Annotation Detail for DEFB1
Basic Information Top
| Gene Symbol: | DEFB1 ( BD1,DEFB-1,DEFB101,HBD1,MGC51822 ) |
|---|---|
| Gene Full Name: | defensin, beta 1 |
| Band: | 8p23.1 |
| Quick Links | Entrez ID:1672; OMIM: 602056; Uniprot ID:DEFB1_HUMAN; ENSEMBL ID: ENSG00000164825; HGNC ID: 2766 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.32949
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 2 / 564012 | 3 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 18 / 1939121 | 9 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 0 / 82823 | 0 | |
| colorectal tumor | 0 / 114246 | 0 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 0 / 119369 | 0 | |
| germ cell tumor | 0 / 263845 | 0 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 1 / 136302 | 7 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 0 / 95842 | 0 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 0 / 97250 | 0 | |
| normal | 10 / 3360307 | 2 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 6 / 125191 | 47 |  |
| uterine tumor | 0 / 90257 | 0 |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 0 / 123478 | 0 | |
| bone | 0 / 71655 | 0 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 2 / 1100989 | 1 |  |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 6 / 149255 | 40 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 0 / 215722 | 0 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 0 / 211054 | 0 | |
| heart | 0 / 89626 | 0 | |
| intestine | 2 / 234472 | 8 | |
| kidney | 20 / 211777 | 94 |  |
| larynx | 0 / 24145 | 0 | |
| liver | 0 / 207743 | 0 | |
| lung | 0 / 336974 | 0 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 0 / 153271 | 0 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 1 / 107715 | 9 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 1 / 214812 | 4 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 0 / 280825 | 0 | |
| prostate | 1 / 189345 | 5 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 2 / 210574 | 9 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 0 / 96619 | 0 | |
| testis | 0 / 330442 | 0 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 1 / 47473 | 21 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 0 / 232878 | 0 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 210397_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 8.7 | |
| Adipocyte | 7.45 | |
| AdrenalCortex | 10.35 | |
| Adrenalgland | 9 | |
| Amygdala | 7.5 | |
| Appendix | 8.4 | |
| AtrioventricularNode | 7 | |
| BDCA4+_DentriticCells | 8.25 | |
| Bonemarrow | 8.6 | |
| BronchialEpithelialCells | 7.65 | |
| CD105+_Endothelial | 9.3 | |
| CD14+_Monocytes | 9.3 | |
| CD19+_BCells(neg._sel.) | 8.15 | |
| CD33+_Myeloid | 14.8 | |
| CD34+ | 9.95 | |
| CD4+_Tcells | 8.45 | |
| CD56+_NKCells | 8.95 | |
| CD71+_EarlyErythroid | 7.35 | |
| CD8+_Tcells | 8 | |
| CardiacMyocytes | 16.75 | |
| Caudatenucleus | 6.7 | |
| Cerebellum | 6.25 | |
| CerebellumPeduncles | 9.2 | |
| CiliaryGanglion | 11.8 | |
| CingulateCortex | 7.95 | |
| Colorectaladenocarcinoma | 7.5 | |
| DorsalRootGanglion | 9.4 | |
| FetalThyroid | 7.55 | |
| Fetalbrain | 6.75 | |
| Fetalliver | 6.75 | |
| Fetallung | 5.65 | |
| GlobusPallidus | 6.05 | |
| Heart | 14.1 | |
| Hypothalamus | 8.45 | |
