AutismKB 2.0

Annotation Detail for DDT


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Basic Information Top
Gene Symbol:DDT ( DDCT )
Gene Full Name: D-dopachrome tautomerase
Band: 22q11.23
Quick LinksEntrez ID:1652; OMIM: 602750; Uniprot ID:DOPD_HUMAN; ENSEMBL ID: ENSG00000099977; HGNC ID: 2732
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst2 / 6231932
fetus20 / 56401235
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult148 / 193912176
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor1 / 3436629
chondrosarcoma4 / 8282348
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor3 / 26384511
glioma9 / 10688384
head and neck tumor1 / 1363027
kidney tumor4 / 6895958
leukemia2 / 9584220
liver tumor10 / 96359103
lung tumor4 / 10312738
lymphoma2 / 7175527
non-neoplasia0 / 972500 
normal187 / 336030755
ovarian tumor5 / 7668265
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer8 / 10268077
retinoblastoma3 / 4635664
skin tumor5 / 12494940
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites3 / 4001574
bladder0 / 297570 
blood0 / 1234780 
bone5 / 7165569
bone marrow0 / 488010 
brain88 / 110098979
cervix1 / 4817120
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye10 / 21105447
heart7 / 8962678
intestine14 / 23447259
kidney14 / 21177766
larynx1 / 2414541
liver18 / 20774386
lung10 / 33697429
lymph2 / 4427045
lymph node7 / 9161076
mammary gland8 / 15327152
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary6 / 10205158
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta10 / 28082535
prostate15 / 18934579
salivary gland0 / 201550 
skin8 / 21057437
spleen1 / 5395218
stomach1 / 9661910
testis5 / 33044215
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus10 / 23287842
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202929_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts359.25
Adipocyte32.65
AdrenalCortex10.85
Adrenalgland11.9
Amygdala12.1
Appendix6.55
AtrioventricularNode6.35
BDCA4+_DentriticCells50.95
Bonemarrow10.65
BronchialEpithelialCells41.7
CD105+_Endothelial27.45
CD14+_Monocytes49.2
CD19+_BCells(neg._sel.)30.7
CD33+_Myeloid21.35
CD34+50.8
CD4+_Tcells31.8
CD56+_NKCells16.55
CD71+_EarlyErythroid127.15
CD8+_Tcells14.75
CardiacMyocytes20
Caudatenucleus9.7
Cerebellum5.55
CerebellumPeduncles11.5
CiliaryGanglion4.45
CingulateCortex11.5
Colorectaladenocarcinoma11.15
DorsalRootGanglion7.35
FetalThyroid10.5
Fetalbrain10.3
Fetalliver19.8
Fetallung9.55
GlobusPallidus8.05
Heart117.55
Hypothalamus14.5
Kidney19.6
Leukemia_chronicMyelogenousK-56210.3
Leukemia_promyelocytic-HL-6035.55
Leukemialymphoblastic(MOLT-4)9.3
Liver449.25
Lung52.3
Lymphnode9.2
Lymphoma_burkitts(Daudi)59.4
Lymphoma_burkitts(Raji)116.1
MedullaOblongata9.35
OccipitalLobe9.65
OlfactoryBulb8
Ovary7.4
Pancreas9.05
PancreaticIslet16.4
ParietalLobe10.9
Pituitary8.9
Placenta10.1
Pons10.15
PrefrontalCortex10.25
Prostate196.2
Salivarygland8.95
SkeletalMuscle9.2
Skin4.3
SmoothMuscle33.55
Spinalcord12.1
SubthalamicNucleus9.65
SuperiorCervicalGanglion7.35
TemporalLobe10.25
Testis9.8
TestisGermCell8.55
TestisIntersitial8.3
TestisLeydigCell7.4
TestisSeminiferousTubule8.05
Thalamus11.5
Thymus20.75
Thyroid53.4
Tongue9.05
Tonsil8.55
Trachea9
TrigeminalGanglion5.9
Uterus8.75
UterusCorpus4.25
WholeBlood12.25
Wholebrain36.45
colon28.6
pineal_day17.54
pineal_night13.22
retina13.375
small_intestine27.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P17769
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.9 ± 0.32
Basal Forebrain10.11 ± 0.15
Basal Part of Pons10.47 ± 0.4
Cerebellar Cortex10.07 ± 0.32
Cerebellar Nuclei10.58 ± 0.28
Claustrum9.8 ± 0.67
Epithalamus10.2 ± 0.27
Frontal Lobe10.33 ± 0.33
Globus Pallidus10.44 ± 0.52
Hypothalamus10.53 ± 0.23
Insula10.39 ± 0.31
Limbic Lobe9.8 ± 0.62
Mesencephalon10.15 ± 0.5
Myelencephalon10.08 ± 0.5
Occipital Lobe9.46 ± 0.56
Parietal Lobe10.14 ± 0.42
Pontine Tegmentum10.12 ± 0.37
Striatum9.62 ± 0.36
Subthalamus10.72 ± 0.15
Temporal Lobe10.28 ± 0.4
Thalamus10.09 ± 0.39
White Matter10.27 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
DdtCBCerebellum4.82
5.78
DdtCTXCerebral cortex3.63
2.33
DdtHIPHippocampal region1.71
2.01
DdtHPFHippocampal formation1.7
1.71
DdtHYHypothalamus1.54
0.9
DdtLSXLateral septal complex0.08
0.04
DdtMBMidbrain4.44
3.22
DdtMYMedulla24.92
18.73
DdtOLFOlfactory bulb3.56
3.34
DdtPPons18.94
12.98
DdtPALPallidum7.56
4.21
DdtRHPRetrohippocampal region1.7
1.25
DdtsAMYStriatum-like amygdalar nuclei0.47
0.27
DdtSTRStriatum0.85
0.66
DdtSTRdStriatum dorsal region0.72
0.6
DdtSTRvStriatum ventral region1.98
1.35
DdtTHThalamus1.56
1.22
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DOPD_HUMAN_0 0 0 0 FFPLESWQIGK PRIDE
DOPD_HUMAN_0 0 0 0 LCAAAASILGKPADR PRIDE
DOPD_HUMAN_0 0 0 0 SHSAHFFEFLTK PRIDE
DOPD_HUMAN_1 13 1 13 PFLELDTNLPANR PRIDE
DOPD_HUMAN_1 14 1 14 MPFLELDTNLPANR PRIDE
DOPD_HUMAN_1 21 1 21 PFLELDTNLPANRVPAGLEKR PRIDE
DOPD_HUMAN_100 11 100 110 FFPLESWQIGK PRIDE
DOPD_HUMAN_2 13 2 14 PFLELDTNLPANR PRIDE
DOPD_HUMAN_21 16 21 36 RLCAAAASILGKPADR PRIDE
DOPD_HUMAN_22 15 22 36 LCAAAASILGKPADR PRIDE
DOPD_HUMAN_6 8 6 13 DTNLPANR PRIDE
DOPD_HUMAN_75 12 75 86 SHSAHFFEFLTK PRIDE
DOPD_HUMAN_76 12 76 87 SHSAHFFEFLTK PRIDE
DOPD_HUMAN_99 11 99 109 FFPLESWQIGK PRIDE
PAp00004729 15 23 37 LCAAAASILGKPADR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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