Annotation Detail for DCX
Basic Information Top
| Gene Symbol: | DCX ( DBCN,DC,FLJ51296,LISX,SCLH,XLIS ) |
|---|---|
| Gene Full Name: | doublecortin |
| Band: | Xq23 |
| Quick Links | Entrez ID:1641; OMIM: 300121; Uniprot ID:DCX_HUMAN; ENSEMBL ID: ENSG00000077279; HGNC ID: 2714 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.34780
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 1 / 70761 | 14 |  |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 255 / 564012 | 452 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 1 / 23620 | 42 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 59 / 1939121 | 30 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 0 / 82823 | 0 | |
| colorectal tumor | 0 / 114246 | 0 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 0 / 119369 | 0 | |
| germ cell tumor | 49 / 263845 | 185 |  |
| glioma | 5 / 106883 | 46 | |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 0 / 95842 | 0 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 5 / 103127 | 48 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 0 / 97250 | 0 | |
| normal | 284 / 3360307 | 84 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 2 / 125680 | 15 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 0 / 90257 | 0 |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 0 / 123478 | 0 | |
| bone | 0 / 71655 | 0 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 250 / 1100989 | 227 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 0 / 149255 | 0 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 3 / 215722 | 13 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 9 / 211054 | 42 | |
| heart | 0 / 89626 | 0 | |
| intestine | 0 / 234472 | 0 | |
| kidney | 0 / 211777 | 0 | |
| larynx | 0 / 24145 | 0 | |
| liver | 0 / 207743 | 0 | |
| lung | 13 / 336974 | 38 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 0 / 153271 | 0 | |
| mouth | 2 / 67052 | 29 | |
| muscle | 4 / 107715 | 37 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 0 / 214812 | 0 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 3 / 280825 | 10 |  |
| prostate | 0 / 189345 | 0 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 0 / 210574 | 0 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 0 / 96619 | 0 | |
| testis | 11 / 330442 | 33 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 0 / 232878 | 0 | |
| vascular | 2 / 51780 | 38 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 204850_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 7.3 | |
| Adipocyte | 6.45 | |
| AdrenalCortex | 7.95 | |
| Adrenalgland | 5.9 | |
| Amygdala | 16.8 | |
| Appendix | 7.45 | |
| AtrioventricularNode | 5.95 | |
| BDCA4+_DentriticCells | 6.6 | |
| Bonemarrow | 7 | |
| BronchialEpithelialCells | 6.2 | |
| CD105+_Endothelial | 6.45 | |
| CD14+_Monocytes | 6.85 | |
| CD19+_BCells(neg._sel.) | 6.75 | |
| CD33+_Myeloid | 8.05 | |
| CD34+ | 7.8 | |
| CD4+_Tcells | 6.8 | |
| CD56+_NKCells | 7.45 | |
| CD71+_EarlyErythroid | 5.95 | |
| CD8+_Tcells | 5.95 | |
| CardiacMyocytes | 9.75 | |
| Caudatenucleus | 9.2 | |
| Cerebellum | 5.45 | |
| CerebellumPeduncles | 7.95 | |
| CiliaryGanglion | 5.45 | |
| CingulateCortex | 9.25 | |
| Colorectaladenocarcinoma | 6.5 | |
| DorsalRootGanglion | 5.65 | |
| FetalThyroid | 6.3 | |
| Fetalbrain | 2577 |  |
| Fetalliver | 5.9 | |
