AutismKB 2.0

Annotation Detail for DECR1


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Basic Information Top
Gene Symbol:DECR1 ( DECR,NADPH,SDR18C1 )
Gene Full Name: 2,4-dienoyl CoA reductase 1, mitochondrial
Band: 8q21.3
Quick LinksEntrez ID:1666; OMIM: 222745; Uniprot ID:DECR_HUMAN; ENSEMBL ID: ENSG00000104325; HGNC ID: 2753
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus39 / 56401269
neonate0 / 310970 
infant1 / 2362042
juvenile2 / 5555635
adult96 / 193912149
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma13 / 17475743
breast (mammary gland) tumor6 / 9417863
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor11 / 26384541
glioma3 / 10688328
head and neck tumor5 / 13630236
kidney tumor5 / 6895972
leukemia11 / 95842114
liver tumor3 / 9635931
lung tumor5 / 10312748
lymphoma2 / 7175527
non-neoplasia1 / 9725010
normal189 / 336030756
ovarian tumor4 / 7668252
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor8 / 12494964
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites1 / 4001524
bladder13 / 29757436
blood4 / 12347832
bone5 / 7165569
bone marrow11 / 48801225
brain22 / 110098919
cervix0 / 481710 
connective tissue1 / 1492556
ear6 / 16212370
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye6 / 21105428
heart17 / 89626189
intestine8 / 23447234
kidney22 / 211777103
larynx2 / 2414582
liver17 / 20774381
lung16 / 33697447
lymph0 / 442700 
lymph node6 / 9161065
mammary gland8 / 15327152
mouth1 / 6705214
muscle7 / 10771564
nerve1 / 1576863
ovary5 / 10205148
pancreas14 / 21481265
parathyroid3 / 20539146
pharynx8 / 41328193
pituitary gland3 / 16585180
placenta1 / 2808253
prostate4 / 18934521
salivary gland5 / 20155248
skin12 / 21057456
spleen2 / 5395237
stomach8 / 9661982
testis29 / 33044287
thymus1 / 8113112
thyroid4 / 4747384
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus15 / 23287864
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202447_at
Cell line Expression level Expression bar
721_B_lymphoblasts186.45
Adipocyte483.9
AdrenalCortex59.55
Adrenalgland110.2
Amygdala29
Appendix15.7
AtrioventricularNode12.45
BDCA4+_DentriticCells132.25
Bonemarrow29.3
BronchialEpithelialCells112.85
CD105+_Endothelial182
CD14+_Monocytes175.15
CD19+_BCells(neg._sel.)96.6
CD33+_Myeloid192.35
CD34+188.75
CD4+_Tcells92.15
CD56+_NKCells155.2
CD71+_EarlyErythroid105.55
CD8+_Tcells113.7
CardiacMyocytes57.9
Caudatenucleus28.95
Cerebellum10.1
CerebellumPeduncles18.85
CiliaryGanglion12.8
CingulateCortex25
Colorectaladenocarcinoma10
DorsalRootGanglion18.7
FetalThyroid54.5
Fetalbrain18.7
Fetalliver96.45
Fetallung73.9
GlobusPallidus13.2
Heart82.25
Hypothalamus54.9
Kidney110.25
Leukemia_chronicMyelogenousK-562119.25
Leukemia_promyelocytic-HL-6015.45
Leukemialymphoblastic(MOLT-4)73.45
Liver181.3
Lung47.55
Lymphnode43.25
Lymphoma_burkitts(Daudi)29.2
Lymphoma_burkitts(Raji)28.7
MedullaOblongata21.6
OccipitalLobe23.1
OlfactoryBulb27.8
Ovary12.1
Pancreas34.9
PancreaticIslet60.55
ParietalLobe19.75
Pituitary42.75
Placenta20.4
Pons18.15
PrefrontalCortex47.5