| Kidney | 2207.3 |  |
| Leukemia_chronicMyelogenousK-562 | 7.05 | |
| Leukemia_promyelocytic-HL-60 | 6.85 | |
| Leukemialymphoblastic(MOLT-4) | 5.55 | |
| Liver | 293.15 |  |
| Lung | 8.8 | |
| Lymphnode | 6.2 | |
| Lymphoma_burkitts(Daudi) | 9.6 | |
| Lymphoma_burkitts(Raji) | 11.65 | |
| MedullaOblongata | 6.4 | |
| OccipitalLobe | 6.75 | |
| OlfactoryBulb | 5.85 | |
| Ovary | 5.8 | |
| Pancreas | 675.1 | |
| PancreaticIslet | 1976.1 | |
| ParietalLobe | 8.25 | |
| Pituitary | 8.8 | |
| Placenta | 8 | |
| Pons | 7.4 | |
| PrefrontalCortex | 9 | |
| Prostate | 9.2 | |
| Salivarygland | 2675.8 | |
| SkeletalMuscle | 9.95 | |
| Skin | 75.35 | |
| SmoothMuscle | 8.15 | |
| Spinalcord | 8.1 | |
| SubthalamicNucleus | 8.25 | |
| SuperiorCervicalGanglion | 19 | |
| TemporalLobe | 7.5 | |
| Testis | 6.15 | |
| TestisGermCell | 6.25 | |
| TestisIntersitial | 6.25 | |
| TestisLeydigCell | 7.45 | |
| TestisSeminiferousTubule | 6.35 | |
| Thalamus | 9.1 | |
| Thymus | 5.8 | |
| Thyroid | 9 | |
| Tongue | 219.95 | |
| Tonsil | 8.15 | |
| Trachea | 59.7 | |
| TrigeminalGanglion | 8.65 | |
| Uterus | 10.85 | |
| UterusCorpus | 7.55 | |
| WholeBlood | 7.75 | |
| Wholebrain | 5.85 | |
| colon | 7.9 | |
| pineal_day | 10.68 | |
| pineal_night | 9.62 | |
| retina | 9.4 | |
| small_intestine | 7.55 | |
- Probe name: CUST_16860_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 1.66 ± 1 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 1.32 ± 0.32 | |
| Basal Part of Pons | 1.33 ± 0.52 | |
| Cerebellar Cortex | 3.09 ± 0.53 | |
| Cerebellar Nuclei | 3.21 ± 0.84 | |
| Claustrum | 2.55 ± 1.24 | |
| Epithalamus | 1.14 ± 0.95 | |
| Frontal Lobe | 1.67 ± 1.16 | |
| Globus Pallidus | 1.55 ± 0.88 | |
| Hypothalamus | 1.22 ± 0.82 | |
| Insula | 1.78 ± 0.89 | |
| Limbic Lobe | 1.45 ± 0.76 | |
| Mesencephalon | 1.84 ± 0.82 | |
| Myelencephalon | 1.89 ± 1 | |
| Occipital Lobe | 2.07 ± 0.91 | |
| Parietal Lobe | 1.8 ± 1.04 | |
| Pontine Tegmentum | 1.88 ± 0.9 | |
| Striatum | 1.51 ± 1.02 | |
| Subthalamus | 1.29 ± 0.52 | |
| Temporal Lobe | 1.69 ± 1.02 | |
| Thalamus | 3.44 ± 1.29 | |
| White Matter | 2 ± 0.58 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Defb1 | CB | Cerebellum | 3.1 | |
| 5.02 | | |||
| Defb1 | CTX | Cerebral cortex | 1.34 | |
| 1.61 | | |||
| Defb1 | HIP | Hippocampal region | 1 | |
| 1.26 | | |||
| Defb1 | HPF | Hippocampal formation | 1.8 | |
| 1.68 | | |||
| Defb1 | HY | Hypothalamus | 1.42 | |
| 1.62 | | |||
| Defb1 | LSX | Lateral septal complex | 1.6 | |
| 1.96 | | |||
| Defb1 | MB | Midbrain | 2.04 | |
| 2.53 | | |||
| Defb1 | MY | Medulla | 1.97 | |
| 3.06 | | |||
| Defb1 | OLF | Olfactory bulb | 1.76 | |
| 1.69 | | |||
| Defb1 | P | Pons | 1.7 | |
| 2.09 | | |||
| Defb1 | PAL | Pallidum | 0.54 | |
| 0.58 | | |||
| Defb1 | RHP | Retrohippocampal region | 3.36 | |
| 2.43 | | |||
| Defb1 | sAMY | Striatum-like amygdalar nuclei | 0.34 | |
| 0.27 | | |||
| Defb1 | STR | Striatum | 0.87 | |
| 1.1 | | |||
| Defb1 | STRd | Striatum dorsal region | 0.95 | |
| 1.28 | | |||
| Defb1 | STRv | Striatum ventral region | 0.87 | |
| 0.98 | | |||
| Defb1 | TH | Thalamus | 3.87 | |
| 4.08 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00796956 | 23 | 32 | 54 | SDHYNCVSSGGQCLYSACPIFTK | Peptide Atlas |