AutismKB 2.0

Annotation Detail for DARS


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DARS ( DKFZp781B11202,MGC111579 )
Gene Full Name: aspartyl-tRNA synthetase
Band: 2q21.3
Quick LinksEntrez ID:1615; OMIM: 603084; Uniprot ID:SYDC_HUMAN; ENSEMBL ID: ENSG00000115866; HGNC ID: 2678
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst4 / 6231964
fetus63 / 564012111
neonate2 / 3109764
infant4 / 23620169
juvenile9 / 55556161
adult198 / 1939121102
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma1 / 1747557
breast (mammary gland) tumor7 / 9417874
cervical tumor5 / 34366145
chondrosarcoma10 / 82823120
colorectal tumor19 / 114246166
esophageal tumor7 / 17290404
gastrointestinal tumor12 / 119369100
germ cell tumor28 / 263845106
glioma4 / 10688337
head and neck tumor13 / 13630295
kidney tumor9 / 68959130
leukemia9 / 9584293
liver tumor24 / 96359249
lung tumor6 / 10312758
lymphoma11 / 71755153
non-neoplasia12 / 97250123
normal329 / 336030797
ovarian tumor13 / 76682169
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS17 / 125680135
prostate cancer7 / 10268068
retinoblastoma6 / 46356129
skin tumor11 / 12494988
soft tissue/muscle tissue tumor16 / 125191127
uterine tumor12 / 90257132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland5 / 33197150
ascites4 / 4001599
bladder5 / 29757168
blood15 / 123478121
bone12 / 71655167
bone marrow5 / 48801102
brain117 / 1100989106
cervix5 / 48171103
connective tissue18 / 149255120
ear0 / 162120 
embryonic tissue23 / 215722106
esophagus7 / 20209346
eye21 / 21105499
heart14 / 89626156
intestine23 / 23447298
kidney21 / 21177799
larynx1 / 2414541
liver39 / 207743187
lung24 / 33697471
lymph4 / 4427090
lymph node6 / 9161065
mammary gland14 / 15327191
mouth6 / 6705289
muscle13 / 107715120
nerve1 / 1576863
ovary15 / 102051146
pancreas24 / 214812111
parathyroid0 / 205390 
pharynx11 / 41328266
pituitary gland4 / 16585241
placenta44 / 280825156
prostate15 / 18934579
salivary gland2 / 2015599
skin18 / 21057485
spleen2 / 5395237
stomach7 / 9661972
testis27 / 33044281
thymus13 / 81131160
thyroid6 / 47473126
tonsil3 / 16999176
trachea2 / 5241338
umbilical cord2 / 13680146
uterus28 / 232878120
vascular15 / 51780289
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201623_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts1489.15
Adipocyte170.7
AdrenalCortex170.2
Adrenalgland22
Amygdala152.55
Appendix117.8
AtrioventricularNode14.15
BDCA4+_DentriticCells489.9
Bonemarrow23.65
BronchialEpithelialCells517.55
CD105+_Endothelial521.1
CD14+_Monocytes263.05
CD19+_BCells(neg._sel.)837.95
CD33+_Myeloid474.5
CD34+907.4
CD4+_Tcells500
CD56+_NKCells361.7
CD71+_EarlyErythroid73
CD8+_Tcells417.55
CardiacMyocytes373.4
Caudatenucleus79.35
Cerebellum12.9
CerebellumPeduncles74.1
CiliaryGanglion53.45
CingulateCortex183.8
Colorectaladenocarcinoma355.35
DorsalRootGanglion57.8
FetalThyroid320.9
Fetalbrain49.75
Fetalliver148.95
Fetallung107.45
GlobusPallidus87.9
Heart22.05
