AutismKB 2.0

Annotation Detail for DDB2


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Basic Information Top
Gene Symbol:DDB2 ( DDBB,FLJ34321,UV-DDB2 )
Gene Full Name: damage-specific DNA binding protein 2, 48kDa
Band: 11p11.2
Quick LinksEntrez ID:1643; OMIM: 600811; Uniprot ID:DDB2_HUMAN; ENSEMBL ID: ENSG00000134574; HGNC ID: 2718
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst7 / 62319112
fetus35 / 56401262
neonate3 / 3109796
infant0 / 236200 
juvenile3 / 5555653
adult89 / 193912145
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor7 / 34366203
chondrosarcoma9 / 82823108
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor16 / 119369134
germ cell tumor12 / 26384545
glioma9 / 10688384
head and neck tumor7 / 13630251
kidney tumor2 / 6895929
leukemia12 / 95842125
liver tumor6 / 9635962
lung tumor11 / 103127106
lymphoma9 / 71755125
non-neoplasia7 / 9725071
normal143 / 336030742
ovarian tumor2 / 7668226
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer5 / 10268048
retinoblastoma4 / 4635686
skin tumor5 / 12494940
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites6 / 40015149
bladder0 / 297570 
blood7 / 12347856
bone3 / 7165541
bone marrow1 / 4880120
brain31 / 110098928
cervix12 / 48171249
connective tissue16 / 149255107
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus1 / 2020949
eye10 / 21105447
heart2 / 8962622
intestine12 / 23447251
kidney11 / 21177751
larynx1 / 2414541
liver13 / 20774362
lung24 / 33697471
lymph5 / 44270112
lymph node8 / 9161087
mammary gland2 / 15327113
mouth0 / 670520 
muscle4 / 10771537
nerve0 / 157680 
ovary3 / 10205129
pancreas7 / 21481232
parathyroid1 / 2053948
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta11 / 28082539
prostate7 / 18934536
salivary gland1 / 2015549
skin7 / 21057433
spleen4 / 5395274
stomach12 / 96619124
testis11 / 33044233
thymus3 / 8113136
thyroid4 / 4747384
tonsil5 / 16999294
trachea0 / 524130 
umbilical cord3 / 13680219
uterus9 / 23287838
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203409_at
Cell line Expression level Expression bar
721_B_lymphoblasts244.35
Adipocyte12.3
AdrenalCortex6.25
Adrenalgland7.6
Amygdala5.6
Appendix5.25
AtrioventricularNode5.25
BDCA4+_DentriticCells11.45
Bonemarrow5.1
BronchialEpithelialCells29.85
CD105+_Endothelial6.95
CD14+_Monocytes5.95
CD19+_BCells(neg._sel.)8.15
CD33+_Myeloid7.45
CD34+11.65
CD4+_Tcells64.05
CD56+_NKCells33.2
CD71+_EarlyErythroid6.85
CD8+_Tcells39.55
CardiacMyocytes6.55
Caudatenucleus4.3
Cerebellum4.5
CerebellumPeduncles5.5
CiliaryGanglion3.6
CingulateCortex5.45
Colorectaladenocarcinoma18.45
DorsalRootGanglion4.1
FetalThyroid4.65
Fetalbrain4.9
Fetalliver4.5
Fetallung4.5
GlobusPallidus3.95
Heart6.2
Hypothalamus4.55
Kidney4.05
Leukemia_chronicMyelogenousK-5624.8
Leukemia_promyelocytic-HL-60178.6
Leukemialymphoblastic(MOLT-4)71.4
Liver6.85
Lung8.6
Lymphnode12
Lymphoma_burkitts(Daudi)87.5
Lymphoma_burkitts(Raji)19.75
MedullaOblongata4.85
OccipitalLobe4.35
OlfactoryBulb12.1
Ovary3.45
Pancreas11
PancreaticIslet9.8
ParietalLobe5.5
Pituitary6.25
Placenta5.5
Pons5.05
PrefrontalCortex6.55
Prostate6.35
Salivarygland4.3
SkeletalMuscle6.2
Skin5.35
SmoothMuscle11.9
Spinalcord6.35
SubthalamicNucleus4.35
SuperiorCervicalGanglion6.4
TemporalLobe4.8
Testis4.55
TestisGermCell4.75
TestisIntersitial3.85
TestisLeydigCell5.2
TestisSeminiferousTubule4.55
Thalamus5.1
Thymus21.8
Thyroid5.25
Tongue5.15
Tonsil7.95
Trachea4.4
TrigeminalGanglion7.25
Uterus5.7
UterusCorpus5.65
WholeBlood5.85
Wholebrain4.6
colon5.3
pineal_day6.48
pineal_night6.52
retina7.825
small_intestine5.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13560_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.67 ± 0.69
Basal Forebrain3.65 ± 0.68
Basal Part of Pons3.79 ± 0.59
Cerebellar Cortex4.25 ± 0.28
Cerebellar Nuclei3.48 ± 0.59
Claustrum3.74 ± 1.01
Epithalamus4.15 ± 0.59
Frontal Lobe3.94 ± 0.52
Globus Pallidus3.29 ± 0.31
Hypothalamus3.44 ± 0.64
Insula3.81 ± 0.46
Limbic Lobe3.66 ± 0.69
Mesencephalon3.71 ± 0.65
Myelencephalon3.74 ± 0.6
Occipital Lobe3.39 ± 0.56
Parietal Lobe3.73 ± 0.61
Pontine Tegmentum3.65 ± 0.69
Striatum2.79 ± 0.65
Subthalamus4.1 ± 0.17
Temporal Lobe3.85 ± 0.55
Thalamus3.53 ± 0.54
White Matter4.19 ± 0.7
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ddb2CBCerebellum0.61
1.28
Ddb2CTXCerebral cortex0.38
0.57
Ddb2HIPHippocampal region0.22
0.35
Ddb2HPFHippocampal formation0.23
0.29
Ddb2HYHypothalamus0.33
0.3
Ddb2LSXLateral septal complex0.13
0.21
Ddb2MBMidbrain0.22
0.48
Ddb2MYMedulla0.29
0.61
Ddb2OLFOlfactory bulb0.38
0.42
Ddb2PPons2.33
3.21
Ddb2PALPallidum0.34
0.57
Ddb2RHPRetrohippocampal region0.27
0.22
Ddb2sAMYStriatum-like amygdalar nuclei0.09
0.07
Ddb2STRStriatum0.27
0.28
Ddb2STRdStriatum dorsal region0.14
0.16
Ddb2STRvStriatum ventral region0.78
0.72
Ddb2THThalamus0.31
0.42
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00096083 14 289 302 HPVNAACFSPDGAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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