AutismKB 2.0

Annotation Detail for DDX5


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Basic Information Top
Gene Symbol:DDX5 ( DKFZp434E109,DKFZp686J01190,G17P1,HLR1,HUMP68,p68 )
Gene Full Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
Band: 17q23.3
Quick LinksEntrez ID:1655; OMIM: 180630; Uniprot ID:DDX5_HUMAN; ENSEMBL ID: ENSG00000108654; HGNC ID: 2746
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body60 / 70761847
blastocyst88 / 623191412
fetus418 / 564012741
neonate34 / 310971093
infant16 / 23620677
juvenile94 / 555561691
adult1106 / 1939121570
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor18 / 127941406
bladder carcinoma9 / 17475515
breast (mammary gland) tumor47 / 94178499
cervical tumor15 / 34366436
chondrosarcoma42 / 82823507
colorectal tumor39 / 114246341
esophageal tumor32 / 172901850
gastrointestinal tumor80 / 119369670
germ cell tumor195 / 263845739
glioma41 / 106883383
head and neck tumor156 / 1363021144
kidney tumor48 / 68959696
leukemia61 / 95842636
liver tumor80 / 96359830
lung tumor19 / 103127184
lymphoma39 / 71755543
non-neoplasia80 / 97250822
normal3322 / 3360307988
ovarian tumor27 / 76682352
pancreatic tumor86 / 104616822
primitive neuroectodermal tumor of the CNS70 / 125680556
prostate cancer37 / 102680360
retinoblastoma29 / 46356625
skin tumor71 / 124949568
soft tissue/muscle tissue tumor50 / 125191399
uterine tumor99 / 902571096
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue9 / 13106686
adrenal gland65 / 331971958
ascites23 / 40015574
bladder23 / 29757772
blood141 / 1234781141
bone42 / 71655586
bone marrow51 / 488011045
brain1452 / 11009891318
cervix20 / 48171415
connective tissue119 / 149255797
ear15 / 16212925
embryonic tissue219 / 2157221015
esophagus33 / 202091632
eye103 / 211054488
heart58 / 89626647
intestine135 / 234472575
kidney146 / 211777689
larynx24 / 24145993
liver163 / 207743784
lung245 / 336974727
lymph9 / 44270203
lymph node43 / 91610469
mammary gland75 / 153271489
mouth130 / 670521938
muscle25 / 107715232
nerve17 / 157681078
ovary25 / 102051244
pancreas127 / 214812591
parathyroid8 / 20539389
pharynx39 / 41328943
pituitary gland33 / 165851989
placenta139 / 280825494
prostate106 / 189345559
salivary gland2 / 2015599
skin130 / 210574617
spleen159 / 539522947
stomach99 / 966191024
testis385 / 3304421165
thymus271 / 811313340
thyroid34 / 47473716
tonsil3 / 16999176
trachea281 / 524135361
umbilical cord7 / 13680511
uterus498 / 2328782138
vascular77 / 517801487
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200033_at
Cell line Expression level Expression bar
721_B_lymphoblasts2436.75
Adipocyte1248.1
AdrenalCortex1574.75
Adrenalgland462.85
Amygdala1345
Appendix536.55
AtrioventricularNode321.75
BDCA4+_DentriticCells4736.35
Bonemarrow391.6
BronchialEpithelialCells1671.15
CD105+_Endothelial2245.75
CD14+_Monocytes2694.45
CD19+_BCells(neg._sel.)3795
CD33+_Myeloid5568.6
CD34+3333.55
CD4+_Tcells5709.3
CD56+_NKCells5470.5
