 ± 0.79
Frontal Lobe1.87 ± 0.6
Globus Pallidus2.54 ± 0.44
Hypothalamus2.07 ± 0.61
Insula1.84 ± 0.45
Limbic Lobe2.01 ± 0.6
Mesencephalon2.11 ± 0.61
Myelencephalon2.05 ± 0.66
Occipital Lobe2.05 ± 0.48
Parietal Lobe2.01 ± 0.65
Pontine Tegmentum2.14 ± 0.84
Striatum2.13 ± 0.55
Subthalamus2.2 ± 0.71
Temporal Lobe1.94 ± 0.77
Thalamus1.99 ± 0.57
White Matter2.43 ± 0.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
2610027L16RikCBCerebellum4.55
5.23
2610027L16RikCTXCerebral cortex0.69
0.61
2610027L16RikHIPHippocampal region1.44
1.09
2610027L16RikHPFHippocampal formation1.17
0.84
2610027L16RikHYHypothalamus3.04
2.15
2610027L16RikLSXLateral septal complex0.84
0.74
2610027L16RikMBMidbrain1.4
1.42
2610027L16RikMYMedulla9.19
9.9
2610027L16RikOLFOlfactory bulb4.88
4.17
2610027L16RikPPons8.04
7.93
2610027L16RikPALPallidum1.2
1.13
2610027L16RikRHPRetrohippocampal region0.44
0.38
2610027L16RiksAMYStriatum-like amygdalar nuclei0.74
0.49
2610027L16RikSTRStriatum0.92
0.72
2610027L16RikSTRdStriatum dorsal region0.23
0.34
2610027L16RikSTRvStriatum ventral region3.35
2.01
2610027L16RikTHThalamus0.58
0.4
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001039 15 141 155 CGVHVLQSALLQLPR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018