AutismKB 2.0

Annotation Detail for SPRED1


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Basic Information Top
Gene Symbol:SPRED1 ( FLJ33903,NFLS )
Gene Full Name: sprouty-related, EVH1 domain containing 1
Band: 15q14
Quick LinksEntrez ID:161742; OMIM: 609291; Uniprot ID:SPRE1_HUMAN; ENSEMBL ID: ENSG00000166068; HGNC ID: 20249
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst3 / 6231948
fetus24 / 56401242
neonate5 / 31097160
infant0 / 236200 
juvenile2 / 5555635
adult48 / 193912124
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor11 / 11424696
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor7 / 26384526
glioma4 / 10688337
head and neck tumor9 / 13630266
kidney tumor3 / 6895943
leukemia4 / 9584241
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal102 / 336030730
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder1 / 2975733
blood4 / 12347832
bone0 / 716550 
bone marrow0 / 488010 
brain40 / 110098936
cervix1 / 4817120
connective tissue4 / 14925526
ear3 / 16212185
embryonic tissue14 / 21572264
esophagus1 / 2020949
eye0 / 2110540 
heart1 / 8962611
intestine11 / 23447246
kidney9 / 21177742
larynx1 / 2414541
liver4 / 20774319
lung6 / 33697417
lymph0 / 442700 
lymph node0 / 916100 
mammary gland4 / 15327126
mouth3 / 6705244
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta7 / 28082524
prostate2 / 18934510
salivary gland0 / 201550 
skin7 / 21057433
spleen2 / 5395237
stomach1 / 9661910
testis5 / 33044215
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus11 / 23287847
vascular2 / 5178038
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P54460
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.01 ± 0.32
Basal Forebrain7.19 ± 0.35
Basal Part of Pons6.47 ± 0.5
Cerebellar Cortex6.45 ± 0.5
Cerebellar Nuclei6.92 ± 0.27
Claustrum6.56 ± 0.73
Epithalamus6.44 ± 0.58
Frontal Lobe6.93 ± 0.37
Globus Pallidus7.04 ± 0.36
Hypothalamus6.47 ± 0.46
Insula7.09 ± 0.23
Limbic Lobe6.89 ± 0.46
Mesencephalon6.9 ± 0.51
Myelencephalon6.86 ± 0.53
Occipital Lobe6.56 ± 0.4
Parietal Lobe6.79 ± 0.46
Pontine Tegmentum7 ± 0.42
Striatum7.4 ± 0.32
Subthalamus6.82 ± 0.1
Temporal Lobe7.12 ± 0.46
Thalamus6.92 ± 0.54
White Matter7.33 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Spred1CBCerebellum31.69
36.64
Spred1CTXCerebral cortex100
100
Spred1HIPHippocampal region44.28
66.05
Spred1HPFHippocampal formation63.77
73.97
Spred1HYHypothalamus42.85
34.53
Spred1LSXLateral septal complex53
42.46
Spred1MBMidbrain60.92
51.97
Spred1MYMedulla41.07
39.39
Spred1OLFOlfactory bulb91.98
95.93
Spred1PPons44.82
44.05
Spred1PALPallidum42.53
35.45
Spred1RHPRetrohippocampal region88.14
81.09
Spred1sAMYStriatum-like amygdalar nuclei71.83
56.52
Spred1STRStriatum100
100
Spred1STRdStriatum dorsal region100
100
Spred1STRvStriatum ventral region100
92.95
Spred1THThalamus30.79
25.42
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
SPRE1_HUMAN_2 15 2 16 SEETATSDNDNSYAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018