CD71+_EarlyErythroid1788.2
CD8+_Tcells5477.75
CardiacMyocytes848.6
Caudatenucleus748.2
Cerebellum325.35
CerebellumPeduncles547.3
CiliaryGanglion430.3
CingulateCortex596.5
Colorectaladenocarcinoma1702.7
DorsalRootGanglion349.65
FetalThyroid1200.8
Fetalbrain1195.2
Fetalliver720
Fetallung1338.9
GlobusPallidus340.95
Heart85.8
Hypothalamus1798.95
Kidney319.2
Leukemia_chronicMyelogenousK-562963.95
Leukemia_promyelocytic-HL-601051.15
Leukemialymphoblastic(MOLT-4)1940.7
Liver56.75
Lung646.55
Lymphnode2438.85
Lymphoma_burkitts(Daudi)1822.2
Lymphoma_burkitts(Raji)939.45
MedullaOblongata762.5
OccipitalLobe987.15
OlfactoryBulb1011.85
Ovary534.1
Pancreas834
PancreaticIslet1410.2
ParietalLobe697
Pituitary2506.3
Placenta746.95
Pons433.85
PrefrontalCortex1738.8
Prostate1606.6
Salivarygland1309.35
SkeletalMuscle126
Skin394.6
SmoothMuscle1477.8
Spinalcord1069.3
SubthalamicNucleus427.35
SuperiorCervicalGanglion198.2
TemporalLobe369.45
Testis642.5
TestisGermCell1927.7
TestisIntersitial1106.2
TestisLeydigCell1002.5
TestisSeminiferousTubule964.35
Thalamus826.2
Thymus1515.85
Thyroid2646.45
Tongue675.55
Tonsil1895.15
Trachea861.25
TrigeminalGanglion234.65
Uterus2095.9
UterusCorpus1079.5
WholeBlood2275.05
Wholebrain580.35
colon1209.95
pineal_day2549.36
pineal_night2536.06
retina1637.725
small_intestine1080
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_17025_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.93 ± 0.22
Basal Forebrain9.92 ± 0.16
Basal Part of Pons9.67 ± 0.18
Cerebellar Cortex9.91 ± 0.17
Cerebellar Nuclei9.76 ± 0.18
Claustrum10.1 ± 0.29
Epithalamus10.26 ± 0.37
Frontal Lobe9.69 ± 0.27
Globus Pallidus10.1 ± 0.25
Hypothalamus9.79 ± 0.12
Insula9.76 ± 0.15
Limbic Lobe9.89 ± 0.29
Mesencephalon9.82 ± 0.25
Myelencephalon9.84 ± 0.28
Occipital Lobe10.1 ± 0.29
Parietal Lobe9.79 ± 0.25
Pontine Tegmentum9.83 ± 0.28
Striatum10.12 ± 0.31
Subthalamus9.61 ± 0.27
Temporal Lobe9.79 ± 0.23
Thalamus9.79 ± 0.21
White Matter10.59 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ddx5CBCerebellum100
100
Ddx5CTXCerebral cortex100
100
Ddx5HIPHippocampal region100
100
Ddx5HPFHippocampal formation100
100
Ddx5HYHypothalamus98.21
92.57
Ddx5LSXLateral septal complex100
100
Ddx5MBMidbrain89.5
85.14
Ddx5MYMedulla89.94
90.12
Ddx5OLFOlfactory bulb100
100
Ddx5PPons89.54
90.08
Ddx5PALPallidum93.73
92.63
Ddx5RHPRetrohippocampal region100
100
Ddx5sAMYStriatum-like amygdalar nuclei100
100
Ddx5STRStriatum100
100
Ddx5STRdStriatum dorsal region100
100
Ddx5STRvStriatum ventral region100
100
Ddx5THThalamus96.91
96.75
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DDX5_HUMAN_242 11 242 252 TTYLVLDEADR PRIDE
DDX5_HUMAN_253 11 253 263 MLDMGFEPQIR PRIDE
DDX5_HUMAN_364 12 364 375 DGWPAMGIHGDK PRIDE
DDX5_HUMAN_452 10 452 461 QVSDLISVLR PRIDE
DDX5_HUMAN_69 9 69 77 TAQEVETYR PRIDE
DDX5_HUMAN_79 7 79 85 SKEITVR PRIDE
PAp00002120 15 178 192 ELAQQVQQVAAEYCR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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