AutismKB 2.0

Annotation Detail for DMXL1


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Basic Information Top
Gene Symbol:DMXL1 ( DKFZp779O1239,FLJ44772 )
Gene Full Name: Dmx-like 1
Band: 5q23.1
Quick LinksEntrez ID:1657; OMIM: 605671; Uniprot ID:DMXL1_HUMAN; ENSEMBL ID: ENSG00000172869; HGNC ID: 2937
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus17 / 56401230
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult73 / 193912137
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor2 / 2638457
glioma2 / 10688318
head and neck tumor7 / 13630251
kidney tumor1 / 6895914
leukemia4 / 9584241
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal97 / 336030728
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor2 / 12494916
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood4 / 12347832
bone6 / 7165583
bone marrow2 / 4880140
brain6 / 11009895
cervix1 / 4817120
connective tissue16 / 149255107
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus1 / 2020949
eye9 / 21105442
heart3 / 8962633
intestine5 / 23447221
kidney13 / 21177761
larynx1 / 2414541
liver1 / 2077434
lung5 / 33697414
lymph0 / 442700 
lymph node19 / 91610207
mammary gland3 / 15327119
mouth1 / 6705214
muscle9 / 10771583
nerve0 / 157680 
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta5 / 28082517
prostate7 / 18934536
salivary gland1 / 2015549
skin5 / 21057423
spleen1 / 5395218
stomach3 / 9661931
testis6 / 33044218
thymus1 / 8113112
thyroid5 / 47473105
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203791_at
Cell line Expression level Expression bar
721_B_lymphoblasts22.9
Adipocyte10.1
AdrenalCortex14.55
Adrenalgland8.7
Amygdala116.95
Appendix13.7
AtrioventricularNode13.25
BDCA4+_DentriticCells78.95
Bonemarrow11.45
BronchialEpithelialCells9.75
CD105+_Endothelial13.3
CD14+_Monocytes27.85
CD19+_BCells(neg._sel.)70.95
CD33+_Myeloid33.8
CD34+26.3
CD4+_Tcells16.5
CD56+_NKCells15.3
CD71+_EarlyErythroid11.2
CD8+_Tcells20.35
CardiacMyocytes18.85
Caudatenucleus34.65
Cerebellum8.2
CerebellumPeduncles14.4
CiliaryGanglion10.95
CingulateCortex15.3
Colorectaladenocarcinoma9.5
DorsalRootGanglion10.7
FetalThyroid17.45
Fetalbrain19.3
Fetalliver11.75
Fetallung10.65
GlobusPallidus8.55
Heart17.65
Hypothalamus56.9
Kidney9.6
Leukemia_chronicMyelogenousK-56218.4
Leukemia_promyelocytic-HL-609.85
Leukemialymphoblastic(MOLT-4)7.85
Liver17.2
Lung10.75
Lymphnode43.65
Lymphoma_burkitts(Daudi)25.65
Lymphoma_burkitts(Raji)30.15
MedullaOblongata16.85
OccipitalLobe16.4
OlfactoryBulb21.3
Ovary7.85
Pancreas10.1
PancreaticIslet11.05
ParietalLobe14.5
Pituitary13.5
Placenta8.25
Pons11.65
PrefrontalCortex122.2
Prostate189.7
Salivarygland9.85
SkeletalMuscle17.6
Skin10.95
SmoothMuscle18.85
Spinalcord58.2
SubthalamicNucleus11
SuperiorCervicalGanglion19.2
TemporalLobe9.9
Testis8.1
TestisGermCell15.3
TestisIntersitial8.85
TestisLeydigCell11.6
TestisSeminiferousTubule8.8
Thalamus18.1
Thymus8
Thyroid137.4
Tongue13.25
Tonsil12.55
Trachea9
TrigeminalGanglion14.8
Uterus64.2
UterusCorpus13.15
WholeBlood13.95
Wholebrain13.7
colon19
pineal_day121.46
pineal_night143.44
retina31.725
small_intestine9.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P101128
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.71 ± 0.68
Basal Forebrain4.27 ± 0.53
Basal Part of Pons4.58 ± 0.3
Cerebellar Cortex4.52 ± 0.39
Cerebellar Nuclei4.79 ± 0.36
Claustrum4.86 ± 0.66
Epithalamus4.17 ± 0.37
Frontal Lobe4.4 ± 0.43
Globus Pallidus4.6 ± 0.56
Hypothalamus4.23 ± 0.46
Insula4.3 ± 0.62
Limbic Lobe4.48 ± 0.46
Mesencephalon4.59 ± 0.41
Myelencephalon4.35 ± 0.47
Occipital Lobe4.74 ± 0.32
Parietal Lobe4.47 ± 0.47
Pontine Tegmentum4.38 ± 0.51
Striatum4.18 ± 0.38
Subthalamus4.91 ± 0.13
Temporal Lobe4.32 ± 0.49
Thalamus4.42 ± 0.43
White Matter5.47 ± 0.32
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dmxl1CBCerebellum15.83
16.39
Dmxl1CTXCerebral cortex9.48
6.99
Dmxl1HIPHippocampal region13.86
13.58
Dmxl1HPFHippocampal formation11.57
10.24
Dmxl1HYHypothalamus1.28
1.05
Dmxl1LSXLateral septal complex3
2.25
Dmxl1MBMidbrain4.27
3.93
Dmxl1MYMedulla14.33
13.7
Dmxl1OLFOlfactory bulb13.41
8.99
Dmxl1PPons6.62
6.79
Dmxl1PALPallidum1.94
1.41
Dmxl1RHPRetrohippocampal region6.93
4.95
Dmxl1sAMYStriatum-like amygdalar nuclei2.7
1.68
Dmxl1STRStriatum2.11
1.51
Dmxl1STRdStriatum dorsal region1.69
1.28
Dmxl1STRvStriatum ventral region2.8
1.74
Dmxl1THThalamus6.1
5
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DMXL1_HUMAN_2080 10 2080 2089 AEELQSAFGR PRIDE
PAp00499349 17 55 71 HGNIQVGCVDCSMQQGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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