AutismKB 2.0

Annotation Detail for DHFR


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Basic Information Top
Gene Symbol:DHFR ( DHFRP1,DYR )
Gene Full Name: dihydrofolate reductase
Band: 5q14.1
Quick LinksEntrez ID:1719; OMIM: 126060; Uniprot ID:DYR_HUMAN; ENSEMBL ID: ENSG00000228716; HGNC ID: 2861
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst8 / 62319128
fetus18 / 56401231
neonate6 / 31097192
infant3 / 23620127
juvenile10 / 55556179
adult43 / 193912122
embryoid body4 / 7076156
blastocyst10 / 62319160
fetus42 / 56401274
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult56 / 193912128
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor3 / 3436687
chondrosarcoma5 / 8282360
colorectal tumor5 / 11424643
esophageal tumor2 / 17290115
gastrointestinal tumor6 / 11936950
germ cell tumor15 / 26384556
glioma2 / 10688318
head and neck tumor6 / 13630244
kidney tumor1 / 6895914
leukemia9 / 9584293
liver tumor10 / 96359103
lung tumor1 / 1031279
lymphoma6 / 7175583
non-neoplasia0 / 972500 
normal95 / 336030728
ovarian tumor3 / 7668239
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS23 / 125680183
prostate cancer4 / 10268038
retinoblastoma12 / 46356258
skin tumor2 / 12494916
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor3 / 9025733
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor7 / 9417874
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor8 / 11424670
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor13 / 26384549
glioma21 / 106883196
head and neck tumor5 / 13630236
kidney tumor5 / 6895972
leukemia2 / 9584220
liver tumor3 / 9635931
lung tumor3 / 10312729
lymphoma3 / 7175541
non-neoplasia0 / 972500 
normal138 / 336030741
ovarian tumor5 / 7668265
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer2 / 10268019
retinoblastoma5 / 46356107
skin tumor2 / 12494916
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder0 / 297570 
blood6 / 12347848
bone5 / 7165569
bone marrow5 / 48801102
brain27 / 110098924
cervix3 / 4817162
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue10 / 21572246
esophagus2 / 2020998
eye14 / 21105466
heart1 / 8962611
intestine11 / 23447246
kidney11 / 21177751
larynx0 / 241450 
liver10 / 20774348
lung3 / 3369748
lymph6 / 44270135
lymph node10 / 91610109
mammary gland2 / 15327113
mouth6 / 6705289
muscle2 / 10771518
nerve0 / 157680 
ovary4 / 10205139
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta7 / 28082524
prostate4 / 18934521
salivary gland3 / 20155148
skin12 / 21057456
spleen1 / 5395218
stomach2 / 9661920
testis24 / 33044272
thymus11 / 81131135
thyroid0 / 474730 
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus7 / 23287830
vascular1 / 5178019
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder4 / 29757134
blood2 / 12347816
bone6 / 7165583
bone marrow1 / 4880120
brain36 / 110098932
cervix1 / 4817120
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue22 / 215722101
esophagus1 / 2020949
eye10 / 21105447
heart7 / 8962678
intestine14 / 23447259
kidney10 / 21177747
larynx1 / 2414541
liver6 / 20774328
lung16 / 33697447
lymph2 / 4427045
lymph node16 / 91610174
mammary gland10 / 15327165
mouth0 / 670520 
muscle5 / 10771546
nerve1 / 1576863
ovary5 / 10205148
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta9 / 28082532
prostate3 / 18934515
salivary gland2 / 2015599
skin3 / 21057414
spleen0 / 539520 
stomach1 / 9661910
testis19 / 33044257
thymus2 / 8113124
thyroid4 / 4747384
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202532_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts259.3
Adipocyte43.75
AdrenalCortex78.25
Adrenalgland39.75
Amygdala30.2
Appendix108.3
AtrioventricularNode87.05
BDCA4+_DentriticCells24.4
Bonemarrow61.6
BronchialEpithelialCells32.8
CD105+_Endothelial315.1
CD14+_Monocytes42.95
CD19+_BCells(neg._sel.)43.55
CD33+_Myeloid46.55
CD34+236.45
CD4+_Tcells43.9
CD56+_NKCells43.35
CD71+_EarlyErythroid270.7
CD8+_Tcells41.65
CardiacMyocytes104.65
Caudatenucleus34.6
Cerebellum36.6
CerebellumPeduncles98.4
CiliaryGanglion80.3
CingulateCortex51.35
Colorectaladenocarcinoma93.85
DorsalRootGanglion59.35
FetalThyroid61
Fetalbrain35.35
Fetalliver105.2
Fetallung18.7
GlobusPallidus45.4
Heart89.95
Hypothalamus50
Kidney44.95
Leukemia_chronicMyelogenousK-56260.55
Leukemia_promyelocytic-HL-6062.35
Leukemialymphoblastic(MOLT-4)94.05
Liver81.55
Lung27.6
Lymphnode26.25
Lymphoma_burkitts(Daudi)123.7
Lymphoma_burkitts(Raji)72.3
MedullaOblongata57.75
OccipitalLobe39.5
OlfactoryBulb38.65
Ovary39.1
Pancreas43
PancreaticIslet43.4
ParietalLobe54.6
Pituitary47.8
Placenta31.35
Pons93.9
PrefrontalCortex50.55
Prostate34.3
Salivarygland52.15
SkeletalMuscle95.3
Skin62.45
SmoothMuscle50.25
Spinalcord43.15
SubthalamicNucleus47.6
SuperiorCervicalGanglion111.65
TemporalLobe48.65
Testis29.35
TestisGermCell37.35
TestisIntersitial48.45
TestisLeydigCell65.65
TestisSeminiferousTubule47
Thalamus54.05
Thymus28.7
Thyroid37.6
Tongue67.75
Tonsil57.1
Trachea31.65
TrigeminalGanglion101.9
Uterus22.35
UterusCorpus102.65
WholeBlood31.05
Wholebrain21.2
colon92.25
pineal_day46.44
pineal_night52.4
retina55.025
small_intestine112.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P320284
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.87 ± 0.6
Basal Forebrain6.26 ± 0.23
Basal Part of Pons6 ± 0.3
Cerebellar Cortex5.77 ± 0.24
Cerebellar Nuclei6.54 ± 0.26
Claustrum6.21 ± 0.59
Epithalamus6.19 ± 0.32
Frontal Lobe6.02 ± 0.36
Globus Pallidus6.77 ± 0.15
Hypothalamus6.26 ± 0.31
Insula5.79 ± 0.24
Limbic Lobe5.9 ± 0.33
Mesencephalon6.11 ± 0.32
Myelencephalon6.03 ± 0.37
Occipital Lobe5.98 ± 0.38
Parietal Lobe6.08 ± 0.33
Pontine Tegmentum6.06 ± 0.31
Striatum6.11 ± 0.4
Subthalamus6.24 ± 0.24
Temporal Lobe5.89 ± 0.31
Thalamus6.1 ± 0.25
White Matter6.82 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
DhfrCBCerebellum0.07
0.23
DhfrCTXCerebral cortex1.31
1.12
DhfrHIPHippocampal region8.67
10.57
DhfrHPFHippocampal formation6.63
7.38
DhfrHYHypothalamus4.26
4.35
DhfrLSXLateral septal complex1.74
1.49
DhfrMBMidbrain0.2
0.68
DhfrMYMedulla0.04
0.07
DhfrOLFOlfactory bulb6.11
5.52
DhfrPPons0.56
1.12
DhfrPALPallidum2.06
2.2
DhfrRHPRetrohippocampal region1.77
1.58
DhfrsAMYStriatum-like amygdalar nuclei3.54
2.67
DhfrSTRStriatum2.39
1.92
DhfrSTRdStriatum dorsal region1.04
0.75
DhfrSTRvStriatum ventral region7.31
5.91
DhfrTHThalamus2.5
2.44
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00070704 18 139 156 IMQDFESDTFFPEIDLEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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