Prostate29.95
Salivarygland56.45
SkeletalMuscle25.25
Skin22.3
SmoothMuscle172.9
Spinalcord31.15
SubthalamicNucleus21.8
SuperiorCervicalGanglion14.85
TemporalLobe14.25
Testis113.2
TestisGermCell185.45
TestisIntersitial125.1
TestisLeydigCell51.15
TestisSeminiferousTubule58.4
Thalamus31
Thymus34.05
Thyroid52.95
Tongue45.65
Tonsil33.85
Trachea29.9
TrigeminalGanglion13.85
Uterus24.25
UterusCorpus19.05
WholeBlood175.55
Wholebrain25.4
colon157.4
pineal_day28.58
pineal_night29.64
retina41.325
small_intestine155.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P269619
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.25 ± 0.22
Basal Forebrain7.33 ± 0.11
Basal Part of Pons6.83 ± 0.26
Cerebellar Cortex6.98 ± 0.19
Cerebellar Nuclei7.35 ± 0.26
Claustrum6.66 ± 0.44
Epithalamus7.47 ± 0.24
Frontal Lobe7.22 ± 0.35
Globus Pallidus8.19 ± 0.19
Hypothalamus7.31 ± 0.36
Insula7.16 ± 0.2
Limbic Lobe7.12 ± 0.33
Mesencephalon7.36 ± 0.32
Myelencephalon7.25 ± 0.4
Occipital Lobe7.41 ± 0.27
Parietal Lobe7.39 ± 0.3
Pontine Tegmentum7.4 ± 0.42
Striatum7.84 ± 0.43
Subthalamus7.15 ± 0.19
Temporal Lobe7.18 ± 0.29
Thalamus7.59 ± 0.29
White Matter7.61 ± 0.25
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Decr1CBCerebellum5.35
7.63
Decr1CTXCerebral cortex1.07
1.39
Decr1HIPHippocampal region3.76
5.21
Decr1HPFHippocampal formation2.4
3.16
Decr1HYHypothalamus1.07
1.01
Decr1LSXLateral septal complex2.27
2.19
Decr1MBMidbrain1.47
2.59
Decr1MYMedulla6.87
9.18
Decr1OLFOlfactory bulb6.62
6.72
Decr1PPons1.25
1.9
Decr1PALPallidum0.18
0.19
Decr1RHPRetrohippocampal region0.86
1.15
Decr1sAMYStriatum-like amygdalar nuclei1.02
1.3
Decr1STRStriatum0.85
0.91
Decr1STRdStriatum dorsal region0.77
0.87
Decr1STRvStriatum ventral region0.48
0.44
Decr1THThalamus1.28
1.66
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DECR_HUMAN_0 0 0 0 VAFITGGGTGLGK PRIDE
DECR_HUMAN_111 23 111 133 VHAIQCDVRDPDMVQNTVSELIK PRIDE
DECR_HUMAN_133 22 133 154 VAGHPNIVINNAAGNFISPTER PRIDE
DECR_HUMAN_134 22 134 155 VAGHPNIVINNAAGNFISPTER PRIDE
DECR_HUMAN_156 7 156 162 LSPNAWK PRIDE
DECR_HUMAN_189 26 189 214 GAAFLSITTIYAETGSGFVVPSASAK PRIDE
DECR_HUMAN_215 16 215 230 AGVEAMSKSLAAEWGK PRIDE
DECR_HUMAN_223 8 223 230 SLAAEWGK PRIDE
DECR_HUMAN_234 10 234 243 FNVIQPGPIK PRIDE
DECR_HUMAN_235 10 235 244 FNVIQPGPIK PRIDE
DECR_HUMAN_252 14 252 265 LDPTGTFEKEMIGR PRIDE
DECR_HUMAN_252 9 252 260 LDPTGTFEK PRIDE
DECR_HUMAN_299 18 299 316 FDGGEEVLISGEFNDLRK PRIDE
DECR_HUMAN_317 14 317 330 VTKEQWDTIEELIR PRIDE
DECR_HUMAN_319 11 319 329 EQWDTIEELIR PRIDE
DECR_HUMAN_320 11 320 330 EQWDTIEELIR PRIDE
DECR_HUMAN_43 7 43 49 FFSPLQK PRIDE
DECR_HUMAN_50 11 50 60 AMLPPNSFQGK PRIDE
DECR_HUMAN_60 13 60 72 VAFITGGGTGLGK PRIDE
DECR_HUMAN_61 13 61 73 VAFITGGGTGLGK PRIDE
DECR_HUMAN_73 18 73 90 GMTTLLSSLGAQCVIASR PRIDE
DECR_HUMAN_74 18 74 91 GMTTLLSSLGAQCVIASR PRIDE
DECR_HUMAN_98 13 98 110 ATAEQISSQTGNK PRIDE
PAp00003002 18 74 91 GMTTLLSSLGAQCVIASR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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