AutismKB 2.0

Annotation Detail for DDC


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Basic Information Top
Gene Symbol:DDC ( AADC )
Gene Full Name: dopa decarboxylase (aromatic L-amino acid decarboxylase)
Band: 7p12.2-p12.1
Quick LinksEntrez ID:1644; OMIM: 107930; Uniprot ID:DDC_HUMAN; ENSEMBL ID: ENSG00000132437; HGNC ID: 2719
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus12 / 56401221
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult40 / 193912120
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor2 / 9635920
lung tumor8 / 10312777
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal71 / 336030721
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS11 / 12568087
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain3 / 11009892
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye18 / 21105485
heart0 / 896260 
intestine11 / 23447246
kidney31 / 211777146
larynx0 / 241450 
liver3 / 20774314
lung25 / 33697474
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate3 / 18934515
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis2 / 3304426
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214347_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.2
Adipocyte11.15
AdrenalCortex14.85
Adrenalgland10.05
Amygdala10.7
Appendix12.3
AtrioventricularNode12.15
BDCA4+_DentriticCells9.3
Bonemarrow11.85
BronchialEpithelialCells11.25
CD105+_Endothelial11.25
CD14+_Monocytes11.85
CD19+_BCells(neg._sel.)11.8
CD33+_Myeloid14
CD34+12.7
CD4+_Tcells11.6
CD56+_NKCells10.95
CD71+_EarlyErythroid10.8
CD8+_Tcells10.25
CardiacMyocytes24.05
Caudatenucleus10.3
Cerebellum9.35
CerebellumPeduncles13.45
CiliaryGanglion9.65
CingulateCortex12.85
Colorectaladenocarcinoma11.05
DorsalRootGanglion11.95
FetalThyroid12.2
Fetalbrain10.55
Fetalliver10.25
Fetallung7.9
GlobusPallidus8.8
Heart25.35
Hypothalamus11.9
Kidney60.55
Leukemia_chronicMyelogenousK-56210.4
Leukemia_promyelocytic-HL-6010.15
Leukemialymphoblastic(MOLT-4)8.15
Liver19.95
Lung11.85
Lymphnode8.9
Lymphoma_burkitts(Daudi)15.05
Lymphoma_burkitts(Raji)19.15
MedullaOblongata10.2
OccipitalLobe10.1
OlfactoryBulb8.2
Ovary8.8
Pancreas9.3
PancreaticIslet11.95
ParietalLobe13.25
Pituitary13.65
Placenta10.85
Pons11.15
PrefrontalCortex13.65
Prostate12.6
Salivarygland9.45
SkeletalMuscle20.95
Skin9.4
SmoothMuscle12.85
Spinalcord12.05
SubthalamicNucleus10.8
SuperiorCervicalGanglion15
TemporalLobe10.65
Testis9.75
TestisGermCell9.05
TestisIntersitial10.75
TestisLeydigCell11.75
TestisSeminiferousTubule9.75
Thalamus12.3
Thymus7.85
Thyroid12.5
Tongue12.25
Tonsil11.75
Trachea9.3
TrigeminalGanglion15.3
Uterus8.8
UterusCorpus11.3
WholeBlood12.35
Wholebrain8.3
colon13
pineal_day14.04
pineal_night14.46
retina14.075
small_intestine67.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1277_PI417557136
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.04 ± 1.26
Basal Forebrain1.53 ± 0.39
Basal Part of Pons0.83 ± 0.58
Cerebellar Cortex1.45 ± 0.91
Cerebellar Nuclei1.81 ± 0.8
Claustrum2.47 ± 0.95
Epithalamus1.69 ± 0.78
Frontal Lobe1.46 ± 0.8
Globus Pallidus2.31 ± 0.38
Hypothalamus1.86 ± 0.91
Insula1.46 ± 0.75
Limbic Lobe1.64 ± 0.74
Mesencephalon2.34 ± 1.11
Myelencephalon1.76 ± 0.84
Occipital Lobe1.84 ± 1.07
Parietal Lobe1.76 ± 0.95
Pontine Tegmentum1.78 ± 0.89
Striatum1.88 ± 0.55
Subthalamus1.62 ± 0.65
Temporal Lobe1.6 ± 0.97
Thalamus1.5 ± 0.69
White Matter2.06 ± 0.29
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
DdcCBCerebellum4.45
4.71
DdcCTXCerebral cortex2.92
2.26
DdcHIPHippocampal region3.43
2.36
DdcHPFHippocampal formation3.26
2.18
DdcHYHypothalamus14.29
12.5
DdcLSXLateral septal complex4.64
2.92
DdcMBMidbrain12.23
23.25
DdcMYMedulla8.28
10.27
DdcOLFOlfactory bulb13.18
7.15
DdcPPons9.48
13.24
DdcPALPallidum4.73
3.07
DdcRHPRetrohippocampal region3.09
1.99
DdcsAMYStriatum-like amygdalar nuclei3.64
2.31
DdcSTRStriatum3.77
2.2
DdcSTRdStriatum dorsal region3.04
1.87
DdcSTRvStriatum ventral region5.07
2.42
DdcTHThalamus4.4
3.07
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00748830 15 183 197 LVAYSSDQAHSSVER Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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