| Fetallung | 5.15 | |
| GlobusPallidus | 5.2 | |
| Heart | 9.95 | |
| Hypothalamus | 12.55 | |
| Kidney | 5.7 | |
| Leukemia_chronicMyelogenousK-562 | 5.9 | |
| Leukemia_promyelocytic-HL-60 | 5.85 | |
| Leukemialymphoblastic(MOLT-4) | 5.1 | |
| Liver | 9.7 | |
| Lung | 7 | |
| Lymphnode | 5.4 | |
| Lymphoma_burkitts(Daudi) | 8.5 | |
| Lymphoma_burkitts(Raji) | 9.7 | |
| MedullaOblongata | 7.8 | |
| OccipitalLobe | 6 | |
| OlfactoryBulb | 5.15 | |
| Ovary | 4.7 | |
| Pancreas | 5.2 | |
| PancreaticIslet | 7.05 | |
| ParietalLobe | 13.55 | |
| Pituitary | 7.6 | |
| Placenta | 6.55 | |
| Pons | 6.65 | |
| PrefrontalCortex | 17.2 | |
| Prostate | 7.3 | |
| Salivarygland | 5.55 | |
| SkeletalMuscle | 9.15 | |
| Skin | 5.6 | |
| SmoothMuscle | 7.3 | |
| Spinalcord | 11.75 | |
| SubthalamicNucleus | 6.3 | |
| SuperiorCervicalGanglion | 9.4 | |
| TemporalLobe | 6.4 | |
| Testis | 5.7 | |
| TestisGermCell | 5.25 | |
| TestisIntersitial | 5.5 | |
| TestisLeydigCell | 6.95 | |
| TestisSeminiferousTubule | 5.65 | |
| Thalamus | 7.7 | |
| Thymus | 5 | |
| Thyroid | 8.05 | |
| Tongue | 7.1 | |
| Tonsil | 6.5 | |
| Trachea | 5.4 | |
| TrigeminalGanglion | 7.45 | |
| Uterus | 5.35 | |
| UterusCorpus | 16.35 | |
| WholeBlood | 7.05 | |
| Wholebrain | 10.55 | |
| colon | 6.75 | |
| pineal_day | 7.94 | |
| pineal_night | 7.92 | |
| retina | 10.05 | |
| small_intestine | 6.35 | |
- Probe name: CUST_12179_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 4.75 ± 0.76 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 4.24 ± 0.55 | |
| Basal Part of Pons | 4.09 ± 0.57 | |
| Cerebellar Cortex | 3.09 ± 0.43 | |
| Cerebellar Nuclei | 3.53 ± 0.49 | |
| Claustrum | 4.15 ± 0.87 | |
| Epithalamus | 3.29 ± 0.65 | |
| Frontal Lobe | 3.79 ± 0.61 | |
| Globus Pallidus | 3.37 ± 1.07 | |
| Hypothalamus | 4.55 ± 0.34 | |
| Insula | 4.1 ± 0.33 | |
| Limbic Lobe | 3.81 ± 0.6 | |
| Mesencephalon | 4.05 ± 0.69 | |
| Myelencephalon | 3.85 ± 0.67 | |
| Occipital Lobe | 3.76 ± 0.52 | |
| Parietal Lobe | 3.81 ± 0.65 | |
| Pontine Tegmentum | 3.64 ± 0.68 | |
| Striatum | 4.79 ± 0.43 | |
| Subthalamus | 3.43 ± 0.26 | |
| Temporal Lobe | 3.98 ± 0.47 | |
| Thalamus | 3.51 ± 0.61 | |
| White Matter | 2.3 ± 1.12 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Dcx | CB | Cerebellum | 2.62 | |
| 3.57 | | |||
| Dcx | CTX | Cerebral cortex | 4.9 | |
| 5.18 | | |||
| Dcx | HIP | Hippocampal region | 3.98 | |
| 5.08 | | |||
| Dcx | HPF | Hippocampal formation | 3.24 | |
| 3.83 | | |||
| Dcx | HY | Hypothalamus | 2.25 | |
| 1.69 | | |||
| Dcx | LSX | Lateral septal complex | 2.97 | |
| 4.1 | | |||
| Dcx | MB | Midbrain | 1.8 | |
| 2.42 | | |||
| Dcx | MY | Medulla | 6.14 | |
| 7.23 | | |||
| Dcx | OLF | Olfactory bulb | 24.82 | |
| 26.05 | | |||
| Dcx | P | Pons | 1.79 | |
| 1.67 | | |||
| Dcx | PAL | Pallidum | 0.99 | |
| 0.85 | | |||
| Dcx | RHP | Retrohippocampal region | 1.63 | |
| 1.7 | | |||
| Dcx | sAMY | Striatum-like amygdalar nuclei | 0.51 | |
| 0.73 | | |||
| Dcx | STR | Striatum | 3.22 | |
| 4.71 | | |||
| Dcx | STRd | Striatum dorsal region | 2.63 | |
| 4.12 | | |||
| Dcx | STRv | Striatum ventral region | 6.41 | |
| 7.69 | | |||
| Dcx | TH | Thalamus | 2.06 | |
| 1.88 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| DCX_HUMAN_43 | 11 | 43 | 53 | MELDFGHFDER | PRIDE |