Hypothalamus379.1
Kidney52.15
Leukemia_chronicMyelogenousK-562335
Leukemia_promyelocytic-HL-60156.75
Leukemialymphoblastic(MOLT-4)213.35
Liver23.25
Lung27.8
Lymphnode98.5
Lymphoma_burkitts(Daudi)344.4
Lymphoma_burkitts(Raji)661.05
MedullaOblongata152.8
OccipitalLobe162
OlfactoryBulb260.1
Ovary223.8
Pancreas436.45
PancreaticIslet522.55
ParietalLobe118.6
Pituitary29.4
Placenta212.75
Pons92.65
PrefrontalCortex63.3
Prostate60.8
Salivarygland25.1
SkeletalMuscle82.5
Skin81.15
SmoothMuscle477.95
Spinalcord122.1
SubthalamicNucleus30.9
SuperiorCervicalGanglion78.25
TemporalLobe50.45
Testis28.75
TestisGermCell174.75
TestisIntersitial64.9
TestisLeydigCell87
TestisSeminiferousTubule91.3
Thalamus34.1
Thymus164.25
Thyroid248.75
Tongue187.35
Tonsil346
Trachea117.45
TrigeminalGanglion57
Uterus55.25
UterusCorpus126.7
WholeBlood39.55
Wholebrain24.45
colon235.45
pineal_day627.64
pineal_night515.74
retina434.15
small_intestine190.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P108415
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.37 ± 0.15
Basal Forebrain10.53 ± 0.17
Basal Part of Pons10.03 ± 0.16
Cerebellar Cortex10.23 ± 0.13
Cerebellar Nuclei10.2 ± 0.15
Claustrum10.17 ± 0.28
Epithalamus10.79 ± 0.16
Frontal Lobe10.39 ± 0.25
Globus Pallidus11.14 ± 0.2
Hypothalamus10.6 ± 0.18
Insula10.28 ± 0.15
Limbic Lobe10.28 ± 0.27
Mesencephalon10.49 ± 0.22
Myelencephalon10.44 ± 0.25
Occipital Lobe10.36 ± 0.2
Parietal Lobe10.37 ± 0.24
Pontine Tegmentum10.44 ± 0.26
Striatum10.85 ± 0.2
Subthalamus10.23 ± 0.12
Temporal Lobe10.32 ± 0.18
Thalamus10.51 ± 0.16
White Matter10.43 ± 0.15
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
DarsCBCerebellum21.92
37.45
DarsCTXCerebral cortex24.93
19.29
DarsHIPHippocampal region39.29
53.62
DarsHPFHippocampal formation38.31
43.42
DarsHYHypothalamus7.22
5.88
DarsLSXLateral septal complex9.8
7.78
DarsMBMidbrain10.72
10.37
DarsMYMedulla17.69
21.17
DarsOLFOlfactory bulb23.61
19.14
DarsPPons15.09
17.09
DarsPALPallidum10.48
10.48
DarsRHPRetrohippocampal region37.25
29.62
DarssAMYStriatum-like amygdalar nuclei11.93
8.76
DarsSTRStriatum10.56
8.06
DarsSTRdStriatum dorsal region10.25
8.07
DarsSTRvStriatum ventral region11.76
8.03
DarsTHThalamus14.02
12.82
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002220 17 27 43 ERYGISSMIQSQEKPDR Peptide Atlas
SYDC_HUMAN_126 15 126 140 IGSCTQQDVELHVQK PRIDE
SYDC_HUMAN_141 10 141 150 IYVISLAEPR PRIDE
SYDC_HUMAN_151 20 151 170 LPLQLDDAVRPEAEGEEEGR PRIDE
SYDC_HUMAN_254 10 254 263 QMCICADFEK PRIDE
SYDC_HUMAN_29 15 29 43 YGISSMIQSQEKPDR PRIDE
SYDC_HUMAN_345 11 345 355 LEYCEALAMLR PRIDE
SYDC_HUMAN_394 15 394 408 YPLAVRPFYTMPDPR PRIDE
SYDC_HUMAN_400 9 400 408 PFYTMPDPR PRIDE
SYDC_HUMAN_412 10 412 421 QSNSYDMFMR PRIDE
SYDC_HUMAN_460 15 460 474 FGAPPHAGGGIGLER PRIDE
SYDC_HUMAN_475 12 475 486 VTMLFLGLHNVR PRIDE
SYDC_HUMAN_476 12 476 487 VTMLFLGLHNVR PRIDE
SYDC_HUMAN_488 7 488 494 QTSMFPR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved